ALiEM - Pharm Pearls

MARCH 5, 2024

The active compound, salicin, is metabolized to salicylic acid in the body providing analgesic and antipyretic effects [2]. European Journal of Clinical Pharmacology. European Journal of Clinical Pharmacology. Willow tree bark contains salicin from which aspirin (acetylsalicylic acid) can be derived.

Clinical Pharmacology 286

Clinical Pharmacology Adverse Reactions Compounding 286

European Pharmaceutical Review

JUNE 28, 2022

Some examples of HPAPIs are cytotoxic compounds and hormones such as oestrogen. A new compound of unknown potency and toxicity. Over 25 percent of total drugs worldwide are classified as containing HP compounds and 30 percent of product candidates in the development pipeline are also HPAPIs, showing that this trend will continue.

Dosage 96

Dosage Clinical Pharmacology Compounding 96

ALiEM - Pharm Pearls

NOVEMBER 1, 2023

 Deferoxamine binds with ferric iron (Fe3+) to form ferrioxamine, a water-soluble compound excreted in the urine. As Hypersensitivity reactions to rifampin: Pathogenetic mechanisms, clinical manifestations, management strategies, and review of the anaphylactic-like reactions. Medicine (Baltimore) 1999;78(6):361-9.

Clinical Pharmacology 161

Clinical Pharmacology Dosage Compounding 161

European Pharmaceutical Review

MARCH 6, 2024

Additionally, the new laboratory offers Ariceum the ability to carry out on-site process, method, validation and formulation development as well as preliminary stability analysis of its radiolabeled compounds.

Method Validation 105

Method Validation Clinical Pharmacology Compounding 105

PharmD Live

MAY 30, 2024

The side effects can compound, resulting in a greater negative impact on a patient’s health than the individual effects of one medication alone. British Journal of Clinical Pharmacology, 67(6), 689–700. Retrieved from British Journal of Clinical Pharmacology Jyrkka, J., A., & O’Mahony, M. Korhonen, M.

Clinical Pharmacology 119

Clinical Pharmacology Hospitals Long-Term Care Facilities Dosage 119

Eye on FDA

AUGUST 4, 2021

When Breakthrough Therapy (BT) designation is granted, then the drug gets Fast Track status and receives more intensive guidance – which can begin as early as Phase I clinical trials. That said, BT would be a lagging indicator since it can be granted so early in the development process.

Clinical Pharmacology 122

Clinical Pharmacology Compounding Vaccines 122

Pharmaceutical Technology

DECEMBER 16, 2022

This year saw great progress towards making new therapeutics for malaria available sooner rather than later, says Karen Barnes, PhD, professor at the University of Cape Town’s Division of Clinical Pharmacology. The company now expects to complete its submission for a BLA with the FDA by the end of the year.

Drug Development 105

Drug Development Vaccines Clinical Pharmacology Compounding 105