Thu.Dec 12, 2024

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STAT+: Prices for 5 drugs were hiked without proof of new benefits, costing the U.S. $815M in 2023, report finds

STAT

During 2023, drugmakers substantially raised prices on five widely used medicines without any new clinical evidence to justify the increases, leading patients and health insurers in the U.S. to spend an additional $815 million last year, according to a new report. The drug for which spending increased the most due to a price increase was Biktarvy, which is prescribed to treat HIV and is a franchise product for Gilead Sciences.

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Under-18s puberty blocker ban extended indefinitely following expert advice

The Pharmacist

The UK ban on private prescribing of puberty blockers in under-18s with gender dysphoria has been extended indefinitely, the government has announced. It follows a consultation on the measures and independent advice from the Commission on Human Medicines (CHM) which found an unacceptable safety risk in the continued prescription of puberty blockers to children.

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Trending Sources

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STAT+: Pharmalittle: We’re reading about unsupported drug price hikes, an annual HIV prevention shot, and more

STAT

Top of the morning to you, and a fine one it is. Clear blue skies and chilly breezes are wafting across the Pharmalot campus, where the official mascots are snoozing after foraging for their breakfast. This means we are free to focus on the matters at hand — rummaging through our to-do list and making cups of stimulation. Our choice today is maple cinnamon French toast.

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How to Identify Branded Drugs with a Low Likelihood of Generic Entry as Targets for In-Licensing

Drug Patent Watch

Identifying branded drugs with a low likelihood of generic entry has become a crucial strategy for companies looking to expand their product portfolio through in-licensing. This approach not only helps maintain market exclusivity but also ensures a steady revenue stream for pharmaceutical companies. In this comprehensive guide, we’ll explore the intricacies of identifying such drugs and leveraging them for successful in-licensing opportunities.

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Navigating Payroll Compliance: Future-Proofing Payroll in an Evolving Regulatory Landscape

Speaker: Jennifer Hill

Payroll compliance is a cornerstone of business success, yet for small and midsize businesses, it’s becoming increasingly challenging to navigate the ever-evolving landscape of federal, state, and local regulations. Mistakes can lead to costly penalties and operational disruptions, making it essential to adopt advanced solutions that ensure accuracy and efficiency.

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STAT+: AI versus AI: The emerging arms race over health insurance denials

STAT

Like many Americans, Holden Karau said she was fed up with health insurance. The software engineer’s disillusionment began in 2019, when her insurer, UnitedHealthcare, balked at covering physical therapy after she was hit by a car and could not walk. She said the hassles piled on stress, forced her to pay more out of pocket, and delayed access to care she needed to recover from multiple broken bones.

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CDC finds no evidence of bird flu virus in California toddler

STAT

Testing of samples taken from a child in California thought to have contracted H5N1 bird flu after drinking raw milk turned up no evidence of influenza viruses, the Centers for Disease Control and Prevention said Thursday.  A test run on a sample from the child — who went to a Marin County emergency department last week with a fever and vomiting — had been positive there for flu A.

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Leriglitazone meets primary endpoint in pivotal cALD trial

Pharma Times

Promising trial results support marketing authorisation application

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STAT+: Editas Medicine lays off 65% of staff and shelves lead gene-editing program

STAT

Editas Medicine said Thursday afternoon it will lay off 65% of its staff — around 180 employees — as it shelves its lead gene-editing program for sickle cell disease and shifts focus.  The cuts come amid a prolonged financial downturn for the gene-editing field, as valuations have plummeted and layoffs have become widespread. Editas already laid off staff as part of a restructuring in 2023.

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Pharmacy First antibiotic rates show pharmacists acting responsibly, says CCA

The Pharmacist

New Pharmacy First analysis has suggested pharmacists are treating antimicrobial stewardship with utmost importance and only supplying antibiotics when appropriate. On average, two-thirds (66%) of patients attending pharmacies for earaches, bladder infections, sore throats, sinusitis, infected insect bites or impetigo are provided antibiotics, according to a new report by the Company Chemists Association (CCA).

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Opinion: What I’ve learned — the hard way — about AI in bio

STAT

As we approach the end of 2024, First Opinion is publishing a series of essays on the state of AI in medicine and biopharma.  There’s more to life than protein folding.

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Bayer begins inhibitor study treating advanced KRAS-mutated tumours

Pharma Times

Trial explores potential of therapy in treating multiple cancer types

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STAT+: Arcellx won the battle of BCMA CAR-T therapies

STAT

This story first appeared in Adam’s Biotech Scorecard, a subscriber-only newsletter. STAT+ subscribers can sign up  here  to get it delivered to their inbox. I just returned from San Diego and the annual meeting of the American Society of Hematology, where Arcellx won the battle of BCMA CAR-T therapies against Legend Biotech. Legend has downplayed the significance of the 12-17% rate of delayed neurotoxicity — Parkinsonian symptoms and cranial nerve palsies — report

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Nobel laureates ‘strongly urge’ Senate to oppose confirmation of RFK Jr

Pharmaceutical Technology

In the letter, 77 Nobel Prize winners argue that appointing RFK as Secretary of HHS would put the US publics health in jeopardy.

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Why Every Small Business Needs an HCM Solution: A Comprehensive Guide

Managing HR tasks like payroll, compliance, and employee data can overwhelm small businesses. That’s where a Human Capital Management (HCM) solution comes in. Our eBook, Why Every Small Business Needs an HCM Solution: A Comprehensive Guide , shows how an HCM system automates tedious processes, ensuring your business stays compliant and efficient. You’ll learn how to simplify payroll, eliminate costly errors, and empower your employees with self-service tools.

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Opinion: In a threat to patient trust, Texas hospitals must ask ‘Are you a U.S. citizen?’

