NY Times

SEPTEMBER 21, 2020

While scientists are rushing to develop an immunization for adults, no one has started the process yet for children.

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Immunity Immunization Vaccines 119

Outsourcing Pharma

JANUARY 3, 2024

Heather Stefanski joined NMDP/Be The Match in May, 2021 as vice president, medical services.

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Immunity Immunization 98

STAT

APRIL 5, 2024

Sanofi, which is a leading supplier of the vaccine, ceased production of its IPV vaccine in December 2023, triggering concerns among health experts about an imminent supply disruption that may hobble the country’s most ambitious immunization campaign. Sanofi is believed to cater to over 80% of India’s IPV dose requirements.

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Biosimilars Vaccines Immunity Immunization 275

STAT

OCTOBER 24, 2024

Among the basic and life-saving medicines for which shortages continue to be problematic are Rho(D) immune globulin, pain and sedation medications, and ADHD pills. By 2021, nearly 2,000 volunteers had answered the call to test an experimental Alzheimer’s drug known as BAN2401.

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Immunity Immunization Drug Pricing Drug Development 262

Express Pharma

NOVEMBER 28, 2024

Blocking PD-1 interactions with PD-L1 and PD-L2 promotes the immune system’s ability to attack and kill tumour cells (5). Nat Med 27, 1536–1543 (2021). References Ravindranathan S, Wang X, et al. J Immunother Cancer 2023;11(Suppl 1):A1–A1731 Mai, HQ., Global Cancer Observatory: Cancer Today.

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pharmaphorum

FEBRUARY 24, 2021

2021 will be the year when big market access changes – including the far wider use of health economic evaluation – are implemented in Spain. In the latest of a suite of features looking at the biggest markets in Europe, Leela Barham takes stock of what 2021 could bring for market access in Spain. Higher biosimilar savings.

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Biosimilars Immunity Immunization 100

pharmaphorum

DECEMBER 6, 2021

A trial of booster vaccinations to protect against COVID-19 has shown that the jab significantly strengthens the body’s T-cell immunity against the disease. All of these boosted immunity in younger and older people with varying efficacy. The post COVID booster shots increase immunity, trial shows appeared first on.

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Immunity Immunization Vaccines Hospitals 52

pharmaphorum

MARCH 4, 2021

Instead of large phase 3 trials, the MHRA will require studies showing immune responses for tweaked versions of previously approved vaccines, in line with similar guidance issued by the FDA late last month. The post Budget 2021: Sunak focuses on vaccine development to restart economy appeared first on.

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Vaccines Immunity Immunization 105

pharmaphorum

FEBRUARY 25, 2021

A nasal delivery method will also produce an immune response at the point where the virus enters the body. Altimmune’s AdCOVID is an adenovirus-vector vaccine designed to stimulate a broad immune response including both antibody and T-cell responses in the nasal cavity and respiratory tract, the point of entry for the virus.

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Vaccines Immunity Immunization 111

Drug Patent Watch

DECEMBER 9, 2024

Additionally, the immunogenicity of biosimilars, which is the ability of the drug to trigger an immune response, can be highly variable and impact the safety and efficacy of the drug. 2021, November 2). link] Lawless, L. 2016, November 11). Overcoming Challenges in the Emerging Biosimilar Landscape. link] Kurki, P., link] Algorics.

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pharmaphorum

OCTOBER 17, 2022

When James P Allison and Tasuku Honjo were awarded the Nobel Prize for Medicine in 2018 for their discovery of cancer therapy through inhibition of negative immune regulation, it shone a light on decades of research into recruiting the immune system to fight cancer. That’s what makes them such a tricky detective mystery!

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Immunity Immunization Drug Development 115

STAT

MARCH 6, 2023

“I’m slowly running out of options,” said Young, 62, who in November began   receiving   a five-month series of shots at a clinic near her San Francisco home; the vaccine is designed to teach her immune cells to recognize and combat tumors.

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Express Pharma

NOVEMBER 21, 2024

Zai Lab obtained exclusive rights in January 2021 to develop and commercialise efgartigimod in Greater China* from argenx. Additionally, it is approved in the EU for gMG and in Japan for gMG and primary immune thrombocytopenia (ITP) under brand names Vyvgart and Vyvdura.

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Immunity Immunization 96

pharmaphorum

NOVEMBER 15, 2021

Plus 2 add on workshops: • Elucidating the anti-tumor immunity of other immune checkpoint inhibitors in oncology. Ensure your research team secures its place at the forefront of the immune checkpoint inhibitor space by putting this event on the calendar for 2021. The post TIGIT Therapies 2021 appeared first on.

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Medical Schools Immunity Immunization Hospitals 52

Express Pharma

APRIL 7, 2023

The findings, published in the journal Environmental Health Perspectives , provide further evidence on the adverse effects of air pollution on the immune system. The team analysed data from 927 participants aged 40 to 65 years, who answered questionnaires and gave blood samples in the summer of 2020 and in the spring of 2021.

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Vaccines Immunity Immunization Diabetes 110

Express Pharma

AUGUST 23, 2023

The study was performed to understand whether the immunity gained after vaccination or a prior infection was less effective or “leaky” in situations where people are exposed to high levels of the virus.

