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ISMP Safety Brief: Prevent Additional Patient Harm and Deaths From Accidental Daily Methotrexate Dosing

National Association of Boards of Pharmacy

The labeled indications for methotrexate later expanded to include the treatment of non-oncologic conditions, including psoriasis and rheumatoid arthritis. The community pharmacy dispensed a three-month quantity of medication but provided instructions on the label to take 15 mg (six 2.5 mg tablets) once daily.