STAT

DECEMBER 10, 2022

NEW ORLEANS — Researchers had hoped in recent years that a protein called GPRC5D might offer a new way to get the immune system to hunt down and destroy multiple myeloma cells. Now, the results of a Phase 2 study on a bispecific antibody targeting this protein offers confirmation.

Immunity 314

Immunity Immunization 314

European Pharmaceutical Review

OCTOBER 20, 2022

Recognising the potential of CAR T cells to act as highly targeted therapeutics, several biotechnology companies – including Sangamo Therapeutics – have established development pipelines of CAR T regulatory cells (Tregs) that aim to tackle immune?mediated What are Tregs and how are they applicable to immune-mediated disease?

Immunity 140

Immunity Immunization Drug Development 140

pharmaphorum

JULY 26, 2021

While there are plenty of tests already available that can give a yes/no reading of whether antibodies are present, the Chembio test measures the level of antibodies as well, so can tell whether a patient is likely to be protected against the coronavirus. The post Rapid COVID immune status test launched in UK, Ireland appeared first on.

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Immunity Immunization Vaccines 137

European Pharmaceutical Review

MARCH 6, 2023

Investigators assessed whether administering a temperature-stable vaccine containing both ID93 and GLA-SE in a single vial would be as effective at inducing an immune response as a regimen in which non-thermostable ID93 and liquid GLA-SE are held in two vials and combined prior to injection. However, Sagawa et al.

Immunity 103

Immunity Immunization Vaccines Communication 103

European Pharmaceutical Review

JUNE 13, 2023

Instead, the study tested for an immune response at levels that are thought to protect against the disease if infected with the virus. The post Chikungunya vaccine demonstrates 99 percent immune response appeared first on European Pharmaceutical Review. Results from the Phase III clinical trial was published in The Lancet.

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Immunity Immunization Vaccines 105

STAT

FEBRUARY 22, 2023

The data were presented Wednesday to the Advisory Committee on Immunization Policy, which advises the Centers for Disease Control and Prevention. Read the rest…

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Immunity Immunization Hospitals Vaccines 246

Express Pharma

JUNE 20, 2023

The vaccine efforts of the COVID-19 pandemic highlighted our knowledge about gaps in the immune system. Reductionist systems, such as genetically identical inbred mice, have long been the choice for immunology research, which focuses on studying the cells, tissues, and organs that make up the immune system.

Immunity 105

Immunity Immunization Vaccines Hospitals 105

pharmaphorum

NOVEMBER 4, 2021

While still preliminary, the experience with the two patients back up Talaris’ hope that giving a one-shot dose of FCR001 the day after an organ transplant could stimulate immune tolerance in the recipient, and avoid the side effects of current drug treatments such as infections, heart disease, and some forms of cancer.

Immunity 98

Immunity Immunization 98

World Pharma News

JANUARY 29, 2024

A new technology to increase visibility of cancer cells to the immune system using CRISPR has been developed, and could lead to a new way to treat cancer. Major histocompatibility complex (MHC) class I molecules are an immune complex present on the surface of all cells in humans.

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Immunity Immunization 77

STAT

OCTOBER 8, 2024

So join us as we hoist the ever-present cup of stimulation — our choice today is coconut rum — and attack the fast-growing to-do list. Lots of sunshine and clear blue skies are once again enveloping the Pharmalot campus, where the official mascots are bounding about the grounds in search of creatures to annoy. ” A U.S.

Compounding 247

Compounding Compounding Pharmacies Vaccines Immunity 247

European Pharmaceutical Review

AUGUST 25, 2022

This strategy has failed to gain a foothold in the past as the patient’s immune system interferes, destroying the unprotected oncolytic viruses. 7 Studies also sought to modify oncolytic viruses with additional genes that more efficiently recruit the patient’s immune system to target tumour cells. suppressing activity.

Immunity 111

Immunity Immunization Chemotherapy Packaging 111

ALiEM - Pharm Pearls

OCTOBER 11, 2024

A 76-year-old female presented with a lingering cough and an oral lesion to the left lower cheek. On the day of presentation, she developed a painful, intermittently bleeding “blood blister” to the left lower cheek that had increased in size, as well as new red spots on her arms and legs. Physical Exam Vitals : 98.3°F; Plt 6, WBC 10.3

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Immunity Immunization 152

Pharma Times

APRIL 17, 2023

Efti’s targeting activation of antigen-presenting cells delivers an adaptive immunity to fight cancer

Immunity 111

Immunity Immunization 111

World Pharma News

OCTOBER 9, 2023

NYSE: PFE) will present data across its infectious disease portfolio at the upcoming IDWeek 2023 held in Boston from October 11-15, 2023. Pfizer Inc. Data from 45 abstracts will highlight the advances Pfizer is making in helping prevent and treat certain infectious diseases, particularly respiratory illnesses.

