Sat.Oct 07, 2023 - Fri.Oct 13, 2023

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Research in space yields clues about boosting bone health on Earth

PharmaVoice

A study aimed at helping astronauts decrease bone loss could open the door to novel osteoporosis meds.

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Opinion: Yes, everyone should get an updated Covid-19 vaccine

STAT

Last month, the Centers for Disease Control and Prevention recommended that everyone in the U.S. 6 months and older receive an updated Covid vaccine targeting the XBB.1.5 variant. Since then, some notable voices, including Paul Offit , have publicly questioned whether the updated vaccine is needed for those who are not in a high-risk group. He recently wrote, “At this point in the pandemic, it is hard to make a case for vaccinating everyone.

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ACMT Toxicology Visual Pearls: A Meal Worth Dying For

ALiEM - Pharm Pearls

What is the most common primary cause of death from ingesting the pictured marine animal? Acute liver failure Acute renal failure Coagulopathy and DIC Respiratory failure Status epilepticus [Image from Canstockphoto] Reveal the Answer 4. Respiratory Failure The pufferfish, considered a delicacy in multiple countries, contains tetrodotoxin which causes sodium channel blockade and can lead to muscle paralysis, respiratory failure, and death.

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A decade later, biotech’s CRISPR revolution is still going strong

BioPharma Dive

Once the specialty of a few select drugmakers, CRISPR gene editing is now an essential technology for a growing group of biotechs, many led by former students of the field's pioneering scientists.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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To close the pediatric innovation gap, this biotech has to think differently

PharmaVoice

Day One Biopharmaceuticals is bucking the cancer drug development trend by working with children and adults simultaneously.

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STAT+: In major test for eGenesis, gene-edited pig kidneys kept monkeys alive for more than two years

STAT

Scientists at a Massachusetts-based biotechnology company and their academic research partners reported Wednesday that an engineered breed of miniature pig containing up to 69 genetic changes produced kidneys that functioned well in monkeys for an average of 176 days and in one animal for more than two years. The results, published in Nature , are an encouraging sign that the long-struggling science of xenotransplantation might one day become a medical reality.

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More Trending

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Pfizer to cut costs, lay off staff on waning demand for COVID products

BioPharma Dive

Sales of Pfizer's antiviral Paxlovid and shot Comirnaty have been slower than it anticipated, while a shift to the commercial market for the antiviral has been delayed.

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A biotech ‘tuning’ the genome for a potentially safer gene therapy

PharmaVoice

Tune Therapeutics is hoping to overcome the pitfalls of CRISPR-style treatments with epigenetic editing.

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STAT+: Like a vampire, some cancer cells can suck the energy source from immune cells

STAT

As elite hunters of the immune system, T cells are constantly prowling our bodies for diseased cells to attack. But when they encounter a tumor, something unexpected can happen. New research shows that some cancer cells can fire a long nanotube projection into the T cell that, like a vampire’s fang, sucks energy-creating mitochondria from the immune cell, turning the predator into prey.

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An Evolving ‘Opinion’ Landscape: New Paths—and Synergies—for Pharma KOLs & DOLs

PharmExec

Industry experts discuss the relationship between digital and traditional (key) opinion leaders and how companies are adjusting their strategies to harness the unique brand engagement benefits each role can provide in driving better patient outcomes.

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Why Every Small Business Needs an HCM Solution: A Comprehensive Guide

Managing HR tasks like payroll, compliance, and employee data can overwhelm small businesses. That’s where a Human Capital Management (HCM) solution comes in. Our eBook, Why Every Small Business Needs an HCM Solution: A Comprehensive Guide , shows how an HCM system automates tedious processes, ensuring your business stays compliant and efficient. You’ll learn how to simplify payroll, eliminate costly errors, and empower your employees with self-service tools.

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After summer slump, biotech M&A has a good week

BioPharma Dive

There have been few bigger-ticket acquisitions recently. But a string of deals announced in early October may affirm the forecasts of analysts who expect M&A to tick up in the coming months.

