This site uses cookies to improve your experience. To help us insure we adhere to various privacy regulations, please select your country/region of residence. If you do not select a country, we will assume you are from the United States. Select your Cookie Settings or view our Privacy Policy and Terms of Use.
Cookie Settings
Cookies and similar technologies are used on this website for proper function of the website, for tracking performance analytics and for marketing purposes. We and some of our third-party providers may use cookie data for various purposes. Please review the cookie settings below and choose your preference.
Used for the proper function of the website
Used for monitoring website traffic and interactions
Cookie Settings
Cookies and similar technologies are used on this website for proper function of the website, for tracking performance analytics and for marketing purposes. We and some of our third-party providers may use cookie data for various purposes. Please review the cookie settings below and choose your preference.
Strictly Necessary: Used for the proper function of the website
Performance/Analytics: Used for monitoring website traffic and interactions
In this episode, I’ll discuss an article about risk factors for serious and general opioid-related adverse drug events. Episode 925: What are the risk factors for serious and general opioid-related adverse drug events? The patient mix was roughly 2.5:1 1 in favor of surgical to medical patients.
vs 11.8%, but adverse medication event rates were higher after delayed broad-spectrum therapy at 8.4% The authors concluded: On average, among a large sample of adult inpatients who ultimately received broad-spectrum antibiotic therapy, delaying initiation of a broad-spectrum antibiotic was not associated with worse outcomes.
Furthermore, even in the event of a true and serious allergy to penicillin, cross-allergenicity with cephalosporins is low and the reaction is mediated by B-cell memory which fades over time, often within 10 years. He experienced a rash to the piperacillin-tazobactam as an inpatient. She experienced itching in the ED.
The authors did not observe any adverse events in either group that were judged to be drug-related. Given equal efficacy and adverse event rates, a preference should be given to the less expensive medication however the stocking of tranexamic acid on bronchoscopy carts may still be justified.
With the long duration of therapy needed for CNS infections, adverse events like elevated serum transaminases, neutropenia, and interstitial nephritis can frequently complicate therapy. In addition, nafcillin requires administration every 4 hours which adds to the burden of care.
This data was judged to have a low certainty of providing these positive effects, however there is also a low risk of adverse events from melatonin use in ICU patients. In addition, 3 RCTs were pooled together to determine that melatonin improved patients perceptions of sleep quality while in the ICU.
In this episode, I’ll discuss an article about serious and general opioid-related adverse drug events. Episode 686: What are the risks for serious and general opioid-related adverse drug events? The authors found that patients at high risk for severe opioid-related adverse events had COPD, neurological failure, or renal disease.
Only 1 of the 5 studies suggested an increase in adverse events with treatment, and this was only nausea and vomiting related events. If you like this post, check outmy book A Pharmacists Guide to Inpatient Medical Emergencies: How to respond to code blue, rapid response calls, and other medical emergencies. <–
Any grade neurologic events (NEs) occurred in 31 per cent of patients, with Grade > 3 NEs occurring in 10 per cent of patients. Patients in the TRANSCEND FL study were treated in the inpatient and outpatient setting. Treatment process includes leukapheresis, manufacturing, administration, and adverse event monitoring.
The authors’ primary endpoint was the rate of adverse events following IVP administration of antibiotics. There were only 10 adverse events observed, half of which were allergic reactions and therefore not related to IVP administration. Results The study evaluated 1000 patients who received IVP antibiotics.
In this episode, I’ll discuss how to predict the pharmacotherapy needs of your patient and team during an inpatient medical emergency. If you like this post, check out my book – A Pharmacist’s Guide to Inpatient Medical Emergencies: How to respond to code blue, rapid response calls, and other medical emergencies. <–
Secondary outcomes included measures of patient distress, postprocedure length of stay, and adverse events. There was only 1 adverse event in the entire study – a patient who received 4 mcg/kg experienced a decrease in oxygen saturation which resolved after head repositioning.
Based on this data, in the rare event I am using ketamine for refractory status epilepticus, I use a 2 or 3 mg/kg IV bolus followed by an infusion of at least 1 mg/kg/hr. To access my free download area with 20 different resources to help you in your practice, go to pharmacyjoe.com/free.
