Researchers identify genetic changes responsible for rare childhood immune disorders
Pharma Times
MAY 30, 2024
Affecting the immune system, various forms of SCID are estimated to affect one in 75,000 to 100,000 newborns
Hospitals Immunity Immunization 
STAT+: Hospitals struggle to make money on CAR-T cancer therapies, but their fortunes may change
STAT
JULY 20, 2023
WASHINGTON — Hospitals for years have complained that Medicare pays so little for CAR-T cancer treatments that they sometimes lose money administering the incredibly expensive treatments. CAR-T uses the body’s own immune system to kill cancerous cells. Continue to STAT+ to read the full story…
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STAT+: Brigham creates institute focused on immunology with record $100 million gift
STAT
MAY 10, 2023
Brigham and Women’s Hospital will launch a new institute focused on immunology and inflammation, thanks to a $100 million gift, the largest in the hospital’s history. The institute will also investigate the aging of the immune system and immune dysfunction in cancer.
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STAT+: Galapagos, in makeover mode, strikes deal to make CAR-T therapies at blood centers across U.S.
STAT
MAY 15, 2024
Immune cells have to be removed from a patient, shipped to specialty sites, where they’re engineered with cancer-killing abilities, and then returned to the hospital for infusion back into patients. CAR-Ts have proven to be potent treatments for certain cancers, but they are complicated medicines to make.
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CDC advisers endorse RSV monoclonal antibody for infants, high-risk young children
STAT
AUGUST 3, 2023
A panel of advisers to the Centers for Disease Control and Prevention unanimously voted Thursday to recommend wide use among infants and some high-risk children of an antibody designed to protect against RSV , the country’s leading cause of infant hospitalization. Read the rest…
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Advancing research on human immune systems in India to develop better vaccines
Express Pharma
JUNE 20, 2023
The vaccine efforts of the COVID-19 pandemic highlighted our knowledge about gaps in the immune system. Reductionist systems, such as genetically identical inbred mice, have long been the choice for immunology research, which focuses on studying the cells, tissues, and organs that make up the immune system.
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STAT+: Pharma’s ambitious antibiotic venture fund makes another investment
STAT
JANUARY 5, 2023
million to BioVersys, which is developing an antibiotic to combat a type of bacteria that affects people with compromised immune systems and is increasingly responsible for infections in hospitalized patients. In its latest move, the fund is providing $7.5
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STAT+: Medicare would have saved $3.7 billion on Part B drugs if inflationary rebates were around in a recent three-year period
STAT
JANUARY 3, 2023
More specifically, 70 of the 93 top-selling drugs covered by the Medicare Part B program – which are typically pricier medicines that are administered by physicians or in hospitals – between 2018 and 2020 would have been subject to inflationary rebates each year, according to the analysis published in JAMA.
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Early data shows Russia’s Sputnik V COVID-19 vaccine produces immune response
pharmaphorum
SEPTEMBER 7, 2020
A trial of Russia’s Sputnik V coronavirus vaccine has shown the jab produces an immune response, although the study was too small to produce conclusive findings, particularly on safety. For our vaccine, we use two different adenovirus vectors in a bid to avoid the immune system becoming immune to the vector.”.
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How cancer evades immune system detection and spreads
World Pharma News
APRIL 11, 2023
A research team led by the National Cancer Centre Singapore (NCCS) with members from Duke-NUS Medical School, KK Women and Children’s Hospital, A*STAR's Singapore Immunology Network (SIgN), the University of Southampton and the Alan Turing Institute, has discovered how cancer evades the immune system and metastasises in the body, and explores how to (..)
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Immune cell helps predict skin cancer patients’ responses to immunotherapies
Pharma Times
JANUARY 5, 2024
Vd1-gd T cells were effective in predicting positive responses to ICI therapy
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How immune cells "sniff out" pathogens
World Pharma News
NOVEMBER 12, 2024
Immune cells are capable of detecting infections just like a sniffer dog, using special sensors known as Toll-like receptors, or TLRs for short. In a recent study, researchers from the University of Bonn and the University Hospital Bonn (UKB) used an innovative method to answer these questions.
