ALiEM - Pharm Pearls

NOVEMBER 1, 2023

What clinical presentation and medication is associated with this urinary discoloration? 1,2] Severe symptoms such as hypovolemia, shock, metabolic acidosis Persistent and severe GI symptoms Lethargy or toxic appearance Serum iron level greater than 500 mcg/dL What is the dosage of deferoxamine for iron toxicity? [1]

Clinical Pharmacology 161

Clinical Pharmacology Dosage Compounding 161

Pharmacy Joe

JANUARY 10, 2021

In 1989, a study in the Journal of Clinical Pharmacology compared 10, 30, and 90 mg of IM ketorolac with placebo in 126 patients with cancer pain. Either FDA approval of a lower dosage size or an automatic substitution policy would likely be required to get IV ketorolac doses down to 10 mg routinely.

Clinical Pharmacology 40

Clinical Pharmacology Inpatient Dosage Documentation 40

Pharmaceutical Technology

FEBRUARY 17, 2023

In January, amidst calls to improve patient safety by optimizing licensed drug formulations, the FDA released a draft guidance that signalled a departure from the most commonly used method of identifying a new therapy’s ideal dosage. The focus on identifying the ideal drug dosage is not new. What is drug dose optimisation?

Dosage 115

Dosage Clinical Pharmacology Pharmaceutical Companies Pharmaceutical Companies 115