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AstronauTx completes £48m series A financing for Alzheimer’s disease

Pharma Times

The financing will support the biotech’s clinical study of people with AD as a lead programme - News - PharmaTimes

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Treating Rural America: The new country doctors

STAT

Family medicine physician Olusunmisola Oyesiku always thought she would practice in a big city, but after going through her family residency program at the University of Alabama in Selma, she ended up falling in love with rural medicine. The Selma program is one of a small, but growing, number of residencies in the country that places residents entirely in rural medical settings.

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Roche multiple sclerosis subcutaneous injection: late-breaking data

European Pharmaceutical Review

Late-breaking data from Roche’s Phase III OCARINA II study have revealed that OCREVUS® (ocrelizumab) subcutaneous injection was comparable to IV infusion in providing near-complete suppression of MRI brain lesion activity over 24 weeks, for relapsing or primary progressive multiple sclerosis (RMS or PPMS) patients. OCREVUS is a humanised monoclonal antibody designed to target CD20-positive B cells, which are thought to be a key contributor to myelin and axonal (nerve cell) damage, noted Roche.

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Best Practices to Streamline Compensation Management: A Foundation for Growth

Speaker: Joe Sharpe and James Carlson

Payroll optimization can be one of the most time-consuming and complex factors of small business management. Yet, organizations that crack the code on streamlining employee compensation often discover innovative avenues for growth. With the right strategies in place, outsourcing and streamlining payroll processes can result in substantial time and resource savings.

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Bayer opens California plant to make cell therapies

BioPharma Dive

The pharma plans for the new Berkeley facility to produce clinical, and potentially commercial, supplies of a Parkinson’s disease cell therapy being tested by its subsidiary BlueRock.

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UKRI awards £41m to enhance UK research and innovation

Pharma Times

The scheme will help ten projects establish research and innovation clusters - News - PharmaTimes

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The ‘model-eat-model world’ of clinical AI: How predictive power becomes a pitfall

STAT

A growing number of AI tools are being used to predict everything from sepsis to strokes, with the hope of accelerating the delivery of life-saving care. But over time, new research suggests, these predictive models can become a victim of their own success — sending their performance into a nosedive and generating inaccurate, potentially harmful results.

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Follicular lymphoma BTK inhibitor recommended by CHMP

European Pharmaceutical Review

The Committee for Medicinal Products for Human Use (CHMP) has recommended approval of BRUKINSA ® (zanubrutinib), a Bruton’s tyrosine kinase inhibitor (BTKi), in combination with obinutuzumab. BeiGene’s anti-cancer treatment is indicated for adults with relapsed or refractory (R/R) follicular lymphoma (FL) who have received at least two prior lines of systemic therapy.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Novo Nordisk’s Ozempic shows kidney benefit in large study

BioPharma Dive

The finding from the study of its diabetes drug, which Novo didn’t detail, could help the company in its competition with rival drugmaker Eli Lilly.

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PulmCrit Blogitorial – Why the new brain death guidelines are unacceptable

EMCrit Project

Hello fellow nerds, let's take a look at the new American Association of Neurology (AAN) brain death guidelines. Instead of a tweetorial, I'll jot my thoughts here, so they're accessible to everyone. Disclaimer: the following discussion applies only to adult medicine. Most of these guidelines are consistent with the 2020 World Brain Death Project, so […] EMCrit Project by Josh Farkas.

