Mon.Apr 14, 2025

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Closure of CDC hepatitis lab imperils U.S. outbreak response, prevention

STAT

An estimated 4 million Americans are infected with hepatitis C, a disease that can go undetected for years. Another 2.4 million people in this country are chronically infected with hepatitis B, which is the leading cause of liver cancer globally. Hepatitis B is preventable, and hepatitis C is curable. But the U.S. capacity to battle these viral scourges has been leveled a devastating blow with the April 1 closure of the country’s premier testing laboratory for viral hepatitis, experts war

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Remegen eyes competitive DMT market as telitacicept shows promise in gMG: GlobalData

Express Pharma

At the recently held 2025 American Academy of Neurology (AAN) meeting, Remegen presented positive Phase III results for telitacicept in patients with AChR+ or MuSK+ generalised myasthenia gravis (gMG). The B cell-targeting therapy demonstrated a favorable efficacy and safety profile over 24 weeks, showing clinically meaningful improvement. These findings position telitacicept as a potential challenger to the existing disease-modifying therapies (DMTs), says GlobalData.

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Trending Sources

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STAT+: Verve gene-editing therapy lowers cholesterol without serious side effects in early study

STAT

Verve Therapeutics said initial data show that its investigational gene-editing therapy lowered cholesterol without inducing serious side effects, a positive step for the company after it paused development of an earlier treatment due to safety concerns. The early data from an ongoing Phase 1 study show that a single infusion of the therapy, called Verve-102, led to greater decreases in “bad” LDL cholesterol with higher doses, according to an announcement Monday.

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Pharma’s capital allocation could shift as tariffs threaten an already fragile profit model

PharmaVoice

Major changes to the dynamics of the pharmaceutical ecosystem are making executive decisions even tougher.

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Navigating Payroll Compliance: Future-Proofing Payroll in an Evolving Regulatory Landscape

Speaker: Jennifer Hill

Payroll compliance is a cornerstone of business success, yet for small and midsize businesses, it’s becoming increasingly challenging to navigate the ever-evolving landscape of federal, state, and local regulations. Mistakes can lead to costly penalties and operational disruptions, making it essential to adopt advanced solutions that ensure accuracy and efficiency.

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STAT+: Pfizer to discontinue its GLP-1 pill for obesity due to liver toxicity

STAT

Capping more than two years of stock-gyrating drama, Pfizer said Monday that it would stop development of danuglipron, its experimental oral GLP-1 medicine to treat obesity, focusing its efforts on another medicine with a different mechanism of action. Pfizer said in a press release that an asymptomatic volunteer in the company’s studies experienced “potential drug-induced liver injury,” which resolved after stopping the medication.

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Tech modernization at community health centers in limbo after federal workforce cuts

STAT

The future of a technology modernization program, meant to help the government understand if the billions of tax dollars it spends on community health centers are in fact making Americans healthy, now looks uncertain. The layoffs at the Department of Health and Human Services included dozens of employees at the Health Resources and Services Administration who were working on the technology upgrade, which has been years in the making and was set to launch next month.

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North West pharmacies invited to apply for RSV and pertussis vaccine service

The Pharmacist

Some 66 pharmacies in the North West can now apply to deliver the respiratory syncytial virus (RSV) and pertussis (whooping cough) vaccine, under a new NHS England invitation to tender. It follows an earlier tender of the service in the Midlands region, which closed last month. The North West tender, published last week, sets out […] The post North West pharmacies invited to apply for RSV and pertussis vaccine service appeared first on The Pharmacist.