Vaccines 88

Vaccines Immunity Immunization 88

ALiEM - Pharm Pearls

OCTOBER 25, 2024

A 64-year-old male with a history of bipolar 1 disorder, PTSD, anxiety, depression, obsessive-compulsive disorder, GERD, and HTN presented to the ED with the chief complaint of foreign body and self-injury. Numerous linear metallic foreign bodies are present throughout the right forearm; several new foreign bodies are noted.

Vaccines 177

Vaccines Immunity Immunization 177

ALiEM - Pharm Pearls

MARCH 29, 2023

If LP is traumatic or pleocytosis is present, administer antibiotics and admit. Example: A 48-day-old infant presents with a fever of 100.6F, CRP of 22 mg/L, and otherwise normal procalcitonin, ANC, and UA. This requires a documented positive viral swab and not just a presentation consistent with a viral syndrome.

Hospitals 360

Hospitals Documentation Inpatient Immunity 360

ALiEM - Pharm Pearls

OCTOBER 21, 2024

A 5-year-old generally healthy fully immunized boy presented to the ED with worsening left ear redness, swelling, and tenderness that his family noticed the day before presentation. His family had also recently noticed an abrasion over that ear.

Medical Schools 169

Medical Schools Immunity Immunization 169

Pharmacy Joe

OCTOBER 18, 2023

In this episode, I’ll discuss why hypokalemia can result from digoxin immune fab fragment administration. With the administration of antidote therapy with digoxin immune fab fragments, the function of the sodium-potassium ATPase pump is restored.

Immunity 52

Immunity Immunization Hospitals Inpatient 52

Pharmacy Joe

OCTOBER 18, 2023

In this episode, I’ll discuss why hypokalemia can result from digoxin immune fab fragment administration. With the administration of antidote therapy with digoxin immune fab fragments, the function of the sodium-potassium ATPase pump is restored.

Immunity 52

Immunity Immunization Hospitals Inpatient 52

ALiEM - Pharm Pearls

DECEMBER 18, 2023

A 19-year-old female with a past medical history of epilepsy presented to the emergency department for evaluation of rash and fever. Two days prior to presentation she began to experience fevers with a Tmax of 103°F. Diagnosis can be extremely challenging due to the variability in clinical presentation. Int J Mol Sci.

Immunity 177

Immunity Immunization 177

pharmaphorum

SEPTEMBER 10, 2020

The spray is based on the SporeVax technology developed at Sporegen by Royal Holloway University Professor Simon Cutting and takes the form of heat killed spores of a bacterium – Bacillus subtilis – that stimulate a part of the innate immune system known as mucosal immunity.

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Vaccines Adverse Reactions Immunity Immunization 133

European Pharmaceutical Review

DECEMBER 12, 2023

He discusses why NK cell therapy’s ability to generate ‘synthetic immunity’ in the body means this modality holds potential as an anti-cancer treatment. We specialise in the development of new cutting-edge immunotherapies , based on the use of therapeutic antibodies capable of activating the immune system to fight cancer.

Immunity 124

Immunity Immunization Chemotherapy Pharmaceutical Companies 124

Express Pharma

SEPTEMBER 26, 2023

Their research, conducted in collaboration with scientists from Dayanand Medical College and Hospital in Punjab and the CSIR-Institute for Himalayan Bioresource Technology in Himachal Pradesh, presents a novel, faster, and more effective approach to producing vaccines for challenging infectious diseases.

Vaccines 111

Vaccines Immunity Immunization Hospitals 111

Pharmaceutical Technology

SEPTEMBER 14, 2022

Before TIL infusion, the patient undergoes lymphodepletion, which reduces the proportion of myeloid immune suppressive cells and creates space for the incoming lymphocytes. The high level of neoantigens in melanoma makes this the ideal setting for TIL therapy, with tumours often containing multiple clones of tumour-reactive immune cells.

Immunity 98

Immunity Immunization 98

pharmaphorum

JULY 18, 2022

CanSinoBIO’s inhalant has finished phase three trials in China and is presently undergoing trials in several countries. It then elicits an immune response against that spike protein. When you have mucosal immunity, the immunoglobulins called IgAs start neutralising the virus at the point of entry. The inhalant version.