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Cell therapy approach harnesses the immune system in a different way to stop cancer
World Pharma News
MARCH 19, 2024
A new cancer treatment that uses a person’s own immune cells has been approved by the U.S. James Cancer Hospital and Richard J. Food and Drug Administration (FDA) for treating the most dangerous type of skin cancer. Solove Research Institute (OSUCCC - James).
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NIH kicks off COVID-19 immune modulator trial
Outsourcing Pharma
OCTOBER 21, 2020
The US agency has launched a large clinical trial to examine the viability of using immune modulators to treat patients hospitalized with COVID-19.
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First successful CAR-T treatment for muscle inflammation
European Pharmaceutical Review
FEBRUARY 24, 2023
University Hospital Erlangen in Germany is the first in the world to use chimeric antigen receptor (CAR) T-cells to successfully treat a patient suffering from a severe case of muscle inflammation (myositis). The researchers modified the patients’ own immune cells.
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Hospital Universitario and Josep Carreras develop cell therapy for leukaemia
Pharmaceutical Technology
JANUARY 17, 2023
Spain’s Hospital Universitario 12 de Octubre researchers, along with the Josep Carreras Leukaemia Research Institute, have developed a new cell therapy based on STAb cells to treat a type of leukaemia. The post Hospital Universitario and Josep Carreras develop cell therapy for leukaemia appeared first on Pharmaceutical Technology.
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Episode 862: Why hypokalemia can result from digoxin immune fab fragment administration
Pharmacy Joe
OCTOBER 18, 2023
In this episode, I’ll discuss why hypokalemia can result from digoxin immune fab fragment administration. With the administration of antidote therapy with digoxin immune fab fragments, the function of the sodium-potassium ATPase pump is restored.
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Episode 862: Why hypokalemia can result from digoxin immune fab fragment administration
Pharmacy Joe
OCTOBER 18, 2023
In this episode, I’ll discuss why hypokalemia can result from digoxin immune fab fragment administration. With the administration of antidote therapy with digoxin immune fab fragments, the function of the sodium-potassium ATPase pump is restored.
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IIT Mandi researchers propose a protein-based vaccine against pork tapeworm
Express Pharma
SEPTEMBER 26, 2023
Their research, conducted in collaboration with scientists from Dayanand Medical College and Hospital in Punjab and the CSIR-Institute for Himalayan Bioresource Technology in Himachal Pradesh, presents a novel, faster, and more effective approach to producing vaccines for challenging infectious diseases.
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The Febrile Infant: Incorporating the 2021 American Academy of Pediatrics guidelines
ALiEM - Pharm Pearls
MARCH 29, 2023
The goal remains to identify infants with bacterial infections in this at-risk cohort of patients while also considering the balance of cost-effectiveness on a population scale and the potential for iatrogenic harm with evaluation such as unnecessary lumbar punctures, unnecessary antibiotics, and unnecessary hospitalization. No LP needed.
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Epigenetically acting drugs could support cancer immunotherapy
World Pharma News
OCTOBER 31, 2023
This leads to the formation of new mRNA transcripts and also new proteins, as scientists from the German Cancer Research Center and the University Hospital Tübingen have now published. These "therapy-induced epitopes" could help the immune system recognize cancer cells.
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New drug prevents flu-related inflammation and lung damage
World Pharma News
APRIL 10, 2024
Jude Children's Research Hospital, University of Houston, Tufts University School of Medicine and Fox Chase Cancer Center created a drug that can prevent flu-induced lung injury. In a mouse model, the drug achieves a novel balance between shutting down runaway inflammation and allowing the immune system to stop the virus.
