Fri.Feb 16, 2024

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STAT+: In ‘major milestone,’ FDA approves first cell therapy for solid tumors

STAT

Nearly four decades after its first conception, the first TIL therapy, an immunotherapy that harvests cancer-fighting immune cells from the patient’s own body, received accelerated approval from the Food and Drug Administration for advanced melanoma. The therapy, called Amtagvi or lifileucel from Iovance, is the first cell therapy approved for a solid tumor.

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SAEM Clinical Images Series: An Ultrasonographic Rabbit Hole

ALiEM - Pharm Pearls

An 86-year-old man with a past medical history of coronary artery disease, hypertension, hyperlipidemia, chronic kidney disease, COPD, choledocholithiasis requiring ERCP and sphincterotomy 2 years ago presented with five days of feeling unwell. History was limited due to cognitive impairment. His daughter had reported to staff he had been feeling unwell for five days, intermittently having nausea and generalized abdominal pain, subjective fevers, chest pain, and shortness of breath.

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Solving astronauts’ health challenges in deep space could have payoffs on Earth

STAT

Space is famously known as the final frontier for human exploration. It may also be the final frontier for human medicine. That’s what Dorit Donoviel, executive director of the Translational Research Institute for Space Health, and her team are working towards. TRISH is a consortium between Baylor College of Medicine, Caltech, and the Massachusetts Institute of Technology that partners with NASA to solve the health challenges of humans exploring deep space.

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Pharma CFOs need vigilance in tough economic times

PharmaVoice

Belt tightening and streamlined portfolios are critical in 2024 amid continued economic uncertainty.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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STAT+: Medicare Advantage enrollment races past 33 million

STAT

Roughly 33.4 million adults older than 65 and people with disabilities were enrolled in a Medicare Advantage plan as the calendar flipped to 2024 — another year of steady, albeit slower, growth for the taxpayer-funded program. Enrollment increased 7.1% year over year, which would make this year’s annual growth rate identical to last year’s , according to new federal Medicare Advantage enrollment data analyzed by STAT.

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Mounjaro weight loss service hoped to ease supply issues

The Pharmacist

Hundreds of community pharmacies have begun offering a tirzepatide injection as part of a new weight loss service beginning this week. The move follows the approval of a new four-dose version of Mounjaro last month. It is hoped that the new service will expand the availability of private weight-loss treatments amid ongoing shortages of alternatives […] The post Mounjaro weight loss service hoped to ease supply issues appeared first on The Pharmacist.

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Study backs safety of Gilead CAR-T as outpatient therapy

pharmaphorum

CAR-T therapies can achieve remarkable efficacy in the treatment of haematological cancers, but the risk of side effects means that the cell infusions are almost always administered to inpatients under close supervision in clinics.

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STAT+: Flagship Pioneering startup lays off a third of staff

STAT

Sonata Therapeutics, a startup created two years ago through the merger of two Flagship Pioneering companies, has laid off about a third of its staff. The biotech laid off 21 employees in recent weeks, according to employee posts on social media and a company spokesperson. Sonata had around 63 employees before the layoffs. Sonata is just the latest in a series of startups laying off employees in order to stretch out their cash runways.

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Freenome raises $254m for cancer tests, and other financings

pharmaphorum

Recent biotech financings include a $245m raise for cancer blood test company Freenome, plus big rounds for Cogent Biosciences, BioAge Labs, Latigo Biotherapeutics, ProfoundBio, and Firefly Bio

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STAT+: Louisiana, Oregon deals show health insurer acquisitions aren’t a sure thing anymore

STAT

A deal is never really done until it’s done. On Tuesday, two different proposed insurance plan acquisitions on different sides of the country called it quits — one of them for the second time. California-based Medicare Advantage insurer SCAN Group has been trying to buy CareOregon, an insurer offering coverage to half a million people in Oregon’s state health plan, since January 2023.

