November, 2023

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Pharma benefited from basing business overseas. An international tax effort could spur a rethink.

BioPharma Dive

U.S. tax law changes enacted six years ago slashed large pharma companies' rates and saved them billions. Now, a push for an international floor could disrupt their R&D accounting.

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PDA sounds alarm over AI use by pharmacy students

The Pharmacist

The Pharmacists’ Defence Association (PDA) has warned pharmacy students that the use of artificial intelligence (AI) technology risks charges of plagiarism and misconduct. In its October 2023 student newsletter, the PDA highlighted a ‘concerning rise’ in the number of students using AI programmes – such as ChatGPT and QuillBot – to write or enhance assessments. […] The post PDA sounds alarm over AI use by pharmacy students appeared first on The Pharmacist.

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STAT+: U.K. approves world’s first CRISPR-based medicine, giving greenlight to therapy for sickle cell, thalassemia

STAT

LONDON — Regulators in the U.K. on Thursday approved a CRISPR-based medicine to treat both sickle cell disease and beta thalassemia, making it the world’s first therapy built on the revolutionary gene-editing technology and ushering in a new phase of genetic medicine.   The authorization of the therapy, from Vertex Pharmaceuticals and CRISPR Therapeutics, is itself not a surprise.

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AstraZeneca showed the pandemic isn’t over for immunocompromised patients. What’s next?

PharmaVoice

Dr. Paul Moss, a hematology expert in the U.K., conducted a study with AstraZeneca showing the alarming extent to which immunocompromised patients are burdened with COVID-19.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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ACMT Toxicology Visual Pearl: Poison Dart Frog

ALiEM - Pharm Pearls

The toxin from the golden poison dart frog most resembles which of the following in its mechanism of action? Botulinum toxin Bufotoxin Grayanotoxin Palytoxin Tetrodotoxin Photo adapted from Wilfried Berns (Wikimedia Commons) Reveal the Answer 3. Grayanotoxin – a sodium channel opener Background The golden poison dart frog ( Phyllobates terribilis ), often considered one of the most poisonous animals on the planet, secretes onto its skin the lipophilic alkaloid batrachotoxin , which irreversibly

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‘They thought I had cancer’: painkiller banned in UK linked to Britons’ deaths in Spain

The Guardian - Pharmaceutical Industry

Patients’ group says reactions to metamizole can cause sepsis and organ failure – and British and Irish people are at higher risk A patients group representing several British victims has launched legal action against the Spanish government over claims it failed to safeguard people against the potentially fatal side effects of one of the country’s most popular painkillers, involved in a series of serious illnesses and deaths.

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Breaking: Pharmacy First to launch end of January

The Pharmacist

The highly anticipated Pharmacy First common conditions service in England is set to launch at the end of January, it has been announced. The news comes as part of a series of announcements confirmed by NHS England (NHSE) and Community Pharmacy England (CPE) today, which also included updates on contraception and hypertension services. And CPE […] The post Breaking: Pharmacy First to launch end of January appeared first on The Pharmacist.

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STAT+: UnitedHealth faces class action lawsuit over algorithmic care denials in Medicare Advantage plans

STAT

A class action lawsuit was filed Tuesday against UnitedHealth Group and a subsidiary alleging that they are illegally using an algorithm to deny rehabilitation care to seriously ill patients, even though the companies know the algorithm has a high error rate. The class action suit, filed on behalf of deceased patients who had a UnitedHealthcare Medicare Advantage plan and their families by the California-based Clarkson Law Firm, follows the publication of a STAT investigation Tuesday.

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??A startling drop in U.S. life expectancy — and how pharma could help turn the tide

PharmaVoice

The recently observed dip was particularly acute for men, who now live an average of 5.8 fewer years than women.

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Long COVID study expanded across Europe

European Pharmaceutical Review

Biotech Berlin Cures, a company focusing on neutralising functional autoantibodies (fAABs), is expanding its Phase II clinical trial on Long COVID (post-COVID syndrome). into a pan-European, multi-center collaboration. The study will provide “meaningful and robust results on the efficacy and tolerability” of its lead drug candidate BC 007 in individuals with Long COVID.

