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An increasing challenge in the treatment of oral cancer is that tumors become resistant to chemotherapy. These studies often do not make a splash in the field and are almost never presented at major meetings, yet they provide guidance as to how best to harness the power of this technology.
It responds poorly to chemotherapy and is usually driven by a mutation that can’t be drugged with traditional approaches. But in a clinical trial presented last year , 14 out of 50 patients with relapsed disease saw their tumors shrink. Median survival is generally cited as less than a year.
Results presented from the Phase III IMpower133 study and extension trial IMbrella A, show Roche’s Tecentriq (atezolizumab), in combination with chemotherapy, demonstrates a potential long-term overall survival (OS) benefit as first-line treatment for extensive-stage small cell lung cancer (ES-SCLC). Presented at WCLC 2023.
On Monday, data presented here from a trial of the drug in advanced non-small cell lung cancer provided at least a fuller look. Patients were randomized to either receive chemotherapy or Dato-DXd, which AstraZeneca is developing with Daiichi Sankyo. Continue to STAT+ to read the full story…
MADRID — Results presented Monday could expand the use of a Novartis therapy for metastatic prostate cancer, moving it from a treatment used after chemotherapy to one with demonstrated benefits beforehand as well.
CHICAGO – An experimental drug dramatically slowed the growth of glioma, a type of brain cancer, if the tumor carried a specific type of genetic alteration, researchers said Sunday, potentially sparing patients exposure to radiation and chemotherapy.
WASHINGTON — Congress is considering a must-pass pandemic preparedness bill that presents a good opportunity to fix the nation’s current drug shortages problem, which both parties want to do. But most indications are that lawmakers will let that opportunity pass them by.
When it hit the market in 2013, the drug revolutionized the treatment of these cancers and represented a major step forward from chemotherapy and some other drugs at the time. NEW ORLEANS – One of the best therapies for some types of lymphoma and leukemia has been a drug called ibrutinib, made by AbbVie.
The PHERGain II study’s goal is to find an effective therapeutic strategy that can reduce the use of chemotherapy and improve the quality of life of patients without compromising the clinical effectiveness of their treatment.
So join us as we hoist the ever-present cup of stimulation — our choice today is gingerbread — and attack the fast-growing to-do list. Cisplatin is a type of chemotherapy drug used alone or in combination with other drugs to treat several advanced forms of cancer, including bladder, ovarian and testicular cancer.
The company aims to reduce the toxic effects of chemotherapy and chances of cancer relapse improving the quality of lives of patients suffering from cancer. The company also plans to present its data for CDSCO approval, strengthen the team size along with expanding its product marketing and sales at a global level.
So join us as we hoist the ever-present cup of stimulation — our choice today is coconut rum — and attack the fast-growing to-do list. The medicine, Dato-DXd, is a type of next-generation chemotherapy called an antibody-drug conjugate that AstraZeneca and other companies are investing in heavily.
Data from the second interim analysis of the DETECT V trial, presented at ESMO Congress 2024, suggest that a chemotherapy-free regimen combining dual HER2-targeted therapy with endocrine therapy, particularly with the addition of ribociclib, may be an effective treatment for patients.
Published date: 17/04/2023 Summary: Cantargia (Cantargia AB; Nasdaq Stockholm: CANTA) today presented updated interim clinical efficacy data including subgroup analyses of first-line pancreatic cancer (PDAC) patients treated with the antibody nadunolimab (CAN04) and chemotherapy in the phase I/IIa CANFOUR trial. months; p=0.017).
Epicur Pharma’s Advisory Council member Ann Donoghue, DVM, MS shares her personal perspective on the important relationship between veterinary oncology and compounded medications used in chemotherapy treatments. Many of the presentations discussed the chemotherapies available to treat dogs.
pharmaphorum sat down with Sunil Verma, global head of oncology, medical, at AstraZeneca, to discuss three studies that were presented at the show, which demonstrate a few of the ways oncology is advancing through precision medicine and targeted therapies. And once it’s present there, it’s taken up by the cancer cell.