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Why Every Small Business Needs an HCM Solution: A Comprehensive Guide

Managing HR tasks like payroll, compliance, and employee data can overwhelm small businesses. That’s where a Human Capital Management (HCM) solution comes in. Our eBook, Why Every Small Business Needs an HCM Solution: A Comprehensive Guide , shows how an HCM system automates tedious processes, ensuring your business stays compliant and efficient. You’ll learn how to simplify payroll, eliminate costly errors, and empower your employees with self-service tools.

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Blockchain For Impact announces USD 15 million fund for biomedical research and innovation in India

Express Pharma

As part of the collaboration with IISc, BFI-Biome Network will allocate up to $1 million over three years to drive its Translational Research Projects ranging from TRL 2-4 Blockchain for Impact, the philanthropy initiative by Sandeep Nailwal, has announced a $15 million fund dedicated to advancing biomedical research and innovation in India, under the BFI-Biome Virtual network.

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STAT+: Bipartisan group of lawmakers warns of a rising Chinese threat to U.S. biotech

STAT

CAMBRIDGE, Mass. — The increasingly adversarial relationship between the United States and China has raised national security concerns about Chinese penetration into key sectors of the U.S. economy, such as technology, manufacturing, and clean energy. Now, some in Congress are raising alarms about China’s threat to another vital industry: biotechnology.

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Gilead’s CD47 woes continue, this time in solid tumours

pharmaphorum

Gilead Sciences has paused enrolment in clinical trials of its CD47 drug magrolimab in solid tumours, a week after dropping it for blood cancers.

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Alnylam thickened the plot

STAT

Want to stay on top of the science and politics driving biotech today?  Sign up  to get our biotech newsletter in your inbox. Hello, everyone. Damian here with a look at pharma’s struggle to make inroads in D.C., the curious story of the latest FDA drug approval, and a twist on the year’s biggest biotech event. One more thing: We’ll be taking off Monday for Presidents’ Day, but this newsletter will be back in your inbox bright and early Tuesday morning.

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Best Practices to Streamline Compensation Management: A Foundation for Growth

Speaker: Joe Sharpe and James Carlson

Payroll optimization can be one of the most time-consuming and complex factors of small business management. Yet, organizations that crack the code on streamlining employee compensation often discover innovative avenues for growth. With the right strategies in place, outsourcing and streamlining payroll processes can result in substantial time and resource savings.

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ALS drug from Denali, Sanofi falls short in mid-stage study

BioPharma Dive

The disclosure the experimental therapy missed its trial goal comes after Sanofi had earmarked the drug for advancement into Phase 3.

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STAT+: Up and down the ladder: The latest comings and goings

STAT

Hired someone new and exciting? Promoted a rising star? Finally solved that hard-to-fill spot? Share the news with us, and we’ll share it with others. That’s right. Send us your changes, and we’ll find a home for them. Don’t be shy. Everyone wants to know who is coming and going. And here is our regular feature in which we highlight a different person each week.

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Astellas pledges $800m to Kelonia CAR-T alliance in cancer

pharmaphorum

Astellas has signed a deal with Kelonia Therapeutics that aims to push the boundaries of what can be achieved with CAR-T therapies in immuno-oncology

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Overcoming challenges of continuous antibody manufacture

European Pharmaceutical Review

Researchers have highlighted the potential of end-to-end continuous manufacture with column-free capture alternatives. The traditional batch process was compared with end-to-end continuous bioprocesses with either protein A (ProA) capture or column-free capture, employing aqueous two-phase extraction (ATPE) or precipitation from economic, environmental, and robustness perspectives.

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Enhance Healthcare Efficiency With Top Payroll & HCM Services

Running a healthcare facility requires precision and care, not just for patients but also for your staff. Our guide, "A Buyer’s Guide to Payroll & HCM Services," helps healthcare providers choose the best provider. Efficient payroll management ensures timely, accurate payments, critical for maintaining staff morale and trust. Compliance support helps navigate complex healthcare regulations and avoid costly fines.