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Vaccines Health and Personal Care Stores Immunity Immunization 138

ALiEM - Pharm Pearls

DECEMBER 20, 2024

A 3-year-old male with a history of severe atopic dermatitis presented for facial rash and hand pain. On the day of presentation, he woke up with a new rash over his face and hands which prompted the ED visit. He is up to date on childhood immunizations and is not prescribed any oral medications.

Immunity 130

Immunity Immunization 130

European Pharmaceutical Review

SEPTEMBER 20, 2023

Results of a Phase I/II study has revealed that a booster dose of a novel, self-amplifying messenger RNA (sa-mRNA) COVID-19 vaccine induces a robust, broadly cross-reactive, and durable immune response in adults. All three vaccines induced robust neutralising immune response against the D614G variant at Day 29.

Vaccines 98

Vaccines Immunity Immunization 98

pharmaphorum

APRIL 12, 2021

The adenosine pathway has emerged as an attractive target for immuno-oncology R&D because it is thought to reduce the activity of misfunctioning regulatory T-cells that inhibit the immune response against cancers. Exscientia will lead the clinical development of the A2A drug, with Evotec retaining co-ownership rights.

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Immunity Immunization Compounding 127

European Pharmaceutical Review

MARCH 26, 2024

Moderna’s next-generation COVID-19 vaccine mRNA-1283 demonstrated a higher immune response against SARS-CoV-2, interim results from the company’s Phase III trial show. These findings were based on data comparing the treatment to mRNA-1273.222 (Spikevax ® ), Moderna’s licensed vaccine for the condition.

Vaccines 110

Vaccines Immunity Immunization 110

Express Pharma

JULY 12, 2024

In the context of modern medicine, messenger RNA (mRNA) serves as the hacker, carrying genetic instructions to produce specific proteins within cells that can induce desired immune responses or sequester maladaptive cellular elements.

Immunity 103

Immunity Immunization Compounding Vaccines 103

European Pharmaceutical Review

SEPTEMBER 1, 2023

Global mRNA-based oncology therapy market At present, the pharmaceutical industry is still awaiting the first regulatory approval of an mRNA-based oncology therapy. If successful, this trial will mark the first time an mRNA cancer vaccine and an immune checkpoint inhibitor have shown improved recurrence-free survival rates.

Immunity 110

Immunity Immunization Vaccines 110

Express Pharma

NOVEMBER 13, 2024

Bristol Myers Squibb and Cabaletta Bio are set to present promising Phase I data on CD19-directed CAR T therapies for severe, refractory lupus at the American College of Rheumatology 2024. Edits made by EP News Bureau The post CAR T cell therapies to promote drug-free remission in lupus care appeared first on Express Pharma.

Immunity 105

Immunity Immunization 105

Pharmaceutical Technology

SEPTEMBER 5, 2022

The needle-free vaccine can also elicit complete immune protection against the SARS-CoV-2 virus after just a single inhalation. According to studies, Convidecia Air could prompt robust cellular, humoral and mucosal immunity to attain triple protection as well as control the virus spread and the infection.

Vaccines 105

Vaccines Immunity Immunization 105

pharmaphorum

APRIL 9, 2021

Founded in 1999, Marseille-based company Innate Pharma is on a mission to develop immunotherapies that take advantage of the body’s innate immune system. The cytokine release prompts T-cells so they can translate that first innate immune response into a long-lasting adaptive immune response. About the interviewee.

Immunity 122

Immunity Immunization Packaging 122

Pharmaceutical Technology

MAY 26, 2023

was powered by the advent of immune-checkpoint inhibitors, added Chalk. Checkpoint modulators, cytokines and oncolytic viruses are also considered as part of the overall immune-oncology field. Apart from providing an overview of the current pipeline, the webinar also presented the findings from a GlobalData survey.

Immunity 105

Immunity Immunization Vaccines Compounding 105

European Pharmaceutical Review

SEPTEMBER 13, 2022

The current standard of care for patients with recurrent, unresectable or metastatic disease is immune checkpoint inhibitor monotherapy targeting anti-programmed death receptor 1 (anti-PD-1) and programmed death ligand 1 (PD-L1), but only about half of patients respond to this therapy.

Immunity 96

Immunity Immunization 96

Express Pharma

AUGUST 27, 2024

This method is time-efficient and expected to present all antigens, mimicking natural infection. Codon deoptimization involves reducing the frequency of underrepresented codon pairs without changing amino acid sequences, resulting in a highly efficient virus attenuation strategy.

Vaccines 104

Vaccines Immunity Immunization Communication 104