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Episode 582: Why hypokalemia can result from digoxin immune fab fragment administration
Pharmacy Joe
FEBRUARY 10, 2021
In this episode, I’ll discuss why hypokalemia can result from digoxin immune fab fragment administration. With the administration of antidote therapy with digoxin immune fab fragments, the function of the sodium-potassium ATPase pump is restored.
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Clinicians report success with first test of drug in a patient with life-threatening blood clotting disorder
World Pharma News
MAY 20, 2024
A team led by investigators from Massachusetts General Hospital, a founding member of the Mass General Brigham healthcare system, used a new drug to save the life of a patient with immune thrombotic thrombocytopenic purpura (iTTP), a rare disorder characterized by uncontrolled clotting throughout the small blood vessels.
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Nano-immunotherapy developed to improve lung cancer treatment
World Pharma News
JUNE 17, 2024
Researchers at Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system, have developed a new nanomedicine therapy that delivers anticancer drugs to lung cancer cells and enhances the immune system's ability to fight cancer.
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Capturing transporter structure paves the way for drug development
World Pharma News
MAY 23, 2023
Jude Children’s Research Hospital and the University of Texas Southwestern Medical Center studied the structure and function of a transporter involved in cancer and immunity. Scientists at St. They captured six structures of the transporter, including when it was bound to an inhibitor, providing unprecedented insight into how it works.
Pharmacogenomics: The Up-and-Coming Field of Pharmacy
Pharmacy Is Right For Me
AUGUST 26, 2024
You may think of a clinical pharmacist working in a community pharmacy or a hospital pharmacist working in an in-patient unit. Pharmacogenomic researchers discovered a genetic variant in the immune system that causes this life-threatening allergic reaction to Abacavir. What is your first thought when you think of a career in pharmacy?
Re-engineering proteins to develop novel immunotherapies
European Pharmaceutical Review
JULY 13, 2023
The field of immunotherapy is constantly evolving with the ultimate goal to develop new treatments that help the body’s immune system fight cancer. Immune cells, such as T cells and natural killer (NK) cells, have the inherent ability to combat diseases, including cancer, but are often inhibited by the body’s own suppressive mechanisms.
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Coronavirus re-infection case confirmed in the US
pharmaphorum
OCTOBER 14, 2020
The latest case was recorded in the Lancet Infectious Diseases journal and involved a 25 year-old man with no known immune disorders or underlying conditions. Although the authors said further research was needed, they said the findings suggested previous exposure may not confer immunity and that people should comply with control measures.
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New treatment could reverse hair loss caused by an autoimmune skin disease
World Pharma News
MAY 9, 2024
Researchers at MIT, Brigham and Women's Hospital, and Harvard Medical School have developed a potential new treatment for alopecia areata, an autoimmune disorder that causes hair loss and affects people of all ages, including children. For most patients with this type of hair loss, there is no effective treatment.
ESMO: TIL therapy improves on Yervoy in melanoma trial
pharmaphorum
SEPTEMBER 11, 2022
With the results in hand, the developers of the therapy – from the Netherlands Cancer Institute and Norway’s National Center for Cancer Immune Therapy – say they now intend to file for regulatory approvals in Europe before the end of the year, without a commercial partner “to try to ensure that it remains affordable.”
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Preventative approach could reduce immunotherapy side effects
European Pharmaceutical Review
JANUARY 4, 2024
Immunotherapy drugs like teclistamab can result in potentially fatal side effects, including CRS and immune cell-associated neurotoxicity syndrome (ICANS). An overactive immune response [is] the hallmark of CRS,” Landgren added. The drug tocilizumab for example, has been used historically to treat CRS from immunotherapies.
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BCMA CAR T therapy facilitates potential autoimmune breakthrough
European Pharmaceutical Review
FEBRUARY 1, 2024
Positive results from the first global study for chimeric antigen receptor (CAR)-antologous T cell (BCMA CAR T) injection (Equecabtagene Autoleucel) in immune-mediated necrotising myopathy (IMNM), suggest that the cell therapy could provide a new therapeutic option for antibody-mediated autoimmune disorders.