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STAT+: Attorneys general want Congress to prohibit PBMs from owning affiliated pharmacies

STAT

Dozens of state attorneys general are urging Congress to pass a law prohibiting pharmacy benefit managers from simultaneously owning pharmacies, arguing such a move would boost competition and create more affordable prescription drug prices for Americans. Their concern is these arrangements create conflicts of interest that allow pharmacy benefits managers to dominate the design of health plans for tens of millions of Americans, and also distort the distribution and pricing for prescription medi

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How to Ensure Compliance in Generic Drug Development

Drug Patent Watch

"Compliance in Generic Drug Development: A Critical Component of Success As the generic drug industry continues to grow, ensuring compliance with regulatory requirements has become a top priority for pharmaceutical companies. At DrugPatentWatch, we've seen firsthand the importance of staying on top of regulatory changes and maintaining a robust compliance program.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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STAT+: Canada advances an antitrust probe into Express Scripts over ‘patient steering’ and pharmacy fees

STAT

Canadian officials have obtained a court order that requires Express Scripts to produce documents in connection with an investigation into whether the pharmacy benefits manager violated antitrust laws. The Competition Bureau is examining whether the company forced or induced Canadians to use its own pharmacies. Express Scripts operates four mail-order pharmacies across the country, except in Quebec.

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Innovative approach could improve cancer immunotherapy

European Pharmaceutical Review

New research has proposed a method to increase the effectiveness of tumour-infiltrating lymphocyte (TIL) immunotherapy. Investigators identified that the natural immune protein called CD40L was key in improving TIL cultures in the lab. We discovered that by adding CD40L to the immune cells in the lab, we could dramatically improve the number and quality of cancer-fighting T cells were able to grow, explained Daniel Abate-Daga, PhD, lead author of the study and Scientific Director of the Cell The

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Opinion: STAT+: Biotech investors: Stop expecting CRISPR science to make big leaps

STAT

The medical promise of CRISPR gene editing can be seen most easily in current research on oral cancer, which affects more than 50,000 Americans every year. An increasing challenge in the treatment of oral cancer is that tumors become resistant to chemotherapy. By injecting CRISPR gene editing directly in the tumors and targeting the genetic resistance to common chemotherapy agents, we could potentially enable that standard of care for cancer to work once again for patients, overcoming one of the

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PDA unveils ‘six-step test’ for community pharmacy funding

The Pharmacist

The Pharmacists Defence Association (PDA) has produced six steps to pressure test any future pharmacy funding arrangements. The union stressed that the contractual framework for the sector must go beyond financial negotiations and prioritise the practical realities of community pharmacy. It comes after news of a 3.073bn Community Pharmacy Contractual Framework (CPCF) has been agreed […] The post PDA unveils six-step test for community pharmacy funding appeared first on The Pharmacist.

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Why Every Small Business Needs an HCM Solution: A Comprehensive Guide

Managing HR tasks like payroll, compliance, and employee data can overwhelm small businesses. That’s where a Human Capital Management (HCM) solution comes in. Our eBook, Why Every Small Business Needs an HCM Solution: A Comprehensive Guide , shows how an HCM system automates tedious processes, ensuring your business stays compliant and efficient. You’ll learn how to simplify payroll, eliminate costly errors, and empower your employees with self-service tools.

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Autism and the gut-brain connection

STAT

Get your daily dose of health and medicine every weekday with STAT’s free newsletter Morning Rounds.  Sign up here. Good morning. For those who were curious, our turkey friend at STAT headquarters last week was indeed a wild turkey, not a turkey vulture. A number of images from different angles, checked with multiple amateur ornithologists, all made our neighbor’s species clear.

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Survey suggests Britons with a disability are concerned over AI-integrated healthcare

Pharmafile

A survey conducted by nuom, a British healthcare consultancy, found a majority of UK adults with a disability are concerned that artificial intelligence (AI)-integrated healthcare could prioritise efficiency over inclusivity. Nuom emphasises the need for inclusive technologies that are developed with those with disabilities as AI in healthcare continues to develop.

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STAT+: Pharmalittle: We’re reading about Pfizer halting GLP-1 work, FDA use of contractors, and more

STAT

Good morning, everyone, and welcome to another working week. We hope the weekend respite was relaxing and refreshing because, once again, that predictable routine of meetings, deadlines, and the like has returned. After all, the world keeps spinning. And to cope, yes, we are relying on cups of stimulation to help us along. Our choice today is pumpkin spice.

