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Episode 918: What Happens If You Give a Cephalosporin to a Patient With Moderate, Severe, or Unknown Beta-Lactam Allergy?

Pharmacy Joe

Subscribe on iTunes , Android , or Stitcher The label of “penicillin allergic” usually sticks to a patient’s medical record forever. A 50 y/o male with an SSTI had an unknown allergy to penicillin, received a single dose of ceftriaxone in the ED and was then switched to piperacillin-tazobactam as an inpatient.

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Episode 852: Does Europe Do Apixaban Renal Dosing Better (Safer) Than the US?

Pharmacy Joe

The US labeling states: Anti-FXa activity adjusted for exposure to apixaban was similar across renal function categories. Using inverse probability of treatment weighting analysis, the US labeling recommendation of apixaban 5 mg was associated with a higher risk of bleeding at an incidence rate 4.9 or greater. mg twice daily.

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Episode 852: Does Europe Do Apixaban Renal Dosing Better (Safer) Than the US?

Pharmacy Joe

The US labeling states: Anti-FXa activity adjusted for exposure to apixaban was similar across renal function categories. Using inverse probability of treatment weighting analysis, the US labeling recommendation of apixaban 5 mg was associated with a higher risk of bleeding at an incidence rate 4.9 or greater. mg twice daily.

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Episode 902: The analgesic ceiling dose of ibuprofen applies to ED patients too

Pharmacy Joe

Back in episode 473 , I talked about the evidence behind the discrepancy between the labeled dose and the analgesic ceiling dose of IV ketorolac. ” To access my free download area with 20 different resources to help you in your practice, go to pharmacyjoe.com/free. There is similar data on the ceiling dose of ibuprofen as well.

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Episode 821: What dose of inhaled tranexamic acid is used for nonmassive hemoptysis?

Pharmacy Joe

If using this off-label strategy, give preference to the preservative-free version of IV tranexamic acid due to the potential adverse effects of nebulized preservatives. To access my free download area with 20 different resources to help you in your practice, go to pharmacyjoe.com/free. 009 in the tranexamic acid group).

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Episode 821: What dose of inhaled tranexamic acid is used for nonmassive hemoptysis?

Pharmacy Joe

If using this off-label strategy, give preference to the preservative-free version of IV tranexamic acid due to the potential adverse effects of nebulized preservatives. To access my free download area with 20 different resources to help you in your practice, go to pharmacyjoe.com/free. 009 in the tranexamic acid group).

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Episode 827: Early vs Late Anticoagulation in Stroke Due to Atrial Fibrillation

Pharmacy Joe

Authors recently published in New England Journal of Medicine an open label multi center trial looking at early vs later anticoagulation in patients with afib who had an ischemic stroke. To access my free download area with 20 different resources to help you in your practice, go to pharmacyjoe.com/free.