NY Times

SEPTEMBER 21, 2020

While scientists are rushing to develop an immunization for adults, no one has started the process yet for children.

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Immunization Immunity Vaccines 119

pharmaphorum

SEPTEMBER 2, 2021

A US federal judge has approved a bankruptcy settlement for Purdue Pharma that grants the Sackler family that owned the business immunity from any further civil lawsuits accusing them of contributing to opioid epidemic – to the consternation of campaigners. — Washington State Attorney General (@AGOWA) September 1, 2021.

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Immunization Immunity 105

STAT

APRIL 5, 2024

Sanofi, which is a leading supplier of the vaccine, ceased production of its IPV vaccine in December 2023, triggering concerns among health experts about an imminent supply disruption that may hobble the country’s most ambitious immunization campaign. Sanofi is believed to cater to over 80% of India’s IPV dose requirements.

Biosimilars 269

Biosimilars Vaccines Immunity Immunization 269

pharmaphorum

MARCH 4, 2021

Instead of large phase 3 trials, the MHRA will require studies showing immune responses for tweaked versions of previously approved vaccines, in line with similar guidance issued by the FDA late last month. The post Budget 2021: Sunak focuses on vaccine development to restart economy appeared first on.

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Vaccines Immunity Immunization 105

Outsourcing Pharma

JANUARY 3, 2024

Heather Stefanski joined NMDP/Be The Match in May, 2021 as vice president, medical services.

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Immunization Immunity 98

STAT

OCTOBER 24, 2024

Among the basic and life-saving medicines for which shortages continue to be problematic are Rho(D) immune globulin, pain and sedation medications, and ADHD pills. By 2021, nearly 2,000 volunteers had answered the call to test an experimental Alzheimer’s drug known as BAN2401.

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Immunity Immunization Drug Pricing Drug Development 259

Express Pharma

NOVEMBER 28, 2024

Blocking PD-1 interactions with PD-L1 and PD-L2 promotes the immune system’s ability to attack and kill tumour cells (5). Nat Med 27, 1536–1543 (2021). References Ravindranathan S, Wang X, et al. J Immunother Cancer 2023;11(Suppl 1):A1–A1731 Mai, HQ., Global Cancer Observatory: Cancer Today.

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Chemotherapy Immunity Immunization 111

pharmaphorum

NOVEMBER 15, 2021

Plus 2 add on workshops: • Elucidating the anti-tumor immunity of other immune checkpoint inhibitors in oncology. Ensure your research team secures its place at the forefront of the immune checkpoint inhibitor space by putting this event on the calendar for 2021. The post TIGIT Therapies 2021 appeared first on.

Medical Schools 52

Medical Schools Immunization Immunity Hospitals 52

PharmaShots

APRIL 25, 2023

Numerous pharmaceutical companies have developed and authorized vaccines to provide immunity against COVID-19. Despite the drenched market of covid products, many other drugs have set an impressive benchmark for pharmaceutical companies in 2021. Related Post: Top Performing Drug of 2021 - Darzalex (March Edition) Stay tuned!

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Pharmaceutical Companies Pharmaceutical Companies Vaccines Immunity 56

STAT

MARCH 6, 2023

“I’m slowly running out of options,” said Young, 62, who in November began   receiving   a five-month series of shots at a clinic near her San Francisco home; the vaccine is designed to teach her immune cells to recognize and combat tumors.

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Vaccines Bioethics Immunity Immunization 246

Drug Patent Watch

DECEMBER 9, 2024

Additionally, the immunogenicity of biosimilars, which is the ability of the drug to trigger an immune response, can be highly variable and impact the safety and efficacy of the drug. 2021, November 2). link] Lawless, L. 2016, November 11). Overcoming Challenges in the Emerging Biosimilar Landscape. link] Kurki, P., link] Algorics.

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Biosimilars Immunity Immunization 97

Express Pharma

NOVEMBER 21, 2024

Zai Lab obtained exclusive rights in January 2021 to develop and commercialise efgartigimod in Greater China* from argenx. Additionally, it is approved in the EU for gMG and in Japan for gMG and primary immune thrombocytopenia (ITP) under brand names Vyvgart and Vyvdura.

