Clinical Pharmacology and Presentation

Clinical Pharmacology

Presentation

ACMT Toxicology Visual Pearl: Who Doesn’t Like a Nice Rosé?

ALiEM - Pharm Pearls

NOVEMBER 1, 2023

What clinical presentation and medication is associated with this urinary discoloration? Hypersensitivity reactions to rifampin: Pathogenetic mechanisms, clinical manifestations, management strategies, and review of the anaphylactic-like reactions. Medicine (Baltimore) 1999;78(6):361-9. PMID 10575418 Kaakkola S.

Clinical Pharmacology

Clinical Pharmacology Dosage Compounding

FDA drug dosage optimisation guidelines signal clinical trial reform

Pharmaceutical Technology

FEBRUARY 17, 2023

Ratain says achieving the right dosage requires an understanding of clinical pharmacology and a randomised trial. The clinical pharmacology knowledge also isn’t present at smaller companies, he adds. The MTD model made sense for early cancer studies when most drugs had non-specific targets, says Veal.

Dosage

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Trending Sources

The future of medical cannabis development in Europe

European Pharmaceutical Review

JULY 13, 2023

Cannabis complications There are notable complexities to researching medical cannabis using a linear approach to clinical translation. 5 These are each present at varying concentrations depending on underlying plant genetics and growing conditions. Expert Review of Clinical Pharmacology. British journal of pharmacology.

Compounding

Compounding Drug Development Clinical Pharmacology Documentation

New Initiative of the US FDA: The Role of Pharmacodynamic Biomarkers for the Development of Biosimilar

PharmaShots

APRIL 6, 2023

A recent study published in the January 2023 issue of Clinical Pharmacology and Therapeutics described essential characteristics of a PD biomarker for biosimilar development.

Biosimilars

Biosimilars Clinical Pharmacology

Episode 573: Ceiling dose of ketorolac for renal colic in the ED

Pharmacy Joe

JANUARY 10, 2021

In 1989, a study in the Journal of Clinical Pharmacology compared 10, 30, and 90 mg of IM ketorolac with placebo in 126 patients with cancer pain. While all doses were more effective than placebo, there was no difference in effectiveness between 10, 30, or 90 mg of IM ketorolac. 165 patients were split evenly between the 3 groups.

Clinical Pharmacology

Clinical Pharmacology Inpatient Dosage Documentation

Uncovering the potential of ADCs to target tumours

European Pharmaceutical Review

JULY 18, 2024

This covers nonclinical drug safety, translational and clinical pharmacology, drug metabolism and pharmacokinetics (DMPK) and pharmacometrics. Exploration of the antibody–drug conjugate clinical landscape. Rise of Antibody-Drug Conjugates: The Present and Future. Signal Transduct Target Ther. 2022; 7(93) Maecker et al.

Chemotherapy

Chemotherapy Clinical Pharmacology

ACMT Toxicology Visual Pearl: The Bark with Some Bite

ALiEM - Pharm Pearls

MARCH 5, 2024

How does willow bark toxicity present? [7] 7] Toxicity from salicin mirrors toxicity from aspirin (salicylism) in its clinical presentation. European Journal of Clinical Pharmacology. European Journal of Clinical Pharmacology. British Journal of Haematology. 2017;177(5):674-683. PMID: 28106908.

Clinical Pharmacology

Clinical Pharmacology Adverse Reactions Compounding

Top 9 Takeaways From 2232 People With Hashimoto’s

The Thyroid Pharmacist

DECEMBER 28, 2022

Interestingly, Dr. Robert Krysiak and colleagues from the Department of Internal Medicine and Clinical Pharmacology at the Medical University of Silesia in Katowice, Poland, published an article about the benefits of the gluten-free diet in Hashimoto’s in 2019.

