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Opinion: The next frontier in biomedicine: AI models of the human immune system

STAT

If the Covid-19 pandemic has shown us one thing, it is how little we really know about how the human immune system works. Decoding and harnessing the power of the human immune system is one of the great frontiers of biomedicine.

Immunity 344
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Could long Covid’s signs of immune dysregulation in the blood lead to a diagnostic test?

STAT

New research published Thursday in Science has identified proteins present in the blood of people with long Covid that could point the way to a much-needed diagnostic test and possibly to future therapeutic targets.

Immunity 363
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Pandemic-related immunity gap in kids explains surge of respiratory infections in children in China, says WHO

STAT

The evidence presented to the WHO team pointed to what’s sometimes called an immunity gap that was created by the pandemic. But a rapidly organized meeting Thursday between the World Health Organization and health officials in China assuaged much of that concern.

Immunity 364
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Temperature-stable tuberculosis vaccine induces immune response

European Pharmaceutical Review

Investigators assessed whether administering a temperature-stable vaccine containing both ID93 and GLA-SE in a single vial would be as effective at inducing an immune response as a regimen in which non-thermostable ID93 and liquid GLA-SE are held in two vials and combined prior to injection. However, Sagawa et al.

Immunity 103
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Chikungunya vaccine demonstrates 99 percent immune response

European Pharmaceutical Review

Instead, the study tested for an immune response at levels that are thought to protect against the disease if infected with the virus. The post Chikungunya vaccine demonstrates 99 percent immune response appeared first on European Pharmaceutical Review. Results from the Phase III clinical trial was published in The Lancet.

Immunity 105
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STAT+: Dreams of cancer vaccines are becoming more real. Here are 9 scientists making it happen 

STAT

But many other modes of immunotherapy for cancer were approved first — checkpoint blockade drugs like Keytruda and engineered immune cell therapies like Yescarta. Cancer vaccines may also be able to help train the immune system to recognize and kill cancers related to viruses like HPV.

Vaccines 362
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Tackling immune-mediated disease with CAR Tregs

European Pharmaceutical Review

Recognising the potential of CAR T cells to act as highly targeted therapeutics, several biotechnology companies – including Sangamo Therapeutics – have established development pipelines of CAR T regulatory cells (Tregs) that aim to tackle immune?mediated What are Tregs and how are they applicable to immune-mediated disease?

Immunity 140