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He was named a MacArthur ‘genius’ fellow for research on gene regulation, but still has imposter syndrome

STAT

The youngest of this year’s class of MacArthur “genius grant” fellows, 35-year-old Jason Buenrostro was just a graduate student when he pioneered a technique that’s become a mainstay for studying how cells regulate gene expression. While doing his doctoral work at Stanford University, with geneticists William Greenleaf and Howard Chang, he developed the assay for transposase-accessible chromatin, or ATAC-seq, a highly sensitive and accurate method for identifying regi

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Pharma pushes for UK medicine scheme revision

European Pharmaceutical Review

According to the Association of the British Pharmaceutical Industry (ABPI), a consultation by the UK Government proposing radical changes to the Statutory Scheme for branded medicines has been heavily criticised by the pharmaceutical industry. The fundamental concern, ABPI highlighted, is the proposed continuation of an arbitrary cap on growth for branded medicines in the UK, which has led to soaring revenue clawbacks in the country.

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Enhance Healthcare Efficiency With Top Payroll & HCM Services

Running a healthcare facility requires precision and care, not just for patients but also for your staff. Our guide, "A Buyer’s Guide to Payroll & HCM Services," helps healthcare providers choose the best provider. Efficient payroll management ensures timely, accurate payments, critical for maintaining staff morale and trust. Compliance support helps navigate complex healthcare regulations and avoid costly fines.

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Kyowa Kirin to acquire Orchard Therapeutics in deal worth $477m

Pharma Times

The deal gives Kyowa access to a therapy for early-onset metachromatic leukodystrophy - News - PharmaTimes

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‘Project NextGen’ picks new mRNA, intranasal COVID vaccines for funding

BioPharma Dive

The awards, to biotechs Gritstone, Codagenix and CastleVax, are part of the program’s plan to develop vaccines with broader or longer-lasting benefits.

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‘What I’m most proud of’: Nick Jonas talks about managing diabetes, his career, and building community

STAT

LAS VEGAS – Nick Jonas is a global superstar behind electrifying earworms like “Jealous,” “Chains,” and “Sucker,” one-third of the illustrious band The Jonas Brothers — and also a person who lives with type 1 diabetes. He took time out of his world tour to sit down with STAT’s Nicholas St.

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Novel anti-epileptic drug demonstrates efficacy

European Pharmaceutical Review

A new drug, part of a class of chemicals called potassium-channel openers, has demonstrated potential in offering relief to patients with focal epilepsy. Key data from a clinical trial, published in a report in JAMA Neurology, has revealed that adding the drug XEN1101 to a patient’s current antiseizure treatments saw a 33 percent to 53 percent drop in monthly seizures, depending on dose.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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UCL researchers recommend AI language models for schizophrenia diagnosis

Pharma Times

Automated analysis of language could help diagnose and assess psychiatric conditions - News - PharmaTimes

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How to Use BoardVitals to Prepare for the Longitudinal Knowledge Assessment 

Board Vitals - Pharmacist

Several certifying boards, including the ABIM, have rolled out a new way for practitioners to maintain their certification. In addition to the traditional 10-year maintenance of certification (MOC) exam, the 5-year Longitudinal Knowledge Assessment (LKA) is available for many specialties. Despite its open-book format, the LKA should not be taken lightly.

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STAT+: Scientists have mapped the human brain in unprecedented detail. They’re just getting started

STAT

The brain remains both the body’s most important organ and its least understood. But a draft atlas of the human brain published on Thursday gives scientists important insights into how it works and may pave the way for big advances in disease treatment and diagnosis. This brain map, pieced together by hundreds of researchers from San Diego to Seattle to Stockholm, is essentially a cellular “parts list” of the human brain and a guide to how those pieces are arranged and work

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ECNP 2023: new esketamine NS safety data for depression

European Pharmaceutical Review

The Janssen Pharmaceutical Companies of Johnson & Johnson has revealed that according to new safety data, SPRAVATO ® (esketamine nasal spray [NS]) has demonstrated superior efficacy compared to quetiapine extended-release (Quetiapine XR) for treatment-resistant depression (TRD). This treatment is an antagonist of the N-methyl-D-aspartate (NMDA) glutamate receptor.

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UKRI awards three projects £25m for vaccine development

Pharma Times

The projects will support the development of new and longer-lasting vaccines - News - PharmaTimes

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