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Why Every Small Business Needs an HCM Solution: A Comprehensive Guide

Managing HR tasks like payroll, compliance, and employee data can overwhelm small businesses. That’s where a Human Capital Management (HCM) solution comes in. Our eBook, Why Every Small Business Needs an HCM Solution: A Comprehensive Guide , shows how an HCM system automates tedious processes, ensuring your business stays compliant and efficient. You’ll learn how to simplify payroll, eliminate costly errors, and empower your employees with self-service tools.

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Shock of the old: 10 scandalous vintage medicines – from asthma cigarettes to cocaine wine

The Guardian - Pharmaceutical Industry

Cure any ailment! Never known to fail! Early medicine adverts made grand claims but they look alarming today The confusion with patent medicines starts with the name, since they were rarely ever patented; manufacturers just thought it sounded cool. Bamboozling was always part of the package: from the 17th century, concoctions of water, alcohol and herbs were sold with wild claims and exotic origin stories.

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Texas AG sues Pfiz­er and Tris Phar­ma for adul­ter­at­ed ADHD drug

Pharmaceutical Technology

Texas AG has sued Pfizer and Tris Pharma for providing adulterated attention-deficit/hyperactivity disorder drug, Quillivant XR, to children.

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Moderna adjusts to changing outlook for COVID vaccine demand

BioPharma Dive

The company recorded a net loss in the third quarter as it “resizes” its manufacturing footprint, and now expects revenue to come in at low end of its previous guidance.

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STAT+: UnitedHealth pushed employees to follow an algorithm to cut off Medicare patients’ rehab care

STAT

The nation’s largest health insurance company pressured its medical staff to cut off payments for seriously ill patients in lockstep with a computer algorithm’s calculations, denying rehabilitation care for older and disabled Americans as profits soared, a STAT investigation has found. UnitedHealth Group has repeatedly said its algorithm, which predicts how long patients will need to stay in rehab, is merely a guidepost for their recoveries.

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Best Practices to Streamline Compensation Management: A Foundation for Growth

Speaker: Joe Sharpe and James Carlson

Payroll optimization can be one of the most time-consuming and complex factors of small business management. Yet, organizations that crack the code on streamlining employee compensation often discover innovative avenues for growth. With the right strategies in place, outsourcing and streamlining payroll processes can result in substantial time and resource savings.

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Humans can’t shake the mosquito threat. Here’s what pharma has in the pipeline.

PharmaVoice

The arsenal against the world’s deadliest creature is growing and a universal vaccine is in the works.

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Pharmacists call for greater awareness following Question Time comment

The Pharmacist

Pharmacists have called for greater awareness of the profession after an MP appeared to mistakenly refer to the profession as ‘pharmacologists’ on BBC Question Time last night. Member of Parliament for Horsham and Cabinet Office minister Jeremy Quin highlighted the roles of ‘pharmacologists’ working in general practice in response to a comment made by a […] The post Pharmacists call for greater awareness following Question Time comment appeared first on The Pharmacist.

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FDA Approves CorMedix Inc’s Treatment for Bloodstream Infections in Patients Receiving Dialysis

PharmExec

Defencath is indicated for the prevention and treatment of catheter-related bloodstream infections in adults with kidney failure administered chronic hemodialysis via a central venous catheter.

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Innoviva and GARDP reveal positive results for antibiotic to treat gonorrhoea

Pharma Times

Zoliflodacin inhibits the vital bacterial enzyme for bacterial function and reproduction - News - PharmaTimes

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Roche’s Genentech partners with Nvidia in AI drug deal

BioPharma Dive

The partnership is another investment by the biotech subsidiary in artificial intelligence for drug discovery and development, continuing an industry trend.

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Life expectancy for men in U.S. falls to 73 years — six years less than for women, per study

STAT

The life expectancy of men in the U.S. is nearly six years shorter than that of women, according to new research published on Monday in JAMA Internal Medicine. At least partially as a consequence of over 1 million Covid-19 deaths, life expectancy in the U.S. has declined significantly over the past few years, falling from 78.8 years in 2019 to 77 in 2020 and 76.1 in 2022 — undoing over two decades of progress.

