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AstraZeneca’s Lynparza to dominate PARP inhibitors market with $4 bn in sales by 2027: GlobalData

Express Pharma

In 2014, the FDA approved the first (adenosine diphosphate-ribose) polymerase (PARP) inhibitor AstraZeneca /Merck’s Lynparza (olaparib) for use in breast cancer gene (BRCA)-mutated metastatic ovarian cancer patients who have received three or more prior lines of chemotherapy.

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MSD secures full approval for Keytruda’s use in MSI-high solid tumours

Pharmaceutical Technology

On March 27, MSD announced that the combined use of Keytruda with chemotherapy significantly improved progression-free survival versus the chemotherapy alone, as a first-line therapy for advanced or recurrent endometrial carcinoma. billion in 2028. This announcement is not the only recent development for Keytruda.

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More big wins for the AstraZeneca-Daiichi Sankyo collaboration

Pharmaceutical Technology

Enhertu has already achieved regulatory approval as a second-line therapy for metastatic or recurrent HER2-positive breast cancer, as well as HER2-positive gastric or gastroesophageal junction adenocarcinoma, with annual sales for these indications alone expected to exceed $1.3bn by 2028.

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Colorectal cancer market across 8MM to reach $21.8 bn in 2031: GlobalData

Express Pharma

Thomas Wales, Oncology Analyst at GlobalData, comments, “While the CRC market will see steady growth throughout the forecast period, the patent expiry of MSD’s popular immunotherapy Keytruda (pembrolizumab) in 2028 is expected to cause some contraction in the market.

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Pfizer acquires ADC pioneer Seagen for $43bn

Pharmaceutical Technology

The drug is currently licensed in combination with chemotherapy for patients with classical Hodgkin lymphoma, both as frontline therapy and for those at risk of progressing or having progressed following stem cell transplantation. compound annual growth rate (CAGR) according to Pfizer’s risk-adjusted projection.

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Roche scores phase 3 win for subcutaneous Tecentriq, eyes filings

pharmaphorum

The trial involved cancer immunotherapy-naïve patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) patients who were getting treatment with Tecentriq second-line after earlier platinum-based chemotherapy failed. Results from a trial in first-line NSCLC are due in early 2023.

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A history of blood cancer treatment

pharmaphorum

While they may not have known it at the time, through their work Ehrlich and Metschnikow formed the cornerstone of modern immunology, including chemoreceptor and chemotherapy concepts that revolutionised blood cancer treatment over the following century. 1942 – Chemotherapy moves from trenches to treatment .