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In this episode, I’ll discuss mannitol extravasation. Episode 514: Mannitol Extravasation Subscribe on iTunes , Android , or Stitcher When given as a bolus, mannitol is an osmotic diuretic that does not cross the blood-brain barrier. Mannitol lowers intracranial pressure by osmotically drawing free water out of the brain and into circulation where it can be eliminated.
Recently, the American College of Rheumatology released new 2020 gout guidelines. In these guidelines, there are 42 recommendations that reflect new clinical evidence since the release of the 2012 guidelines. Full text 2020 gout guidelines can be found here. One of the key highlights is the emphasis on treat-to-target urate-lowering therapy (ULT) rather than utilizing […].
We previously reported on the Ontario government’s efforts to manage the risk of drug shortages in the early days of the pandemic. Those efforts included a recommendation that pharmacies dispense no more than a 30-days’ supply of medication to patients under the Ontario Drug Benefit ( ODB ) program. Because the policy resulted in additional dispensing fees being charged to patients, the government took further regulatory action to ensure that patients would not be required to pay additional fees
It’s time for our annual Drug Channels examination of PBM drug spending reports. For 2019, we again aim our magnifying glass at the annual trend reports from the largest pharmacy benefit managers (PBMs): CVS Health, Express Scripts, and Prime Therapeutics. (See their report links below.). Once again, we find that commercial drug spending did not race higher—contrary to what you keep hearing from journalists and politicians.
Payroll compliance is a cornerstone of business success, yet for small and midsize businesses, it’s becoming increasingly challenging to navigate the ever-evolving landscape of federal, state, and local regulations. Mistakes can lead to costly penalties and operational disruptions, making it essential to adopt advanced solutions that ensure accuracy and efficiency.
In this episode, I’ll discuss an article about hydroxychloroquine for prophylaxis after high-risk Covid-19 exposure. Episode 513: Does hydroxychloroquine work for prophylaxis after high-risk Covid-19 exposure? Subscribe on iTunes , Android , or Stitcher Article A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19 Lead author: David R.
Avanafil, sildenafil, tadalafil, and vardenafil are PDE-5 inhibitors available in the USA and indicated for erectile dysfunction. PDE-5 inhibitors prevent the breakdown of cGMP and it is also one of the drug classes that interacts with nitrates. Nitrates are one of the important medications to manage angina and other cardiovascular diseases. Nitrates increase cGMP which […].
Avanafil, sildenafil, tadalafil, and vardenafil are PDE-5 inhibitors available in the USA and indicated for erectile dysfunction. PDE-5 inhibitors prevent the breakdown of cGMP and it is also one of the drug classes that interacts with nitrates. Nitrates are one of the important medications to manage angina and other cardiovascular diseases. Nitrates increase cGMP which […].
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