Immunity

Immunity Immunization Clinical Pharmacology Doctor of Pharmacy

Zydus receives USFDA approval to conduct Phase II(b) clinical trial for Usnoflast, a novel oral NLRP3 inflammasome inhibitor in patients with ALS

Express Pharma

JANUARY 19, 2025

Zydus has previously completed a Phase 2(a) randomised, double-blind, placebo-controlled clinical trial in 24 ALS patients across 7 clinical trial sites in India. It is planned to present this Phase 2(a) trial data in an upcoming medical conference and publish in a medical journal. DOI: 10.1002/cpdd.1162 DOI: 10.1002/cpdd.1318.

Clinical Pharmacology

Clinical Pharmacology Labelling Medical Schools Drug Development

Twenty Women Leaders In Healthcare Industry

PharmaShots

MARCH 9, 2023

We are esteemed and elated to present a list of the 20 women who have excelled in reaching the summit of excellence, arranged alphabetically Total experience: 16 yrs. Present company and time period: Pfizer (2 yrs.) Present company and time period: Sensium Healthcare (6 yrs. Present company and time period: Pfizer (26 yrs.)

Clinical Pharmacology

Clinical Pharmacology Immunity Immunization Pharmaceutical Companies

Developing new treatment regimens for HIV

European Pharmaceutical Review

MARCH 11, 2024

For more than 15 years, integrase strand transfer inhibitors (INSTIs) have served as the foundation of ART regimens in HIV treatment guidelines around the world and our present portfolio is built on them. With therapeutic expertise in HIV, hepatology and rare diseases, Sherene has additional expertise in clinical pharmacology and drug safety.

Immunity

Immunity Immunization Clinical Pharmacology Drug Development

7. Reflections on a Career in Pharmacy and Medicine with Dr. Steven Berk

The Physician Pharmacist

OCTOBER 27, 2023

You know, he was the kind of guy you trembled in your boots when you present it in front of him. And he called people up to present cases and I was the PharmD. And I worked really hard on the presentation and I didn't think he anything it would be it was shared with a physician. Yeah, he was. He was old school. He got me up.

Medical Schools

Medical Schools Medical Records Hospitals Clinical Pharmacology

Alzheimer’s drug requires strengthened pharmacovigilance approach

European Pharmaceutical Review

MARCH 7, 2025

A paper published by the Drug Safety Research Unit (DSRU) in the British Journal for Clinical Pharmacology , has asserted the need for ongoing assessment of the safety and effectiveness of the Alzheimers drug lecanemab in the real-world clinical setting.

Clinical Pharmacology

FDA Guidance Outlines a Framework for the Evaluation of Long-Term Neurodevelopmental Safety Studies in Neonatal Product Development

FDA Law Blog: Biosimilars

OCTOBER 28, 2024

raw scores, standardized norm-referenced scores), some of which might present floor or ceiling effects; and ensuring that selected COAs have demonstrated reliability across demographic groups. When a comprehensive neurodevelopmental evaluation is needed, it should include an evaluation of physical, mental, and social health.

Clinical Pharmacology

Clinical Pharmacology Communication Drug Development

Pharmacist Digest

ACMT Toxicology Visual Pearl: Who Doesn’t Like a Nice Rosé?

FDA drug dosage optimisation guidelines signal clinical trial reform

Trending Sources

The future of medical cannabis development in Europe

New Initiative of the US FDA: The Role of Pharmacodynamic Biomarkers for the Development of Biosimilar

Episode 573: Ceiling dose of ketorolac for renal colic in the ED

Uncovering the potential of ADCs to target tumours

ACMT Toxicology Visual Pearl: The Bark with Some Bite

Top 9 Takeaways From 2232 People With Hashimoto’s

Zydus receives USFDA approval to conduct Phase II(b) clinical trial for Usnoflast, a novel oral NLRP3 inflammasome inhibitor in patients with ALS

Twenty Women Leaders In Healthcare Industry

Developing new treatment regimens for HIV

7. Reflections on a Career in Pharmacy and Medicine with Dr. Steven Berk

Alzheimer’s drug requires strengthened pharmacovigilance approach

FDA Guidance Outlines a Framework for the Evaluation of Long-Term Neurodevelopmental Safety Studies in Neonatal Product Development

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