Sat.Feb 25, 2023 - Fri.Mar 03, 2023

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Opinion: How physician wellness programs keep doctors captive

STAT

The American College of Surgeons recently announced its new well-being initiative for surgeons. This wellness program has lofty goals: [The ACS] recognizes the need to foster well-being, resilience, and work-life integration for all surgeons, regardless of their career stage. Fostering the growth of both the surgical expertise and the person as a whole is paramount.

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11 Tips to Improve Epistaxis Management in the Emergency Department

ALiEM - Pharm Pearls

Managing epistaxis is often challenging, time-consuming, and takes practice. Even under the best circumstances, epistaxis often results in return visits for rebleeding and poor outcomes. Rarely should you do “nothing” for adults who present to the ED with or following epistaxis. If it produced enough blood to seek care (even without hemodynamic compromise), epistaxis frequently recurs even if currently resolved.

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As clinical trials face a hiring crunch, here’s how research organizations can pivot

PharmaVoice

Staffing shortages are causing inefficiencies in clinical trials, but one leading CRO is finding ways to adapt.

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Why Congress should prioritize fixing the 340B program

PhRMA

Nearly all Americans nationwide agree: Lowering out-of-pocket costs for health care should be a top priority for policymakers. Luckily, there are commonsense policies Congress could implement to meaningfully address the cost burdens Americans face. These include things like making sure patients aren’t paying more for their medicines than their health insurance company or requiring first-dollar coverage, so insurance companies cover the cost of certain lifesaving medicines from day one of the pla

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Report: Obesity could cost the world over $4 trillion a year by 2035

STAT

The costs of obesity are projected to soar globally, in step with rising prevalence, according to a new report from the World Obesity Federation, the only group focused solely on tracking global obesity trends and a partner of the World Health Organization. Over half the world’s population will be either overweight or have obesity by 2035, the report projected, while the economic impact of a high BMI could reach $4.32 trillion annually, if current trends continue and policy inertia around

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SAEM Clinical Images Series: A Rare Cause of Post-traumatic Neck Pain

ALiEM - Pharm Pearls

A 15-year-old male presents to the pediatric Emergency Department (ED) for evaluation of neck pain for three weeks. The patient is vague as to the development of his symptoms, but his mother reveals patient was assaulted by peers three weeks ago and has had progressively worsening neck pain and stiffness. The patient states symptoms have gotten to the point where he is unable to turn his head but denies fevers, chills, nausea, vomiting, focal weakness, or sensory changes.

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New workflow for the analysis of mRNA therapeutics

European Pharmaceutical Review

Large RNA is rapidly emerging as a new class of therapeutics. Nowhere is this more publicly evident than in the development, regulatory approval, and efficacious use of mRNA‑based vaccines for COVID-19. Beyond the high-profile COVID-19 vaccines, mRNA therapeutics are crucial in applications such as protein replacement therapies and regenerative medicine.

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STAT Madness 2023

STAT

Welcome to STAT Madness, a bracket-style contest to find the best innovation in science and medicine. Click on each matchup for a short summary of each school’s pioneering research. Then pick your favorites. Help us crown a champ!

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Is the microbiome therapy hype up for a reckoning?

Pharmaceutical Technology

In the last decade, the idea of tapping into the gut has attracted much interest from investors and the public, but recent years have showed that a lot more work needs to be done before such treatments enter the mainstream. This is largely due to the FDA’s rigorous approach to the safety of microbiome therapeutics, which has manifested in clinical holds, resulting in delays that have dimmed the enthusiasm in the space in recent times.

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Woman of the Week: Denali Therapeutics’ Cindy Dunkle

PharmaVoice

As chief people officer, Dunkle is harnessing the company’s unique culture to foster innovation.

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Why Every Small Business Needs an HCM Solution: A Comprehensive Guide

Managing HR tasks like payroll, compliance, and employee data can overwhelm small businesses. That’s where a Human Capital Management (HCM) solution comes in. Our eBook, Why Every Small Business Needs an HCM Solution: A Comprehensive Guide , shows how an HCM system automates tedious processes, ensuring your business stays compliant and efficient. You’ll learn how to simplify payroll, eliminate costly errors, and empower your employees with self-service tools.

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Overcoming barriers to capturing data in a laboratory

European Pharmaceutical Review

What are the key data integration challenges faced in labs? At the risk of citing a circular issue, I would say two key challenges are both lack of data standards and a saturation of data standards. Other challenges include proprietary data formats, lack of up-to‑date equipment and inconsistent datasets. An important aspect of data integration is having different datasets in the same format (or at least a format that can be converted to match the other).