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Unlocking the mystery of long-lasting cancer treatment
World Pharma News
JULY 6, 2023
New insights explaining why some children have a longer remission than others after having cutting-edge CAR T-cell therapy for leukaemia have been revealed by researchers at UCL, Great Ormond Street Hospital, and the Wellcome Sanger Institute.
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New study paves way for immunotherapies tailored for childhood cancers
World Pharma News
JANUARY 21, 2025
Researchers at Karolinska Institutet and the Astrid Lindgren Children's Hospital in Sweden have determined how children's immune systems react to different kinds of cancer depending on their age.
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Novartis hails digital strategy as profits hold up during pandemic
pharmaphorum
JANUARY 26, 2021
Novartis has said that its investment in digital technology has helped it to ride out the worst of the pandemic, although sales of some of its newly-launched products have been affected by a fall in prescriptions and hospital visits. billion and profits growing 2% to just over $3 billion.
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F.D.A. Aims to Give Final Approval to Pfizer Vaccine by Early Next Month
NY Times
AUGUST 3, 2021
The Food and Drug Administration’s move is expected to kick off more vaccination mandates for hospital workers, college students and federal troops.
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145 New tool to boost cancer immunotherapy effects
World Pharma News
MARCH 25, 2025
Among other functions, the NK cells (Natural Killers, a type of lymphocyte forming part of the immune system) have the capacity to detect and eliminate cancer cells. But in some cases they cannot overcome the tumours defense mechanism and the cancer grows.
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NICE recommends injectable bispecific antibody for aggressive blood cancer
European Pharmaceutical Review
FEBRUARY 1, 2024
Epcoritamab is designed to simultaneously attach to two different cells, one immune T cell and one cancerous lymphoma cell, bringing them together. In this way, the immune T cell is activated to eliminate the cancerous lymphoma cell, based on a EBioMedicine paper published in 2020.
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Episode 984: N-acetylcysteine in Acute Liver Failure Not Caused by Acetaminophen
Pharmacy Joe
DECEMBER 18, 2024
The most common causes of acute liver failure were: viral hepatitis, drug-induced (but not from acetaminophen), auto-immune hepatitis and cause indeterminate. Treatment also was responsible for a lower length of hospital stay when compared to control. The relative risk in favor of treatment was 0.56.
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Hospital Pharmacy FAQ
RX Note
AUGUST 4, 2023
What can I expect once I entered hospital provisional registered pharmacist training? In most hospitals, you first introduction to your workplace is through an induction period during which you are shown many different areas and meet many new people. What is the career pathway of a government hospital pharmacist?
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Israeli researchers develop bio-sensing technology to predict cancer treatment response
Express Pharma
JUNE 6, 2023
A team of researchers from Ben-Gurion University of the Negev (BGU) has developed a groundbreaking bio-sensing technology that predicts the response of cancer patients to anti-PD1, an immune checkpoint inhibitor (ICI) therapy, with significantly greater accuracy than current methods. The study was led by Bar Kaufman, a talented MD-Ph.D.
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The use of genomic profiling testing to improve oncology care
pharmaphorum
SEPTEMBER 12, 2022
Reddy says one of LabCorp’s groundbreaking tests, OmniSeq INSIGHT, is an “all-in-one test that includes comprehensive genomics and immune profiling from a single tissue sample to identify all FDA-approved therapeutics, confirm immunotherapy eligibility for a patient, and identify appropriate nearby clinical trials.”.
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Regeneron tests COVID-19 antibody therapy in UK’s RECOVERY trial
pharmaphorum
SEPTEMBER 16, 2020
RECOVERY (Randomised Evaluation of COVid-19 thERapY) trial is being conducted in NHS hospitals and has already demonstrated the benefits of dexamethasone as a treatment for COVID-19, showing the cheap steroid cut recovery times and reduced mortality.
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