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Industry can support clinicians with prescribing decisions

pharmaphorum

The ABPI has released a new guide on how the industry can support clinicians with prescribing decisions. Find out more about how pharmaceutical companies can assist healthcare professionals in providing optimal patient care.

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Astellas teams up with startup Kelonia to make ‘in vivo’ cell therapies

BioPharma Dive

Kelonia will receive $40 million upfront through a partnership to develop “off-the-shelf” cell therapies for cancer.

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Patentability and predictability in AI-assisted drug discovery

pharmaphorum

Explore the role of artificial intelligence and machine learning in drug discovery and the challenges associated with patentability and predictability. Learn how AI is revolutionising the pharmaceutical industry.

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The Phasing out of Copper Wire Landline Service & the Impact on Pharmacy Communication

Digital Pharmacist

In an age where technology is advancing at an exponential rate, it’s no surprise that traditional methods of communication are gradually being phased out. One such example is the shift away from copper wire landline services, a move that has been gaining momentum across various regions in the United States. This transition signifies a significant shift towards a more modern and efficient telecommunications infrastructure, but as with any change, is sure to be accompanied by some challenges

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Patterns of behaviour: Using AI-based algorithms to improve outcomes for patients with atrial fibrillation

pharmaphorum

Patterns of behaviour: Using AI-based algorithms to improve outcomes for patients with atrial fibrillation Mike.

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Otsuka wins FDA breakthrough therapy designation for IgAN drug 

Pharmaceutical Technology

This positive news comes after Otsuka’s Phase III Alzheimer’s agitation trial failed to meet its primary endpoint, announced earlier this week.

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JP Morgan 2024 – Xavier Duportet

pharmaphorum

In this interview, Jonah Comstock speaks with Xavier Duportet, the founder and CEO of the biotech company, Eligo Bioscience, about the future of CRISPR gene editing at JP Morgan in 2024. Dive into the discussion to gain insights into this cutting-edge technology and its potential impact on the healthcare industry.

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Researchers investigate new technique for diagnosing cardiac conditions

Pharma Times

Cardiac quantitative susceptibility mapping successfully visualised iron deposits in patients

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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Paul Rees: ‘We need a new deal for pharmacy’

The Pharmacist

EXCLUSIVE Community pharmacy needs a ‘new deal’ that considers estates costs, training time and does not force pharmacies to dispense at a loss, the recently appointed National Pharmacy Association (NPA) chief executive has told The Pharmacist. In his first interview with The Pharmacist since his appointment in November, Paul Rees spoke about his experience working […] The post Paul Rees: ‘We need a new deal for pharmacy’ appeared first on The Pharmacist.

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GSK concludes Aiolos Bio acquisition for $1.4bn

Pharmaceutical Technology

GSK has successfully concluded the acquisition of Aiolos Bio in a deal that could reach $1.4bn, expanding its respiratory portfolio.

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The Drug Discount Ecosystem Needs Clarity in 2024 and Beyond

Drug Channels

Today’s guest post comes from Gavin Magaha, Senior Director of Value Delivery at Kalderos. Gavin discusses the problems manufacturers face in accessing and standardizing drug discount data. These data are necessary to avoid duplicate discounts and comply with regulatory requirements. To learn more about how the Inflation Reduction Act adds to challenges of drug discount programs, download Kalderos’ whitepaper: Operational Complexity and Evolving Challenges: What Drug Manufacturers Need to Know N

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Neurona secures $120m to advance lead cell therapy candidate for epilepsy

Pharma Times

NRTX-1001 is being assessed for drug-resistant mesial temporal lobe epilepsy

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DHL Supply Chain Invests $200M Toward Expanding its Life Sciences and Healthcare Services

Pharmaceutical Commerce

The financial commitment features construction of new warehouses in Pennsylvania and North Carolina.

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