Thu.Aug 01, 2024

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Behind the malaria vaccines: A 40-year quest against one of humanity’s biggest killers

STAT

Malaria is one of our most ancient foes — and one of the wiliest. Caused by parasites that certain mosquitoes spread through their bites, malaria overwhelms us, establishing an infection before we can put up a fight. It can go on to destroy red blood cells, batter organs, and even damage the brain.

Vaccines 363
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Read to lead: 6 books pharma execs swear by

PharmaVoice

From an epic, alternative reality fantasy to a ‘biography of cancer,’ these six reads have stuck with pharma execs as they navigate how to lead.

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STAT+: Eli Lilly’s obesity drug Zepbound shows benefits in heart failure patients

STAT

Eli Lilly’s obesity drug Zepbound cut the risk of complications and improved symptoms in patients with a common type of heart failure, making it the second GLP-1 drug to show positive results in the disease area after Novo Nordisk’s Wegovy. The Phase 3 trial studied patients who had heart failure with preserved ejection fraction (or HFpEF) and obesity.

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Pfizer’s Bourla confident in company’s obesity drug position, despite delays

PharmaVoice

The CEO noted how Pfizer's danuglipron could still be the second oral GLP-1 treatment to enter registrational tests after Lilly's orforglipron.

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Why Every Small Business Needs an HCM Solution: A Comprehensive Guide

Managing HR tasks like payroll, compliance, and employee data can overwhelm small businesses. That’s where a Human Capital Management (HCM) solution comes in. Our eBook, Why Every Small Business Needs an HCM Solution: A Comprehensive Guide , shows how an HCM system automates tedious processes, ensuring your business stays compliant and efficient. You’ll learn how to simplify payroll, eliminate costly errors, and empower your employees with self-service tools.

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Morning Rounds: Inside the making of the first malaria vaccine

STAT

Want to stay on top of health news?  Sign up  to get our Morning Rounds newsletter in your inbox. Okay, I know it’s unoriginal to express awe at the speed at which time passes, but like … how is it already August? Okay, instead I will recall Louise Glück’s “ Matins.” (“You want to know how I spend my time?

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Lilly obesity drug shows heart benefit in late-stage trial

BioPharma Dive

The drug led to a 38% reduction in the risk of death or complications from a type of heart failure, a finding that compared favorably to available treatments.

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More Trending

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Moderna shares fall amid lower sales outlook for RSV, COVID shots

BioPharma Dive

The biotech cited competitive pressure and “very low” expected sales in Europe for its latest guidance cut, which sent shares down by nearly 20%.

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STAT+: With new data, Regenxbio advances plan for Duchenne gene therapy

STAT

Regenxbio said Thursday that its experimental gene therapy for Duchenne muscular dystrophy was administered to two more boys and produced high levels of a miniaturized version of the protein needed for muscles to function properly. The updated results from an early study suggest the Regenxbio therapy, called RGX-202, could become the second genetic medicine for Duchenne to reach the market, following the Food and Drug Administration’s approval of Sarepta Therapeutics’ Elevidys in J

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Changing Faces: May and June 2024 supplier and digital hires

pharmaphorum

Changing Faces announces new supplier and digital hires for May and June 2024, including AxoSim, ERS Genomics, Newcells Biotech, SHINE Technologies and more. Stay updated with the latest industry developments.

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4 takeaways from STAT’s story on the development of malaria vaccines

STAT

For the first time, the world is starting to roll out malaria vaccines to children in sub-Saharan Africa. The story of the development of those vaccines, a decades-long effort that stretched from labs in New York, England, and Belgium to clinical research sites in a number of African countries, is detailed in a STAT special report  published Thursday.

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Best Practices to Streamline Compensation Management: A Foundation for Growth

Speaker: Joe Sharpe and James Carlson

Payroll optimization can be one of the most time-consuming and complex factors of small business management. Yet, organizations that crack the code on streamlining employee compensation often discover innovative avenues for growth. With the right strategies in place, outsourcing and streamlining payroll processes can result in substantial time and resource savings.

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Clariant and OMV aim to reduce carbon footprint of ethylene and ethylene oxide derivatives

Express Pharma

Clariant, a sustainability focused specialty chemical company, and OMV recently announced their intended collaboration for the supply of ethylene with a lower carbon footprint. In response to increasing consumer demand for more sustainable options, and with a particular focus on Europe, this partnership will help both companies meet their sustainability targets and deliver on the carbon reduction strategies of their customers, informed the statement.