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NHC Submits Comments on CMS’ Proposed Rule on Marketplace Integrity and Affordability

Putting Patients First Blog

NHC Submits Comments on CMS Proposed Rule on Marketplace Integrity and Affordability (PDF) April 11, 2025 Mehmet Oz, MD, MBA Administrator Centers for Medicare & Medicaid Services Department of Health and Human Services 7500 Security Boulevard Baltimore, MD 21244 RE: Patient Protection and Affordable Care Act; Marketplace Integrity and Affordability [CMS-9884-P] Dear Administrator Oz, The National Health Council (NHC) appreciates the opportunity to provide comments on the Centers for Medica

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Best Practices to Streamline Compensation Management: A Foundation for Growth

Speaker: Joe Sharpe and James Carlson

Payroll optimization can be one of the most time-consuming and complex factors of small business management. Yet, organizations that crack the code on streamlining employee compensation often discover innovative avenues for growth. With the right strategies in place, outsourcing and streamlining payroll processes can result in substantial time and resource savings.

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Pfizer discontinues its experimental GLP-1 pill

STAT

Want to stay on top of the science and politics driving biotech today?  Sign up  to get our biotech newsletter in your inbox. Morning. Today, we discuss interesting new gene-editing data from Verve, see the NIH starting to convene advisory councils again, and more.

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Nordic Pharma’s Lacrifill canalicular gel gains CE mark approval and set for European launch

Pharmafile

International pharma company Nordic Pharma has announced that its Lacrifill treatment for dry eye disease has received European Conformity (CE) mark approval. This will allow the company to introduce the product across European markets within a few months and expand its global footprint. Lacrifill is a novel treatment which keeps eyes bathed in their own […] The post Nordic Pharmas Lacrifill canalicular gel gains CE mark approval and set for European launch appeared first on Pharmafile.

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Nona Biosciences and Atossa team up to discover breast cancer therapies

Pharmaceutical Business Review

The partnership will leverage Nonas two heavy and two light chain (H2L2) Harbour Mice platforms to detect next-generation therapeutic candidates. The platform employs transgenic mice to produce fully human monoclonal antibodies in H2L2 format and the heavy chain-only (HCAb) format. This approach is said to eliminate the need for further engineering or humanisation of the antibodies.

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US launches probe that could set stage for pharma tariffs

BioPharma Dive

The Commerce Department has begun a so-called Section 232 investigation into the national security effects of the U.S. importing pharmaceuticals and their starting materials.

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Enhance Healthcare Efficiency With Top Payroll & HCM Services

Running a healthcare facility requires precision and care, not just for patients but also for your staff. Our guide, "A Buyer’s Guide to Payroll & HCM Services," helps healthcare providers choose the best provider. Efficient payroll management ensures timely, accurate payments, critical for maintaining staff morale and trust. Compliance support helps navigate complex healthcare regulations and avoid costly fines.

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Epocrates

RX Note

Introduction Historically, Epocrates is the first medical application on Apple's App Store. When the iPhone was just about 8 months old, a California neurologist started a petition to get epocrates onto the iPhone. Almost 500 doctors signed and that's when Steve Jobs invited epocrates developers to develop one of the first Software Development Kits for the iPhone.

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New test prototype for monitoring MGUS patients funded

Pharma Times

Birmingham researchers to make MGUS monitoring more efficient

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Kyowa Kirin constructs drug manufacturing facility in Japan

Pharmaceutical Technology

Kyowa Kirin has concluded the construction of its new drug substance (DS) manufacturing facility, the HB7 building in Japan.

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Approval moves Columvi earlier in DLBCL treatment pathway

pharmaphorum

Roche has claimed a first-in-class approval in the EU for Columvi in relapsed/refractory diffuse large B-cell lymphoma (DLBCL).

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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UK clinical trials regulations signed into law

Pharma Times

Major update aims to accelerate research and strengthen patient safety

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1:1 Nursing Podcast – Episode 0 – The Introduction

EMCrit Project

Intro to the 1:1 Nursing Podcast EMCrit Project by Scott Weingart, MD FCCM.

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BMS gets another FDA okay for Opdivo/Yervoy combo

pharmaphorum

Bristol-Myers Squibb has claimed its second FDA approval in just a few days for its Opdivo/Yervoy combination, this time in liver cancer.

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