In the NEJM study, each of the three medications led to seizure cessation and improved alertness by 60 minutes in approximately half the patients, and the three medications were associated with similar incidences of adverse events.
No patients had hemodynamic instability and there was no difference in adverse events between groups. If you like this post, check out my book – A Pharma cist’s Guide to Inpatient Medical Emergencies: How to respond to code blue, rapid response calls, and other medical emergencies. <–
Methylprednisolone 40 mg IV once 4 hours prior to extubation The authors of a recent meta-analysis concluded: Administration of prophylactic corticosteroids before elective extubation was associated with significant reductions in the incidence of post-extubation airway events and reintubation, with few adverse events.
Adverse events did not differ between tranexamic and placebo groups, including cerebral ischemia and deep venous thrombosis events. absolute reduction in rebleeding events. There was also no effect of treatment on poor functional outcome. The only difference that was in favor of the tranexamic acid group was an 8.7%
The incidence of adverse events and serious adverse events were comparable between the two groups. If you like this post, check out my book – A Pharmacist’s Guide to Inpatient Medical Emergencies: How to respond to code blue, rapid response calls, and other medical emergencies. <– aeruginosa vs placebo group at day 29.
The authors sought to compare the efficacy and adverse event profile of 1,000 mg of intravenous acetaminophen to that of 0.5 The secondary outcomes included the need for additional analgesic medication and any adverse events that could be related to the study medication. or more on the 0 to 10 pain scale.
The authors evaluated the groups for differences in pain scores at 30 minutes post administration, the need for rescue analgesia, adverse event rates, and the difference in pain scores at 15, 30, 60, 90, and 120 minutes. 75 patients were given a single dose of 0.3 mg/kg of intravenous ketamine and 75 were given 0.75 out of 10 for both groups.
No lower extremity DVTs or suspected VTE events occurred. Two patients (6%) had significant bleeding events. If you like this post, check out my book – A Pharmacist’s Guide to Inpatient Medical Emergencies: How to respond to code blue, rapid response calls, and other medical emergencies. <–
The authors’ primary endpoint was the rate of adverse events following IVP administration of antibiotics. There were only 10 adverse events observed, half of which were allergic reactions and therefore not related to IVP administration. Results The study evaluated 1000 patients who received IVP antibiotics.
The authors sought to compare the efficacy and adverse event profile of 1,000 mg of intravenous acetaminophen to that of 0.5 The secondary outcomes included the need for additional analgesic medication and any adverse events that could be related to the study medication. or more on the 0 to 10 pain scale.
Methylprednisolone 40 mg IV once 4 hours prior to extubation The authors of a recent meta-analysis concluded: Administration of prophylactic corticosteroids before elective extubation was associated with significant reductions in the incidence of post-extubation airway events and reintubation, with few adverse events.
The authors note this data is not generalizable to children or patients at higher risk of adverse events. If you like this post, check out my book – A Pharma cist’s Guide to Inpatient Medical Emergencies: How to respond to code blue, rapid response calls, and other medical emergencies. <–
Subscribe on iTunes , Android , or Stitcher Patients with acute ischemic stroke are at risk of conversion to hemorrhagic stroke for a period of time after the initial event. Episode 753: Should DOACs be Started Early or Late in Ischemic Stroke Patients with AFib? The primary outcome occurred in 6.9% of the early group and 8.7%
Only 1 of the 5 studies suggested an increase in adverse events with treatment, and this was only nausea and vomiting related events. If you like this post, check out my book – A Pharmacist’s Guide to Inpatient Medical Emergencies: How to respond to code blue, rapid response calls, and other medical emergencies. <–
The safety outcomes were s kidney adverse events and serious adverse events until day 7 or hospital discharge. The rate of hematoma expansion, death, and severe disability was not significantly different between groups, nor was the rate of kidney serious adverse events. compared to just 6.8% with a relative risk of 3.22.
The safety outcomes were s kidney adverse events and serious adverse events until day 7 or hospital discharge. The rate of hematoma expansion, death, and severe disability was not significantly different between groups, nor was the rate of kidney serious adverse events. compared to just 6.8% with a relative risk of 3.22.