STAT

As a first-generation immigrant, much of my childhood was spent in a state of perpetual uncertainty. My family and I fixated on an ever-refreshing screen, patiently watching our status shift from “H-1B visa” to “green card” holder to “citizen” over 14 long years. Yet amid this endless cycle of anxiety, one place surprisingly gave me solace: the hospital.

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UK indefinitely bans puberty blockers for teenagers due to “unacceptable risk”

Pharmaceutical Technology

Puberty blockers for people aged under 18 with gender dysphoria will be indefinitely banned by the UK Government.

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When AI becomes a tool to fight insurance denials

STAT

You’re reading the web edition of STAT’s Health Tech newsletter, our guide to how technology is transforming the life sciences.  Sign up to get it  delivered in your inbox every Tuesday and Thursday. Companies use AI to fight insurance denials People infrequently challenge health insurance denials even though appeals are often successful.

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Sanofi’s combo vaccines gain FDA fast track designation

Pharmaceutical Technology

Sanofi has announced that its two combination vaccine candidates have received fast track status from the US FDA.

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Best Practices to Streamline Compensation Management: A Foundation for Growth

Speaker: Joe Sharpe and James Carlson

Payroll optimization can be one of the most time-consuming and complex factors of small business management. Yet, organizations that crack the code on streamlining employee compensation often discover innovative avenues for growth. With the right strategies in place, outsourcing and streamlining payroll processes can result in substantial time and resource savings.

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The biotech news you need to read today

STAT

Want to stay on top of the science and politics driving biotech today?  Sign up  to get our biotech newsletter in your inbox. Good morning, let’s get straight into the news today.

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Deep Science Ventures and General Inception collaborate to create fibrosis-focused therapeutics company

Pharmafile

12 December 2024 London, UK, and Palo Alto, CA, US Deep Science Ventures, a UK-based venture studio, and General Inception, a US-based venture studio, today announced a collaboration to create a company focused on developing novel treatments for fibrosis. Widely recognised as an area of significant unmet need, Deep Science Ventures and General […] The post Deep Science Ventures and General Inception collaborate to create fibrosis-focused therapeutics company appeared first on Pharmafile.

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Regeneron’s R&D approach scores dual wins against Alexion’s Ultomiris and in lymphoma

PharmaVoice

At this year’s ASH conference, Regeneron posted results for treatments that could disrupt the standards of care in two blood-related diseases.

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Flu vaccine strategy on the line as new US leaders anticipated to take charge

Pharmaceutical Technology

Public health experts are anticipating a changing discourse following RFK Jrs appointment as head of HHS.

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Enhance Healthcare Efficiency With Top Payroll & HCM Services

Running a healthcare facility requires precision and care, not just for patients but also for your staff. Our guide, "A Buyer’s Guide to Payroll & HCM Services," helps healthcare providers choose the best provider. Efficient payroll management ensures timely, accurate payments, critical for maintaining staff morale and trust. Compliance support helps navigate complex healthcare regulations and avoid costly fines.

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Targeting ovarian cancer with a novel antibody therapeutic

European Pharmaceutical Review

What is Elahere (mirvetuximab soravtansine) and what makes it unique as a medicine for ovarian cancer? Elahere is the first and only novel therapy approved in the EU for patients with folate receptor alpha (FR)-positive, platinum-resistant ovarian cancer (PROC).This treatment is an FR-directed antibody drug conjugate (ADC) that targets FR, a cellular membrane protein, delivering a cancer killing drug directly into the cancer cells, sparing healthy tissue.

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Understanding Adrenal Fatigue

Compounding Pharmacy of America

Discover the symptoms, causes, and natural treatments for adrenal fatigue. Learn how tools like the Adrenal Stress Test Kit and targeted supplements can restore balance and energy. The post Understanding Adrenal Fatigue appeared first on Compounding Pharmacy of America.

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How to Evaluate CDMO Performance: Key Considerations and Best Practices

Drug Patent Watch

The pharmaceutical industry relies heavily on Contract Development and Manufacturing Organizations (CDMOs) to outsource various stages of drug development and manufacturing. With the increasing complexity of drug development and the need for efficient, cost-effective solutions, selecting the right CDMO is crucial. Evaluating CDMO performance is a critical step in this process, ensuring that the chosen partner can meet the required standards and deliver high-quality products.

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East Ocyon Bio closes $4.2M Seed round led by Aeravti Ventures and Micro Labs

Express Pharma

East Ocyon Bio, an allogeneic Cell and Gene Therapy (CGT) startup announced the closure of its $4.2 million Seed round. The investment round was led by Aeravti Ventures and Micro Labs. The newly raised funds will be utilised to enable several key initiatives like pre-clinical testing of CAR-NK and CAR-gamma delta T cell therapies, the creation of a GMP manufacturing facility, and Phase I clinical trials.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Investing in This Idea Can Foster Employee Engagement

The Script

Searching for ways to foster employee engagement & boost overall morale in your workplace? Our team at Rx relief weighs in.

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BREAKING: GPhC plans to ‘update’ pharmacy inspections in January

The Pharmacist

The General Pharmaceutical Council (GPhC) has announced plans to update and improve the way it inspects pharmacies. It has outlined a set of proposals to its governing council which include the introduction of shorter, more focused inspections, alongside its full inspections. Under the plans, inspectors will have the option to switch to a full inspection […] The post BREAKING: GPhC plans to update pharmacy inspections in January appeared first on The Pharmacist.

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Noema Pharma raises $147 million to develop drugs for neurological conditions

Outsourcing Pharma

Noema Pharma extends its series B funding to $147M, advancing phase 2 trials for CNS disorders like Tourette syndrome, menopause symptoms, and neuropathic pain.

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