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After years of development, revised compounding standards from United States Pharmacopeia (USP) became effective on November 1, 2023. USP Chapter <795> focuses on nonsterile compounding, with updates aimed at improving quality, safety, and consistency.
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The authors consider extremely hypotonic solutions to be 0.225% sodium chloride (also called one-quarter normal saline) and sterile water for injection. In addition, 0.225% sodium chloride must be compounded which comes with a risk of compounding error. Both of these solutions have a high risk of hemolysis.
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The authors consider extremely hypotonic solutions to be 0.225% sodium chloride (also called one-quarter normal saline) and sterile water for injection. In addition, 0.225% sodium chloride must be compounded which comes with a risk of compounding error. Both of these solutions have a high risk of hemolysis.
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