STAT

APRIL 25, 2024

Now Baker is pushing forward in a different area of drug discovery research. A few years ago, his lab surprised scientists by constructing an AI-powered protein-folding prediction system rivaling Google’s DeepMind AlphaFold.

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Compounding Drug Development 349

STAT

FEBRUARY 26, 2024

A new update of the STAT Obesity Drug Tracker shows that at least 23 — about one-fifth — of the 105 obesity treatments in development or on the market are also being investigated for metabolic dysfunction-associated steatohepatitis, the fatty liver disease known as MASH (and previously called NASH ).

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Diabetes Compounding Drug Development 361

STAT

OCTOBER 24, 2023

The conference opened to the news that Merck had signed one of the biggest licensing deals in industry history — worth up to $22 billion — to partner on three of the compounds from ADC specialist Daiichi Sankyo. GSK followed up with an ADC licensing announcement of its own (if a much smaller one).

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Compounding Drug Development 340

World Pharma News

MARCH 8, 2024

A team of University of Michigan researchers has successfully modified a naturally occurring chemical compound in the lab, resulting in advanced lead compounds with anti-HIV activity.

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Compounding Drug Development 82

STAT

APRIL 2, 2024

The autoimmune drug, brepocitinib, is being steered by a company called Priovant Therapeutics, which was formed as part of a deal between Roivant and Pfizer in 2021.     It is one of the most-watched compounds in Roivant’s pipeline for multiple autoimmune indications. Continue to STAT+ to read the full story…

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Compounding Drug Development 300

Pharmaceutical Technology

FEBRUARY 23, 2023

Our chemists and formulation scientists review the properties of new drug candidates and “work their magic” to develop formulations that improve the exposure profile of the compound. However, the chances of improving the exposure profile of a drug that is highly cleared by formulation modification are limited.

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STAT

OCTOBER 25, 2024

By law, that should have prohibited compounding pharmacies from making copies of the drug, as they are allowed to do so only when the treatment is on the shortage list. The agency then made a sudden about-face, saying it would reconsider its decision and allow compounders to continue for the meantime.

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Compounding Compounding Pharmacies Diabetes Drug Development 219

pharmaphorum

NOVEMBER 12, 2020

The company was founded as a spin-off of the University of Bern and Swiss research institute NCCR TransCure in April 2019, and is focused on the development of a new class of drugs that work on endocannabinoids, a type of neurotransmitter that bind to the receptors in the brain targeted by cannabinoid compounds.

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Drug Development Compounding 106

STAT

JUNE 20, 2024

We have adjusted our settings to accept postcards and telegrams… After taking legal action last year, Eli Lilly filed even more lawsuits against several spas, compounders and wellness centers over unapproved versions of tirzepatide, which is the active ingredient in Mounjaro and Zepbound,   STAT notes.

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Diabetes Compounding Drug Pricing Drug Development 283

Pharmaceutical Technology

SEPTEMBER 12, 2022

Development bogged down by complexity. While there is an unmet need, drug development remains slow due to neurological complexity. “We Other approaches include Neuronasal’s through-the-nose drug based on N-acetylcysteine (NAC). The mechanism is complicated.

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Drug Development Compounding 94

Pharmaceutical Technology

SEPTEMBER 3, 2024

Syntekabio has entered a partnership with Enamine for supply, synthesis of compounds and synthetic drug development.

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Drug Development Compounding 52

Pharmaceutical Technology

APRIL 30, 2024

Discover Ligand Pharmaceuticals Inc's groundbreaking patent for compounds treating leukemia and hematopoietic disorders. Explore the versatile pharmaceutical compositions and potential applications for innovative drug development.

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Compounding Drug Development 52

PharmaTech

OCTOBER 10, 2023

Developing and manufacturing complex novel oral solid dose products of highly potent compounds requires specialized expertise. Learn more about creating a safe, efficient and scalable drug development program with HPAPIs in this eBook.

