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Opinion: A challenge trial can streamline testing of hepatitis C vaccines

STAT

Chemotherapy can save people from cancer, but the side effects can wreak havoc on their bodies for months or years. Trade-offs in medicine can be harsh, even when clearly necessary. These trade-offs aren’t limited to the clinical world. They are also part of research.

Vaccines 246
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Opinion: Doctors need to pay more attention to non-physical side effects of health care

STAT

Chemotherapy leaves a person fatigued and nauseated. Treatments for sickle cell anemia can lead to infertility, and even routine vaccines sometimes have you nursing a sore arm for days. It’s common for patients and physicians to decide whether a treatment is worth it by weighing the health benefits against the side effects.

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STAT+: Foundation charges cancer patients $83,000 for unproven but promising experimental drug

STAT

Still, when doctors told her last year that the cancer was growing despite two operations, radiation therapy, and a fifth regimen of chemotherapy, the retired business-meeting facilitator decided to do something unorthodox: spend $83,000 out of pocket on an unproven experimental cancer vaccine.

Vaccines 246
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Imugene HER2 vaccine hits target in stomach cancer trial

pharmaphorum

A peptide vaccine developed by Australia’s Imugene has reduced tumour size in around half of patients with HER2-positive gastric or gastroesophageal junction (GEJ) cancer in a phase 2 trial. The post Imugene HER2 vaccine hits target in stomach cancer trial appeared first on.

Vaccines 119
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Novel vaccine delivers significant survival in lung cancer trial

European Pharmaceutical Review

A T-cell epitope cancer vaccine significantly improved overall survival in non-small cell lung cancer (NSCLC) compared to chemotherapy, Phase III data published in Annals of Oncology has shown. percent with chemotherapy. The cancer vaccine offered an overall survival of 11.1 months for chemotherapy.

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Could personalised mRNA vaccine be first for cancer?

European Pharmaceutical Review

A BioNTech-led Phase I trial demonstrated preliminary evidence that adjuvant autogene cevumeran, a personalised mRNA neoantigen vaccine, in combination with atezolizumab (Genentech) and mFOLFIRINOX can induce substantial T cell activity in pancreatic ductal adenocarcinoma (PDAC). Can an mRNA vaccine stimulate T cell response?

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Vaccine demonstrates benefit in delaying cancer relapse

European Pharmaceutical Review

A lymph node-targeted cancer vaccine has shown potential to prevent relapse of KRAS-mutated pancreatic and colorectal cancers in patients who have had surgery, according to a Phase I trial led by US researchers. Patients were given no more than 10 doses of the ELI-002 cancer vaccine targeted toward KRAS G12D and G12R mutations. “It