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COVID-19 Hospital Burden Associated With Increased Inpatient Adverse Events Among Patients With and Without COVID-19

Pharmacy Times

High COVID-19 hospital caseload strain led to increases in inpatient adverse events among patients both with and without SARS-CoV-2 infection.

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Episode 925: What are the risk factors for serious and general opioid-related adverse drug events?

Pharmacy Joe

In this episode, I’ll discuss an article about risk factors for serious and general opioid-related adverse drug events. Episode 925: What are the risk factors for serious and general opioid-related adverse drug events? The patient mix was roughly 2.5:1 1 in favor of surgical to medical patients.

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Episode 999: Is This Study a Breakthrough for Antimicrobial Stewardship?

Pharmacy Joe

vs 11.8%, but adverse medication event rates were higher after delayed broad-spectrum therapy at 8.4% The authors concluded: On average, among a large sample of adult inpatients who ultimately received broad-spectrum antibiotic therapy, delaying initiation of a broad-spectrum antibiotic was not associated with worse outcomes.

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Episode 918: What Happens If You Give a Cephalosporin to a Patient With Moderate, Severe, or Unknown Beta-Lactam Allergy?

Pharmacy Joe

Furthermore, even in the event of a true and serious allergy to penicillin, cross-allergenicity with cephalosporins is low and the reaction is mediated by B-cell memory which fades over time, often within 10 years. He experienced a rash to the piperacillin-tazobactam as an inpatient. She experienced itching in the ED.

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Episode 981: Tranexamic Acid to Control Iatrogenic Bleeding During Flexible Bronchoscopy

Pharmacy Joe

The authors did not observe any adverse events in either group that were judged to be drug-related. Given equal efficacy and adverse event rates, a preference should be given to the less expensive medication however the stocking of tranexamic acid on bronchoscopy carts may still be justified.

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Episode 987: What dose of cefazolin is recommended for a CNS infection?

Pharmacy Joe

With the long duration of therapy needed for CNS infections, adverse events like elevated serum transaminases, neutropenia, and interstitial nephritis can frequently complicate therapy. In addition, nafcillin requires administration every 4 hours which adds to the burden of care.

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Episode 1007: What the New SCCM Sedation Guidelines Say About Melatonin

Pharmacy Joe

This data was judged to have a low certainty of providing these positive effects, however there is also a low risk of adverse events from melatonin use in ICU patients. In addition, 3 RCTs were pooled together to determine that melatonin improved patients perceptions of sleep quality while in the ICU.