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The FDA has cleared the first home flu and Covid test — but its maker just declared bankruptcy

STAT

On Friday, the Food and Drug Administration issued an emergency authorization for the first at-home test that can detect flu and Covid-19 — but for the test’s maker, Lucira, the long-anticipated authorization may have taken too long. The company filed for bankruptcy on Feb. 22, directly blaming the “protracted” FDA authorization process for the over-the-counter combination test for its financial troubles.

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Celebrating 40 years of the Orphan Drug Act on Rare Disease Day

PhRMA

For over a decade, Rare Disease Day has been celebrated on February 28 to raise awareness and generate change for the more than 30 million patients in the U.S. living with a rare disease. This year’s Rare Disease Day is particularly special because this year also marks the 40 th anniversary of the Orphan Drug Act (ODA), allowing us to celebrate all the progress that’s come to patients because of it.

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Launched with a ‘pioneer’ in RNA, aTyr Pharma is charting a new course in immunology

PharmaVoice

With a focus on rare and hard-to-treat diseases, aTyr is banking on its head start in tRNA and vast IP portfolio to build a billion-dollar company.

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Best Practices to Streamline Compensation Management: A Foundation for Growth

Speaker: Joe Sharpe and James Carlson

Payroll optimization can be one of the most time-consuming and complex factors of small business management. Yet, organizations that crack the code on streamlining employee compensation often discover innovative avenues for growth. With the right strategies in place, outsourcing and streamlining payroll processes can result in substantial time and resource savings.

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US FDA approves Reata Pharmaceuticals’ SKYCLARYS for Friedreich’s ataxia

Pharmaceutical Technology

The US Food and Drug Administration (FDA) has approved Reata Pharmaceuticals ’ oral, once-daily medication SKYCLARYS (omaveloxolone) to treat Friedreich’s ataxia patients. SKYCLARYS is indicated to treat the ultra-rare, inherited neurodegenerative disorder in 16 years and above-aged adults and adolescents in the US. SKYCLARYS is the first approved treatment in Friedrich’s Ataxia and marks a milestone for drug development in this complex disease.

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Same patient, same drug, same insurer — coverage denied

STAT

Janice Morales-Ferrer is a planner. It’s helped her get ahead in her career and in raising three young kids. But it’s hard to plan when you’ve got a rare disease, especially one with no standard treatment regimen or predictable outcome. “I’m a data-driven person,” said the 46-year-old Boston area resident. “It’s frustrating for me to not be able to plan how long I can live for my kids.

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Cell therapy first for chronic heart failure

European Pharmaceutical Review

The largest cell therapy trial to date for chronic heart failure due to low ejection fraction (EF), has shown that mesenchymal precursor cells (MPCs) have potential for the first time to address inflammation. “This study examined the effects of [MPCs] a specific type of stem cell obtained from the bone marrow of healthy adult donors,” the study’s lead author, Dr Emerson C Perin, PhD, FACC, Medical Director at The Texas Heart Institute shared with EPR.

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The ‘recovering academic’ leading Allogene to the next stage of cell therapy

PharmaVoice

Zachary Roberts joined Allogene at the beginning of this year to lead the company's R&D and bring allogeneic cell therapy to the forefront.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Double win for StudyKIK's oncology and cash apps helping trial patients

Outsourcing Pharma

Year on year, the SCOPE summit brings thousands of people working in the pharma field together and the last one attracted more than 2,300 leaders in clinical operations and research.

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What the dogs of Chernobyl can teach us about life at the edge

STAT

You’d think an irradiated wasteland would be a poor place to make a home, but some animals beg to differ. Since the Chernobyl nuclear meltdown 37 years ago, both wild animals and free-roaming domesticated dogs have, to the surprise and delight of environmentalists, flocked to and flourished in the evacuated,1,000 square mile zone surrounding the plant.

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New purification method could enhance protein drug manufacturing

European Pharmaceutical Review

In a recent study, Massachusetts Institute of Technology (MIT) researchers developed a new purification method to cut the costs of manufacturing protein drugs. The engineers used bioconjugate-functionalised nanoparticles to quickly and inexpensively isolate proteins from a bioreactor. Producing biologics by isolating proteins Biologics like antibodies and other protein-based drugs are produced by living cells such as yeast in large bioreactors.

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PharmaVoice 100 honorees: Where are they now?