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Immunity Immunization 96

pharmaphorum

FEBRUARY 25, 2021

A nasal delivery method will also produce an immune response at the point where the virus enters the body. Altimmune’s AdCOVID is an adenovirus-vector vaccine designed to stimulate a broad immune response including both antibody and T-cell responses in the nasal cavity and respiratory tract, the point of entry for the virus.

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Vaccines Immunization Immunity 111

Express Pharma

JUNE 26, 2024

Following FDA approval in August 2021, Pfizer’s Comirnaty became the first mRNA vaccine to enter the global market, followed by Moderna’s Spikevax in January 2022. The mRNA portion of these vaccines encodes a disease-specific antigen, prompting cells to display the antigen and stimulating an immune response.

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Vaccines Immunity Immunization 111

pharmaphorum

DECEMBER 6, 2021

A trial of booster vaccinations to protect against COVID-19 has shown that the jab significantly strengthens the body’s T-cell immunity against the disease. All of these boosted immunity in younger and older people with varying efficacy. The post COVID booster shots increase immunity, trial shows appeared first on.

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Immunization Immunity Vaccines Hospitals 52

pharmaphorum

OCTOBER 17, 2022

When James P Allison and Tasuku Honjo were awarded the Nobel Prize for Medicine in 2018 for their discovery of cancer therapy through inhibition of negative immune regulation, it shone a light on decades of research into recruiting the immune system to fight cancer. That’s what makes them such a tricky detective mystery!

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Immunization Immunity Drug Development 115

pharmaphorum

JULY 27, 2022

The vaccine, codenamed BNT162b5, codes for “enhanced” prefusion spike proteins from the original wild-type strain of the virus and the Omicron variant that are designed to increase “the magnitude and breadth of the immune response.” 1 subvariant of Omicron.

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Vaccines Immunization Immunity 122

Pharmaceutical Technology

NOVEMBER 14, 2022

Such developments, including a 2021 approval of AstraZeneca’s Saphnelo (anifrolumab) , prompted The Lancet Rheumatology to posit that 2022 could be a “banner year” for the condition. In lupus, the body’s immune system starts to attack its own cells. MSCs and CAR-Ts for lupus.

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Immunity Immunization 144

Express Pharma

APRIL 7, 2023

The findings, published in the journal Environmental Health Perspectives , provide further evidence on the adverse effects of air pollution on the immune system. The team analysed data from 927 participants aged 40 to 65 years, who answered questionnaires and gave blood samples in the summer of 2020 and in the spring of 2021.

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Vaccines Immunization Immunity Diabetes 110

Pharma Marketing Network

DECEMBER 6, 2021

NEW YORK, December 6 th , 2021 (PRNEWSWIRE) – Tap Native, the leading health-focused content discovery platform, today unveiled a list of the top 20 most popular health topics viewed by consumer audiences in 2021. The Top 20 Most Popular Health Topics of 2021 are: 20. Stroke, TIA, blood clot, prevention. Hypertension.

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Diabetes Immunity Immunization Vaccines 52

BioPharma Dive

OCTOBER 10, 2024

The offering will fund testing of a potential rival to Amgen’s Tezspire and is already the sixth for an immune drug developer this year, the most since 2021.

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Immunization Immunity Drug Development 65

European Pharmaceutical Review

NOVEMBER 1, 2023

In its decision to recommend the authorisation, the EMA’s human medicines committee (CHMP) assessed laboratory data showing that the adapted vaccine is able to trigger an adequate immune response against XBB.1.5. 5, it was able to trigger a strong immune response against this strain. The most common side effects with Nuvaxovid XBB.1.5

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Vaccines Immunization Immunity 105

Express Pharma

AUGUST 23, 2023

The study was performed to understand whether the immunity gained after vaccination or a prior infection was less effective or “leaky” in situations where people are exposed to high levels of the virus.

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BioPharma Dive

OCTOBER 10, 2024

The offering will fund testing of a potential rival to Amgen’s Tezpire and is already the sixth for an immune drug developer this year, the most since 2021.

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Immunization Immunity Drug Development 61

European Pharmaceutical Review

AUGUST 2, 2023

This is an additional ingredient designed to trigger a stronger immune response. The vaccine demonstrated a strong immune response in the trial. In a clinical trial, this vaccine was shown to faciliate a strong immune response against the Omicron BA.1 1 variant, in addition to the original 2020 strain.