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STAT+: Private equity firms to acquire health care billing and payments firm R1 in $8.9 billion deal

STAT

R1 RCM is finally getting taken off the public markets, ending a months-long saga between private equity firms that were trying to take control of the large health care billing and collections company. Private equity firms TowerBrook Capital Partners and Clayton, Dubilier & Rice are teaming up to buy R1 , the companies said Thursday. TowerBrook, in a partnership with the Catholic hospital system Ascension, already owns 36% of R1 — which made TowerBrook and Ascension the company’

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UniQure restructuring to claim 300 jobs

BioPharma Dive

The job cuts affects 65% of UniQure’s workforce and include the gene therapy developer’s recent sale of a manufacturing plant to Genezen.

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venBio raises $528 million for its fifth fund

STAT

Want to stay on top of the science and politics driving biotech today?  Sign up  to get our biotech newsletter in your inbox. Good morning. We’ve got another busy day of earnings and new data readouts. Let’s get straight into it.

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Enhance Healthcare Efficiency With Top Payroll & HCM Services

Running a healthcare facility requires precision and care, not just for patients but also for your staff. Our guide, "A Buyer’s Guide to Payroll & HCM Services," helps healthcare providers choose the best provider. Efficient payroll management ensures timely, accurate payments, critical for maintaining staff morale and trust. Compliance support helps navigate complex healthcare regulations and avoid costly fines.

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Bateman Horne Center leads the way in ME/CFS and long COVID education

Outsourcing Pharma

The Bateman Horne Center of Excellence (BHC) has established itself as a trusted leader in the clinical care, provider education, patient advocacy, and research of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID.

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Listen: The long journey to make malaria vaccines, and Sarepta’s ties with patient advocates

STAT

Why has it taken so long for the world to get malaria vaccines? What relationship should drug companies have with patient advocates? And who in biotech is having a brat summer? We discuss all that and more in this week’s episode of “The Readout LOUD,” STAT’s biotech podcast. Andrew Joseph, our Europe correspondent, joins us to talk about his special report on the 40-year quest to develop the world’s first malaria vaccines.

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Changing Faces – Pharma and biotech May and June 2024

pharmaphorum

Stay updated on the latest hiring news and developments from Pfizer, Lilly, Gilead, Epsilogen, and other pharma and biotech companies in May and June 2024 with Changing Faces.

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Opinion: PBMs aren’t opening access to lower-cost biosimilars. Reform is needed now

STAT

The Federal Trade Commission presents on Thursday  its interim staff report , “Pharmacy Benefit Managers: The Powerful Middlemen Inflating Drug Costs and Squeezing Main Street Pharmacies.” It reveals how pharmacy benefit managers intentionally force people onto high-cost, high-rebate drugs. This report comes on the heels of Congress also  putting pressure on PBMs during a hearing that highlighted how these companies undermine patient health and increase drug costs.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Greg Smith appointed New Director of U.S. FDA India office

Express Pharma

The U.S. Food and Drug Administration (FDA) India office has announced the appointment of Greg Smith as its new Director. Smith, who previously served as the Deputy Director of the FDA India office, brings over 13 years of experience with the FDA to his new role. Before his tenure in India, Smith was the Director of the Center for Drug Evaluation and Research’s (CDER) Special Projects Staff, where he led a multi-disciplinary team tackling complex scientific, regulatory, legislative, and operatio

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STAT+: Pharmalittle: We’re watching positive Zepbound cardiovascular data, a move to take 23andMe private, and more

STAT

Greetings from London, with STAT reporter Andrew Joseph here filling in for Ed for the day. We’ve shifted to our afternoon version of a cup of stimulation (a nice glass of iced tea — it is summer after all), which is tasting extra delicious given that we just read a Wall Street Journal story on the Olympic triathlon that featured this review on the Seine swim: “It didn’t taste great.

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Going beyond the hype: Embracing AI for strategic advantage

pharmaphorum

Discover how AI is revolutionising the medical and pharmaceutical industries. Learn how to leverage AI for strategic advantage and stay ahead of the competition in this insightful article.