The primary outcome was a composite of death, major cardiovascular events (stroke, transient ischemic attack, systemic embolism, valve thrombosis, or hospitalization for heart failure), or major bleeding at 12 months. To access my free download area with 20 different resources to help you in your practice, go to pharmacyjoe.com/free.
While management of anaphylaxis from sugammadex is no different than from other antigens, clinicians using sugammadex should be especially alert to the possibility of a serious reaction occurring within the first few minutes after administration so that in the rare event anaphylaxis occurs, recognition and treatment is not delayed.
The incidence of adverse events and serious adverse events were comparable between the two groups. If you like this post, check out my book – A Pharmacist’s Guide to Inpatient Medical Emergencies: How to respond to code blue, rapid response calls, and other medical emergencies. <– aeruginosa vs placebo group at day 29.
And with more medicines, the risk of interaction and adverse drug events increases. 2019) 1 , by using clinical pharmacists to prevent Treatment-Related Problems (TRPs) leads to the benefit of almost 6 times the cost of the program because of intervention and avoiding preventable Adverse Drug Events (ADEs). The study by Schurrer et al.
While aspiration was not previously addressed head-on in CAP guidelines, new data prompted the 2019 IDSA CAP guideline authors to include the following question: Question 10: In the Inpatient Setting, Should Patients with Suspected Aspiration Pneumonia Receive Additional Anaerobic Coverage beyond Standard Empiric Treatment for CAP?
Treatment with insulin continued for 72 hours, and the patient achieved a full neurologic recovery other than amnesia of the event. If you like this post, check out my book – A Pharma cist’s Guide to Inpatient Medical Emergencies: How to respond to code blue, rapid response calls, and other medical emergencies. <–
The authors note this data is not generalizable to children or patients at higher risk of adverse events. If you like this post, check out my book – A Pharma cist’s Guide to Inpatient Medical Emergencies: How to respond to code blue, rapid response calls, and other medical emergencies. <–
mL racemic epinephrine in the event a patient develops post-extubation stridor. If you like this post, check out my book – A Pharmacist’s Guide to Inpatient Medical Emergencies: How to respond to code blue, rapid response calls, and other medical emergencies. <– To get immediate access, go to pharmacyjoe.com/academy.
The only difference between infiltration and extravasation is that the former is done with therapeutic intent (such as lidocaine for local anesthesia) and the latter is an unintended event with a harmful medication. Nonpharmacologic treatment of extravasation involves the application of cold or warm compresses to the affected area.
The only difference between infiltration and extravasation is that the former is done with therapeutic intent (such as lidocaine for local anesthesia) and the latter is an unintended event with a harmful medication. Nonpharmacologic treatment of extravasation involves the application of cold or warm compresses to the affected area.
mL racemic epinephrine in the event a patient develops post-extubation stridor. If you like this post, check out my book – A Pharmacist’s Guide to Inpatient Medical Emergencies: How to respond to code blue, rapid response calls, and other medical emergencies. <– To get immediate access, go to pharmacyjoe.com/academy.
Treatment with insulin continued for 72 hours, and the patient achieved a full neurologic recovery other than amnesia of the event. If you like this post, check out my book – A Pharma cist’s Guide to Inpatient Medical Emergencies: How to respond to code blue, rapid response calls, and other medical emergencies. <–
Secondary outcomes were the rate of clinical recovery, the incidence of drug-related adverse events, ICU and hospital mortality. If you like this post, check out my book – A Pharmacist’s Guide to Inpatient Medical Emergencies: How to respond to code blue, rapid response calls, and other medical emergencies. <–
in the study however none of the adverse events were rated as severe. If you like this post, check out my book – A Pharmacist’s Guide to Inpatient Medical Emergencies: How to respond to code blue, rapid response calls, and other medical emergencies. <– Respiratory depression did occur at a rate of 7.7%
We organize all of the trending information in your field so you don't have to. Join 11,000+ users and stay up to date on the latest articles your peers are reading.
You know about us, now we want to get to know you!
Let's personalize your content
Let's get even more personalized
We recognize your account from another site in our network, please click 'Send Email' below to continue with verifying your account and setting a password.
Let's personalize your content