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Drug Development Compounding 52

European Pharmaceutical Review

DECEMBER 13, 2022

North American psychedelic drug developers Mindset, PharmAla, Mydecine and Psyence have signed with clinical research organisation (CRO) Clerkenwell Health to trial therapies for mental health conditions, in London, UK, to benefit from the country’s swift drug regulatory process.

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Compounding Drug Development 105

Pharmaceutical Business Review

FEBRUARY 7, 2024

Camino Pharma CEO and co-founder Gonul Velicelebi said: “Our Phase I study results showed that SBP-9330 has a favourable safety and tolerability profile and well-behaved pharmacokinetics in humans, supporting further clinical development and evaluation of the compound in a proof-of-concept study in smokers as an aid to smoking cessation. “We

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Drug Development Compounding 59

European Pharmaceutical Review

OCTOBER 31, 2022

Solving this before the clinical stage ensures the viability of compounds…” Addressing bioavailability challenges in the first phases of development is essential to help create the most robust product profile and increase the potential for success as small molecule drugs move to the clinic.

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Compounding Drug Development Pharmaceutical Companies Pharmaceutical Companies 125

pharmaphorum

MAY 4, 2022

Testing drug compounds on a chip designed to mimic human organs sounds closer to science fiction than reality, yet the technology already exists and is already being put to use. The limits of animal models in drug discovery are well known.

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Compounding Drug Development 143

European Pharmaceutical Review

NOVEMBER 25, 2024

The market is furthermore expected to see a compound annual growth rate (CAGR) of 7.3 An increasing trend of outsourcing boosts growth of the market as pharmaceutical companies are utilising advanced testing capabilities and optimising their drug development processes. billion by 2032. percent between 2024 and 2032.

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Drug Development Biosimilars Compounding Pharmaceutical Companies 52

Pharmaceutical Technology

NOVEMBER 3, 2022

The funding will be used for the Phase III clinical trial and potential marketing of the investigational compound, ecopipam, for treating Tourette syndrome patients. The Food and Drug Administration granted Orphan Drug and Fast Track designation for ecopipam to treat Tourette syndrome.

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Drug Development Compounding 52

European Pharmaceutical Review

DECEMBER 21, 2022

What sponsors should know about psychedelic drug development. Although some psychedelics have a long history in traditional medicine, regulatory agencies must evaluate psychedelic compounds the same way they assess any other drug. Psychedelic compounds are assessed by regulators the same way as any other drug.

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Compounding Drug Development Controlled Substances 119

Pharmaceutical Business Review

MARCH 7, 2024

Additionally, Sionna is progressing with the development of compounds targeting complementary mechanisms. This capital raise provides financial flexibility positioning us to execute our clinical development plan with funding through 2026 and multiple value-creating clinical readouts.”

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Drug Development Compounding 59

Pharmaceutical Technology

JUNE 15, 2023

Drug development is already a difficult endeavor, with the vast majority of R&D efforts failing to produce a market-worthy product. Even reaching the clinical trial phase offers no guarantees, as only 12% of such drugs receive U.S. While this process is essential, it’s also slow, expensive and unpredictable.

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Drug Development Compounding Adverse Reactions Dosage 52

pharmaphorum

JUNE 30, 2022

Digital technologies are already helping to enable target identification, lead discovery, preclinical development, and clinical development, said Merck. The hope is that by using AI and ML capabilities, the currently unpredictable process of drug development can become much more predictable, and as a result less expensive.

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Research Laboratories Drug Development Compounding 134

World Pharma News

AUGUST 9, 2024

The natural world is rich in chemical compounds with remarkable medicinal properties. This discovery revolutionized the treatment of bacterial infections and highlighted the potential of natural compounds in medicine. A notable example is penicillin, discovered by chance from the Penicillium mold.

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Compounding Drug Development 59

Syner-G

SEPTEMBER 15, 2023

This shift from a linear to a network approach enhances the potential for one drug to target multiple sites. Structure-based drug design has evolved, facilitating the exploration of novel chemical probes and lead compound potency, and molecular docking utilizes target structures to predict interactions and offers simplicity and speed.