A vast majority of patients diagnosed with CRPC already present with metastases at the time of diagnosis. The findings will be presented at an upcoming medical meeting and submitted to the FDA for regulatory approval in 2023. Prostate cancer is the most frequently diagnosed cancer in men in 112 countries.
These early data “indicate the potential for the anti-TIGIT, domvanalimab-based therapy to improve upon anti-PD-1 and chemotherapy in this setting, with a similar safety profile to anti-PD-1 and chemotherapy,” Dr Janjigian added. The treatment is being evaluated in patients with upper GI adenocarcinomas.
Earlier this week on 11 September, while still known as Janssen Pharmaceutical Companies of Johnson & Johnson, the firm announced that RYBREVANT ® (amivantamab-vmjw) and Lazertinib plus chemotherapy provided a median progression-free survival (PFS) rate of 14 months in previously treated EGFR-mutated advanced non-small cell lung cancer (NSCLC).
Historical SOC involves platinum-based salvage combination chemoimmunotherapy regimen followed by high-dose therapy (HDT) and stem cell transplant (ASCT) in patients who respond to salvage chemotherapy. According to Kite, these findings will be presented in full later this year at an upcoming scientific meeting.
Pills can present significant challenges for certain patients around administration, eg, for those who have difficulty swallowing liquids or solids. 2,3 In addition, the accessibility gap for treatment with pills can be widened by other factors such as the side effects of chemotherapy.
A Phase III clinical trial evaluating pembrolizumab with chemotherapy (carboplatin and paclitaxel), improved progression free survival (PFS) for stage III-IV or recurrent endometrial carcinoma. The full results of this trial will be presented at an upcoming scientific conference.
Individuals with this aggressive brain cancer have limited treatment options, which include surgery, radiotherapy, chemotherapy, and best supportive care. Further to NICE’s present recommendation, last week, Novartis released promising new data for Fabhalta ® (iptacopan) as a treatment for the kidney disease IgA nephropathy (IgAN).
Ninety-four percent of advanced stage (3 or 4) classic Hodgkin lymphoma patients treated with nivolumab, a PD-1 checkpoint inhibitor plus AVD chemotherapy (N-AVD) had one-year progression-free survival (PFS), according to Phase III trial results.
On assessing zanubrutinib against the main therapies presently used by NHS England, the NICE committee noted that it was clinically effective as well as could aid WM patients to live longer. Current treatment options include chemotherapy and immunotherapy, but these can severely impact people’s quality of life.”.
China-based Innovent Biologics recently presented Phase I study results of its first-in-class anti-CLDN18.2/CD3 Currently, chemotherapy remains the mainstay of treatment across the first and second line for advanced pancreatic cancer. Recently, IBI343 Phase I clinical data (NCT05458219) was presented at ASCO.
The biologic ZL-1310 is being investigated in an ongoing Phase Ia/Ib study in these patients who have had at least one platinum-based chemotherapy regimen. This initial data on ZL-1310 was presented this week at the EORTC-NCI-AACR (ENA) Symposium 2024.
Updated using the pre|CISION technology, AVA6000 is a kind of generic chemotherapy doxorubicin. At present, AVA6000 is being analysed in a Phase I clinical trial underway to evaluate its safety and pharmacokinetics to potentially treat patients with various types of cancers, including soft tissue sarcoma.
Janssen, part of Johnson & Johnson, has announce new long-term data from its CHRYSALIS study, which assessed Rybrevant (amivantamab) in patients with advanced non-small cell lung cancer (NSCLC) and epidermal growth factor receptor (EGFR) exon 20 insertion mutations whose disease continued to progress while receiving platinum-based chemotherapy.
Future developments for lung cancer treatment TAGRISSO AstraZeneca stated that the data will be presented at a forthcoming medical meeting and distributed to regulators globally. TAGRISSO as a combination treatment with chemotherapy was recently approved in the US, based on data from the FLAURA2 Phase III trial.