PharmaVoice

How some of our past PharmaVoice 100 honorees are transforming the life sciences industry in new roles.

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Enhance Healthcare Efficiency With Top Payroll & HCM Services

Running a healthcare facility requires precision and care, not just for patients but also for your staff. Our guide, "A Buyer’s Guide to Payroll & HCM Services," helps healthcare providers choose the best provider. Efficient payroll management ensures timely, accurate payments, critical for maintaining staff morale and trust. Compliance support helps navigate complex healthcare regulations and avoid costly fines.

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Will Face to Face Communication Fade in a Digital World?

Pulses

By: Jaclyn Boyle, MS, MBA, BCACP and Jonathan Lang, PharmD Candidate 2023 With the technological advances of today’s age, will students lose the ability to communicate face to face (F2F)? The newly revised AACP Curriculum Outcomes and Entrustable Professional Activities (COEPA) stress the importance of communication. COEPA 2.2 states that students should “actively engage, listen, and communicate verbally, nonverbally, and in writing when interacting with or educating an individual, group,

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STAT+: CRISPR patent fight redux? A new battle is brewing among biotechs over next-gen gene-editing tools

STAT

Genome editing summits are generally friendly, nerdy affairs, but for a moment at a Lisbon hotel last June, the conversation at the FASEB genome engineering conference grew tense. Tessera Therapeutics chief scientist Michael Holmes had just finished presenting a much-anticipated peek at a technology the company had previously said could “ revolutionize genetic medicine ” and “cure nearly any genetic disease.

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FDA panel backs GSK RSV vaccine ahead of approval

Pharmafile

Yesterday, GSK shared that an advisory committee from the FDA voted in support of its respiratory syncytial virus (RSV) vaccine candidate for older adults. This support is ahead of an official FDA approval for the company’s vaccine. GSK has shared that a final decision is expected to be made by the FDA ahead of the 3 May.

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Prioritising for a data-driven 2023

European Pharmaceutical Review

Last year was another challenging one for the pharmaceutical industry. On top of residual pandemic-related challenges and supply chain issues, the ever-adapting regulatory environment has continued to set new standards and enforce new requirements. This article explores some of the most notable developments of 2022, and areas that are likely to be a growing focus for data-driven transformation in 2023.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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What The NAPLEX 2022 Pass Rate Tells Us About 2023

Med Ed 101

I’ve followed the NAPLEX exam since I graduated in 2009. The NAPLEX was relatively easy from my experience and the experience of many of my classmates. The pass rate that year was an indicator that the NAPLEX was not very difficult. That is not the case anymore. Just looking at the California Board of Pharmacy […] The post What The NAPLEX 2022 Pass Rate Tells Us About 2023 appeared first on Med Ed 101.

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One type of artificial sweetener may increase heart attack risk, preliminary study says

STAT

The sweetener erythritol, which is becoming increasingly popular in snack bars and low-sugar ice cream substitutes, may increase the risk of heart attacks and strokes, according to a paper published Monday in the journal Nature Medicine. Outside experts who reviewed the findings emphasized that more evidence is needed, with some raising concerns that the results of the study could be due to other factors that make it appear the sweetener causes risks when it does not.

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Double win for StudyKIK's oncology and cash apps helping trial patients

Outsourcing Pharma

Year on year, the SCOPE summit brings thousands of people working in the pharma field together and the last one attracted more than 2,300 leaders in clinical operations and research.

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NITROSAMINES: Where now?

European Pharmaceutical Review

IN THE INITIAL PHASE of the N -nitrosamines crisis, the issue was the formation of small alkyl chain N -nitrosamines, eg, N-nitrosodimethylamine (NDMA) and N- nitrosodiethylamine (NDEA) (see Figure 1 ) in active pharmaceutical ingredients (API). 1,2 Although the presence of N -nitrosamines came as a huge surprise to industry and regulators alike, both sides rapidly responded and strategies were introduced to address the problem. 3 Figure 1 : Structures of NDMA (ChemSpider Reference 5894) and NDE

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US FDA approves Regeneron-Sanofi’s Kevzara to treat polymyalgia rheumatica

Pharmaceutical Technology

The US Food and Drug Administration (FDA) has granted approval for Regeneron Pharmaceuticals and Sanofi ’s Kevzara (sarilumab) to treat polymyalgia rheumatica (PMR) in adult patients. Kevzara has been approved as the first and only biologic indicated for PMR adult patients who did not respond to corticosteroids or who cannot tolerate corticosteroid taper.