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Drug Development Documentation Process Improvement Compounding 59

PharmaTech

MARCH 21, 2023

Thousands of drug candidates are abandoned annually due to solubility and bioavailability issues, but advanced formulation technologies can profoundly impact how a drug compound is processed in the body and improve the fate of many of these candidates, improving pharmacokinetic profiles and pharmacodynamic responses.

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Drug Development Compounding 40

European Pharmaceutical Review

JULY 13, 2023

3 With established drug development pathways, we are accustomed to a rigid structure of translation from bench to bedside. While this is essential in the interrogation of novel compounds for which we know very little about their efficacy and safety, it is also true that some biomedical research is highly wasteful.

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Compounding Drug Development Clinical Pharmacology Documentation 98

pharmaphorum

NOVEMBER 9, 2022

Sanofi has tapped into the artificial intelligence expertise of Chinese biotech Insilico Medicine with a six-compound drug discovery collaboration that could be worth up to $1.2 Insilico’s in-house drug development efforts are led by a drug against an as-yet undisclosed target in phase 1 clinical testing.

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Compounding Drug Development 111

European Pharmaceutical Review

FEBRUARY 27, 2023

Due to more biopharmaceutics classification system (BCS) II and BCS IV molecules being evaluated in early development, a market report has signalled that the bioavailability enhancement market will grow at a steady rate between 2022 to 2035.

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Compounding Drug Development 98

European Pharmaceutical Review

JULY 24, 2023

A paper published in Pharmaceutics has proposed how a personalised preparation quality assurance programme can achieve this when these products are developed in compounding laboratories. PACMI selects a drug on a quarterly basis. It requests that compounding laboratories adhering to the programme send samples of it.

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Compounding Documentation Drug Development 93

pharmaphorum

MARCH 24, 2022

GlaxoSmithKline has thrown its financial and drug development weight behind LifeMine Therapeutics, a US startup that aims to find new therapeutics from fungi – widely regarded as an underexplored resource of biologically-active compounds.

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Compounding Immunization Immunity Drug Development 105

European Pharmaceutical Review

JUNE 28, 2023

million by 2030, growing at a compound annual growth rate (CAGR) of 5.57 Growth of the pharmaceutical and biotechnology industries, plus the need for accurate and precise analytical tools in drug development and quality control are influencing factors. percent from 2023 to 2030. What is driving the HPLC market?

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Drug Development Compounding 98

pharmaphorum

JULY 21, 2021

The winning team relied on “handcrafted” features that incorporated their own insights into drug development timelines and which data entries should be discarded, according to MIT. The results were interesting, but the team wanted to do better. .

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Data Entry Drug Development Compounding 105

European Pharmaceutical Review

JULY 25, 2023

A compound annual growth rate (CAGR) growth of 5.9 Complex compounds offer targeted, effective medicines and typically outperform small molecule APIs. Disease areas Development of APIs for niche sectors such as rare or uncommon diseases offers new markets and can give small molecule API companies “an edge”, stated the report.

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Compounding Drug Development Generic Medicine Diabetes 97

PharmaTech

DECEMBER 17, 2024

Lucy Zhou, Skin Lab Manager, discusses the importance and applications for utilizing IVPT during formulation development of novel topical compounds to help select excipients and permeation enhancers that will properly deliver the drug into the desired layer of the skin or system.

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Drug Development Compounding 40

European Pharmaceutical Review

DECEMBER 16, 2022

According to a report by Future Market Insights (FMI), the global Alzheimer’s therapeutics market is expected to grow at a compound annual growth rate (CAGR) of 9.3 FMI stated drug manufacturers have been unable to validate the significant clinical benefits of treatment for numerous new compounds due to strict regulations.

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Compounding Immunization Immunity Drug Development 98

Express Pharma

JUNE 11, 2024

With the evolving landscape of drug development and innovations, several institutes are serving as catalysts by partnering with pharmaceutical companies to drive progress at various stages of research and development.

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Pharmaceutical Companies Pharmaceutical Companies Drug Development Compounding 105