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STAT+: Pharmalittle: Chinese drugmakers develop copycat weight loss drugs; SEC eyes supplier of research monkeys

STAT

The Chinese companies hope to compete with the Danish pharma group Novo Nordisk’s pioneering drugs in China, which has the world’s largest overweight and diabetic population. If successful, they could also potentially offer a cheaper alternative in the West.

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Merck enhances ophthalmology portfolio with EyeBio acquisition

Pharmaceutical Business Review

This asset has potential applications in diabetic macular oedema (DME) and neovascular age-related macular degeneration (NVAMD). The acquisition includes EyeBio’s lead asset Restoret (EYE-103), a tetravalent, tri-specific antibody that targets the Wingless-related integration site (Wnt) signalling pathway.

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Merck & Co to repurpose failed obesity drug for NASH

pharmaphorum

Metabolic diseases is already a focus area for Merck & Co – it markets several diabetes drugs including Januvia (sitagliptin) and last year exercised an option to develop NGM313, an antibody developed by NGM that could be used in NASH and type 2 diabetes.

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Ophthalmology acquisition to advance tri-specific antibody

European Pharmaceutical Review

The treatment is expected to advance into a pivotal Phase IIb/III trial in diabetic macular edema in the second half of 2024. This is based on positive results from the Phase Ib/IIa AMARONE study in diabetic macular edema (DME) and neovascular age-related macular degeneration (NVAMD).