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STAT+: On Andrew Left and the government’s fraud case

STAT

I love the Summer Olympics. Every four years I transform into a huge fan of gymnastics and swimming, probably like all of you. But I also find myself obsessed with some of the nichier sports — handball, rowing, fencing! Go USA! As a reporter who spends most of his time at the intersection of biotech and Wall Street, I know Andrew Left, the short seller indicted by the government on fraud changes.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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IIT Kanpur researchers map structure of key Cell Receptor, enabling targeted drug development

Express Pharma

A research team from the Indian Institute of Technology Kanpur (IITK), led by Prof Arun K. Shukla from the Department of Biological Sciences and Bioengineering, has mapped the complete structure of the Duffy antigen receptor. This receptor, found on the surface of red blood cells and other cells, is a critical target for pathogens such as the malaria parasite Plasmodium vivax and the bacterium Staphylococcus aureus, making it a key focus for developing new drugs to combat these infections.

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South Africa's HIV Research: Unlocking the mysteries of elite controllers

pharmaphorum

South Africa occupies a pivotal position in the global battle against HIV. As of 2022, it is home to around 7.8 million individuals living with HIV, representing the largest HIV burden in the world. However, it is this very challenge that has placed South Africa at the leading edge of innovative HIV research, with potential ramifications for the millions affected by the disease globally - and that starts with elite controllers.

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GP action bound to have ‘ripple effect’ on already-strained pharmacies

The Pharmacist

Community pharmacy has lost much of its ability 'to be a shock absorber' for other parts of primary care, sector leaders have warned as GP collective action begins today. And they have called for 'a new deal' for the community pharmacy sector in addition to resolving government disputes with GPs. Having voted overwhelmingly in favour […] The post GP action bound to have ‘ripple effect’ on already-strained pharmacies appeared first on The Pharmacist.

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Vividion Therapeutics to expand with new global research and development center

World Pharma News

Vividion Therapeutics, Inc. (Vividion), a clinical stage biopharmaceutical company utilizing novel discovery technologies to unlock high-value, traditionally undruggable targets with precision therapeutics for devastating cancers and immune disorders, announced it will expand its global innovation capabilities with a new research and development (R&D) center and corporate headquarters in San Diego, California.

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GPs vote to take 'collective action'

The Pharmacist

An overwhelming majority (98.3%) of GPs balloted by the British Medical Association (BMA) have voted in favour of taking 'collective action'. The BMA will therefore be encouraging the profession to pick from a list of actions to take from today (1 August). The proposed action includes limiting daily contacts per clinician to 25 and switching […] The post GPs vote to take 'collective action' appeared first on The Pharmacist.

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NICE recommends BeiGene’s MZL tablet for NHS use

Pharmaceutical Technology

The UK NICE has recommended BeiGene’s Zanubrutinib for marginal zone lymphoma (MZL) for use on the National Health Service (NHS).

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Study finds ovarian cancer-treated women less likely to develop breast cancer

Pharma Times

Combined, ovarian and breast cancer affect over 60,000 women in the UK every year

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Valneva, LimmaTech ally on quest for first Shigella vaccine

pharmaphorum

Valneva has bolstered its vaccines pipeline with a shot designed to protect against shigellosis – a major global health threat – licensed from LimmaTech Biologics.The French pharma company – best known for its COVID-19 jab and recent approval for the world's first chikungunya vaccine Ixchiq – is paying €10 million upfront for a stake in LimmaTech's S4V vaccine candidate, and promising undisclosed regulatory, development and sales-based milestone payments.

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Axxelent receives its first US FDA Establishment Inspection Report (EIR)

Express Pharma

Axxelent Pharma Science (“Axxelent”) has announced the receipt of first EIR from US FDA for its oral solid dosage facility situated in Sri City SEZ, AP. US FDA inspected the facility from June 17 to 21, 2024. Commenting on the outcome of the inspection, Jitesh Devendra, Co-Founder and Chairman, said, “ W e are very glad about the outcome of our first US FDA inspection for our oral solid dosage facility.

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Bayer files first application of menopause drug elinzanetant

pharmaphorum

Bayer files elinzanetant as a non-hormonal treatment for menopausal symptoms, with Astellas' first-to-market Veozah in its sights

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