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Vaccines Immunization Immunity 98

European Pharmaceutical Review

NOVEMBER 25, 2022

Certain RNA methyltransferases regulate RNA sensing and innate immune activation and represent novel immune-regulatory targets. In addition, STC-15 has shown efficacy in leukaemia models via mechanisms including inhibition of leukaemia stem cell function. .”

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Immunization Immunity 98

European Pharmaceutical Review

JULY 13, 2023

The field of immunotherapy is constantly evolving with the ultimate goal to develop new treatments that help the body’s immune system fight cancer. Immune cells, such as T cells and natural killer (NK) cells, have the inherent ability to combat diseases, including cancer, but are often inhibited by the body’s own suppressive mechanisms.

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Immunization Immunity Hospitals 98

pharmaphorum

JUNE 1, 2021

Patients will also receive a dose of tacrolimus, an immune-suppressing drug, to guard against any immune reaction to the transplanted cells. — Novo Nordisk (@novonordisk) June 1, 2021. PRESS : Heartseed and Novo Nordisk enter into global collaboration and licence agreement for stem cell-based therapy for heart failure.

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Immunity Immunization Diabetes 138

European Pharmaceutical Review

NOVEMBER 24, 2022

In March 2021, the trial was halted early due to highly significant overall survival (OS) rates in squamous cell carcinoma (SCC) patients. Immune-mediated adverse reactions (ARs) occurred in 21 percent of patients treated with Libtayo ® and led to permanent discontinuation in 4.6 percent), immune-mediated hepatitis (2.4

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Chemotherapy Immunization Immunity Adverse Reactions 98

Express Pharma

OCTOBER 16, 2024

Ophelia Chan, Business Fundamentals Senior Analyst at GlobalData, comments, “The COVID-19 pandemic highlighted the key advantages of mRNA technology in vaccine development, including rapid production, precise immune targeting, and streamlined manufacturing- factors that drove the success of mRNA-based COVID-19 vaccines.”

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Vaccines Immunity Immunization Diabetes 104

pharmaphorum

SEPTEMBER 4, 2020

The French pharma in April joined forces with the UK’s GSK to produce the vaccine, with Sanofi contributing an antigen that produces the immune reaction. They are also scaling up manufacturing of the antigen and adjuvant, aiming to produce up to a billion doses in 2021.

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Vaccines Immunity Immunization 106

pharmaphorum

JANUARY 10, 2023

Other IgG proteases are being developed to tackle the issue of pre-existing immunity against AAV, but according to Selecta chief executive Carsten Brun these tend to be derived from common human pathogens – which means they themselves can be the target of existing antibodies.

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Immunity Immunization Drug Development 119

pharmaphorum

SEPTEMBER 27, 2022

The principal is much the same as in checkpoint inhibitor treatment: preventing the cancer cells from evading detection by the body’s immune system and highlighting them for destruction by T cells. The ability for cancer cells to create this suppressive tumour microenvironment (TME) allows them to avoid detection by the immune system.

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Vaccines Immunization Immunity 97

European Pharmaceutical Review

APRIL 25, 2023

R21/Matrix-M contains Novavax’s saponin-based adjuvant Matrix-M, which enhances immune response, making it more potent and more durable. Its manufacturer highlighted potential manufacturing capacities of over 200 million doses annually. How does the R21/Matrix-M vaccine work?

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Vaccines Immunity Immunization 111

pharmaphorum

DECEMBER 4, 2020

Valneva has said it plans to accelerate research into its Lyme disease vaccine candidate VLA15, bringing forward a trial including children into the first quarter of 2021. VLA15 has demonstrated a promising immune response and safety data in pre-clinical and clinical studies so far.

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Vaccines Immunity Immunization 119

pharmaphorum

MAY 10, 2021

Happy to announce that @EU_Commission has just approved a contract for guaranteed 900 million doses (+900 million options) with @BioNTech_Group @Pfizer for 2021-2023. — Ursula von der Leyen (@vonderleyen) May 8, 2021. Other contracts and other vaccine technologies will follow.

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Pharmaceutical Technology

JUNE 12, 2023

Addiction affects an estimated three million US citizens and claimed over 100,000 lives in 2021 alone. CB1 is predominantly found in the central and peripheral nervous system, whereas CB2 is primarily located in immune cells. As drug targets, these receptors have demonstrated therapeutic value against different pain varieties.

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Immunity Immunization Drug Development 143