Yescarta is administered to the patient via a single intravenous infusion following the administration of a round of chemotherapy designed to accommodate the new cells and minimise the patient’s immune reaction to them. About 50% will ultimately relapse post-transplant.
Additionally, data from the SCARLET trial presented at ASCO 2023 indicate the safety and efficacy of sotorasib in combination with platinum-based chemotherapy treating non¬–small cell lung cancer.
The UK Medicines and Healthcare products Regulatory Agency (MHRA) granted conditional approval for Retsevmo (selpercatinib) as monotherapy for adults with advance RET fusion-positive non-small cell lung cancer requiring systemic therapy after previous immunotherapy and/or chemotherapy treatment.
The filing is based on findings of the innovaTV 204 phase 2 single-arm trial, in 101 patients with recurrent or metastatic disease previously treated with doublet chemotherapy and Roche’s Avastin (bevacizumab) if appropriate. Tisotumab vedotin is made up of a toxic drug attached to the tail end of an antibody.
per cent, CRC presents a significant growth opportunity. The key opinion leaders (KOLs) interviewed by GlobalData highlighted that tolerability remains a highly sought-after quality with developing therapies, as highly prescribed chemotherapies containing oxaliplatin often lead to serious adverse events and discontinuation.
Then chemotherapy treatment was performed to eliminate their remaining bone marrow, providing space for the repaired cells to be infused back into their body afterwards. Preliminary clinical trial data is being presented at the European Haematology Association (EHA) Hybrid Congress in Germany.
It is to be used in combination with other antiemetic agents to prevent both acute and delayed nausea and vomiting following highly emetogenic cancer chemotherapy (HEC), including high-dose cisplatin, as well as with moderately emetogenic cancer chemotherapy (MEC).
NICE has backed regular NHS funding England and Wales for Merck, Sharp and Dohme’s Keytruda in combination with pemetrexed and platinum chemotherapy in certain lung cancer patients. It is therefore all the more important that clinicians have the best choices available for their patients.”.
GSK has received the US Food and Drug Administration’s (FDA) acceptance for its supplemental Biologics License Application (sBLA) for Jemperli (dostarlimab) along with standard-of-care chemotherapy (carboplatin and paclitaxel).
Shots: The P-III study (TROPiCS-02) evaluating Trodelvy vs CT in a ratio (1:1) in 543 patients with HR+/HER2- metastatic breast cancer who progressed on endocrine-based therapies and 2 chemotherapies In the exploratory analysis, improvement in m-OS benefit (14.5 vs 11.2mos.), PFS rates at 6/12/18mos. vs 29.4%)/ (21.7% vs 8.4%)/ (14.4%
Until now people with AL amyloidosis have had to rely on chemotherapy, with its accompanying side effects, and other drugs to tackle organ failure once damage gets severe. Amyloid plaques can then form in multiple organs such as the heart, kidneys and liver, damaging them and in some cases leading to organ failure.
The US Food and Drug Administration (FDA) has granted approval for AstraZeneca ’s Imfinzi (durvalumab) plus Imjudo (tremelimumab) and platinum-based chemotherapy to treat Stage IV (metastatic) non-small cell lung cancer (NSCLC) in adults.
The Medicines and Healthcare products Regulatory Agency (MHRA) has granted conditional marketing authorisation to Exkivity (mobocertinib) as a monotherapy for non-small-cell lung cancer (NSCLC) patients whose tumours have EGFR exon20 insertion mutations, after first-line chemotherapy.
Patients in the US and EU with recurrent or metastatic nasopharyngeal carcinoma (NPC), a subtype of head and neck squamous cell carcinoma (HNSCC), are mostly treated with a combination of chemotherapy agents in the frontline setting, such as cisplatin + gemcitabine. months for the chemotherapy arm (hazard ratio [HR]: 0.52).
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