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Tools like ChatGPT can personalize clinical trials tech — if companies avoid the pitfalls

PharmaVoice

From hallucinations to data privacy, pharma looks to iron out the kinks of generative AI.

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Renewed call for national non-referral smoking cessation service

The Pharmacist

A fresh call has been made for a nationally commissioned non-referral smoking cessation service through community pharmacies, as the government announces major investment in local schemes. In the King’s Speech this week, it was revealed that the funding available to local smoking cessation services would ‘more than double’ by next April to £140m, while plans […] The post Renewed call for national non-referral smoking cessation service appeared first on The Pharmacist.

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Enhance Healthcare Efficiency With Top Payroll & HCM Services

Running a healthcare facility requires precision and care, not just for patients but also for your staff. Our guide, "A Buyer’s Guide to Payroll & HCM Services," helps healthcare providers choose the best provider. Efficient payroll management ensures timely, accurate payments, critical for maintaining staff morale and trust. Compliance support helps navigate complex healthcare regulations and avoid costly fines.

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FDA approves first therapy for rare type of non-cancerous tumors

World Pharma News

The U.S. Food and Drug Administration approved Ogsiveo (nirogacestat) tablets for adult patients with progressing desmoid tumors who require systemic treatment. Ogsiveo is the first drug to be approved for the treatment of patients with desmoid tumors, a rare subtype of soft tissue sarcomas.

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Milner Therapeutics to establish new genomics laboratory for drug discovery

Pharma Times

The new state-of-the-art facility is set to be operational in early 2024 - News - PharmaTimes

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FDA investigating cancer risk linked to CAR-T cell therapy

BioPharma Dive

The agency said the benefit of approved treatments like Gilead’s Yescarta still outweighs any such risk, but the alert could slow drugmaker efforts to develop the treatments for wider use.

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Study suggests Covid rebound is far more common with Paxlovid than without

STAT

A small and preliminary study published Monday seems to indicate that patients receiving the drug Paxlovid are far more likely to experience Covid rebound than those who did not take it. That conclusion runs counter to previous statements by Pfizer, which makes Paxlovid, and by researchers at the Food and Drug Administration who have argued that while it is not uncommon for people with Covid to have symptoms reemerge after they seem to have recovered, it is not clear that Paxlovid increases the

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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UK Authorizes World-First Gene Therapy from Vertex and CRISPR Therapeutics for Blood Disorders

Big Molecule Watch

Earlier today, UK’s Medicines and Healthcare products Regulatory Agency (MHRA) granted conditional marketing authorization to Vertex Pharmaceuticals and CRISPR Therapeutics for their CRISPR/Cas9 gene therapy, CASGEVY (exagamglogene autotemcel), marking the world’s first regulatory approval for a CRISPR-based gene-edited therapy. CASGEVY is the first medicine to be licensed that uses the innovative gene-editing tool CRISPR.

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Pharmacy inquiry will question NHSE chief exec

The Pharmacist

The chief executive of NHS England (NHSE), Amanda Pritchard, will be called before the Health and Social Care Committee’s (HSCC) pharmacy inquiry, which is expected to begin later this month. The inquiry is set to look at the Additional Roles Reimbursement Scheme (ARRS), workforce issues, proposed legislative changes to pharmacy supervision and hub and spoke […] The post Pharmacy inquiry will question NHSE chief exec appeared first on The Pharmacist.

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New Amgen immunotherapy could treat common solid tumour

European Pharmaceutical Review

Amgen’s new immunotherapeutic agent Tarlatamab has been shown in a Phase II trial to provide sustained anti-tumour activity in 40 percent of the small cell lung cancer patients. The international DeLLphi-301study was investigated as a new anti-cancer treatment option for patients previously considered to be beyond treatment. Results from the trial were published in the New England Journal of Medicine.

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Samay’s AI-assisted wearable technology accurately diagnoses COPD

Pharma Times

The device successfully diagnosed COPD in patients with 90% accuracy - News - PharmaTimes

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FDA names chief scientist Bumpus as Woodcock’s successor

BioPharma Dive

Bumpus, a former Johns Hopkins professor, named “creating a new model” for the FDA’s Office of Regulatory Affairs as one of her priorities when she steps into the role.

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