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pharmaphorum

JULY 27, 2022

The vaccine, codenamed BNT162b5, codes for “enhanced” prefusion spike proteins from the original wild-type strain of the virus and the Omicron variant that are designed to increase “the magnitude and breadth of the immune response.” 1 subvariant of Omicron.

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European Pharmaceutical Review

JULY 13, 2023

The field of immunotherapy is constantly evolving with the ultimate goal to develop new treatments that help the body’s immune system fight cancer. Immune cells, such as T cells and natural killer (NK) cells, have the inherent ability to combat diseases, including cancer, but are often inhibited by the body’s own suppressive mechanisms.

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Immunity Immunization Hospitals 98

European Pharmaceutical Review

NOVEMBER 24, 2022

In March 2021, the trial was halted early due to highly significant overall survival (OS) rates in squamous cell carcinoma (SCC) patients. Immune-mediated adverse reactions (ARs) occurred in 21 percent of patients treated with Libtayo ® and led to permanent discontinuation in 4.6 percent), immune-mediated hepatitis (2.4

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Pharmaceutical Technology

NOVEMBER 14, 2022

Such developments, including a 2021 approval of AstraZeneca’s Saphnelo (anifrolumab) , prompted The Lancet Rheumatology to posit that 2022 could be a “banner year” for the condition. In lupus, the body’s immune system starts to attack its own cells. MSCs and CAR-Ts for lupus.

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Immunity Immunization 144

European Pharmaceutical Review

NOVEMBER 1, 2023

In its decision to recommend the authorisation, the EMA’s human medicines committee (CHMP) assessed laboratory data showing that the adapted vaccine is able to trigger an adequate immune response against XBB.1.5. 5, it was able to trigger a strong immune response against this strain. The most common side effects with Nuvaxovid XBB.1.5

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European Pharmaceutical Review

AUGUST 2, 2023

This is an additional ingredient designed to trigger a stronger immune response. The vaccine demonstrated a strong immune response in the trial. In a clinical trial, this vaccine was shown to faciliate a strong immune response against the Omicron BA.1 1 variant, in addition to the original 2020 strain.

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Vaccines Immunity Immunization 98

European Pharmaceutical Review

NOVEMBER 25, 2022

Certain RNA methyltransferases regulate RNA sensing and innate immune activation and represent novel immune-regulatory targets. In addition, STC-15 has shown efficacy in leukaemia models via mechanisms including inhibition of leukaemia stem cell function. .”

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Immunity Immunization 98

pharmaphorum

SEPTEMBER 27, 2022

The principal is much the same as in checkpoint inhibitor treatment: preventing the cancer cells from evading detection by the body’s immune system and highlighting them for destruction by T cells. The ability for cancer cells to create this suppressive tumour microenvironment (TME) allows them to avoid detection by the immune system.

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Vaccines Immunity Immunization 97

PharmaShots

APRIL 25, 2023

Numerous pharmaceutical companies have developed and authorized vaccines to provide immunity against COVID-19. Despite the drenched market of covid products, many other drugs have set an impressive benchmark for pharmaceutical companies in 2021. Related Post: Top Performing Drug of 2021 - Darzalex (March Edition) Stay tuned!

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Pharmaceutical Companies Pharmaceutical Companies Vaccines Immunity 56

Express Pharma

JUNE 26, 2024

Following FDA approval in August 2021, Pfizer’s Comirnaty became the first mRNA vaccine to enter the global market, followed by Moderna’s Spikevax in January 2022. The mRNA portion of these vaccines encodes a disease-specific antigen, prompting cells to display the antigen and stimulating an immune response.

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pharmaphorum

JUNE 1, 2021

Patients will also receive a dose of tacrolimus, an immune-suppressing drug, to guard against any immune reaction to the transplanted cells. — Novo Nordisk (@novonordisk) June 1, 2021. PRESS : Heartseed and Novo Nordisk enter into global collaboration and licence agreement for stem cell-based therapy for heart failure.

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Immunity Immunization Diabetes 138

BioPharma Dive

OCTOBER 10, 2024

The offering will fund testing of a potential rival to Amgen’s Tezspire and is already the sixth for an immune drug developer this year, the most since 2021.

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Immunity Immunization Drug Development 64

pharmaphorum

APRIL 9, 2021

Founded in 1999, Marseille-based company Innate Pharma is on a mission to develop immunotherapies that take advantage of the body’s innate immune system. The cytokine release prompts T-cells so they can translate that first innate immune response into a long-lasting adaptive immune response. About the interviewee.

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Immunity Immunization Packaging 122

Express Pharma

OCTOBER 16, 2024

Ophelia Chan, Business Fundamentals Senior Analyst at GlobalData, comments, “The COVID-19 pandemic highlighted the key advantages of mRNA technology in vaccine development, including rapid production, precise immune targeting, and streamlined manufacturing- factors that drove the success of mRNA-based COVID-19 vaccines.”

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Vaccines Immunity Immunization Diabetes 104

FDA Law Blog: Biosimilars

APRIL 30, 2023

Senate Committee on Health, Education, Labor and Pensions (“Senate HELP”) is scheduled to take up legislation that could significantly limit access to the courts and immunize critical FDA decisions from timely judicial review. And in December 2021, we saw FDA apply those factors in responding to a citizen petition (Docket No.

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Immunity Immunization Biosimilars Labelling 59

BioPharma Dive

OCTOBER 10, 2024

The offering will fund testing of a potential rival to Amgen’s Tezpire and is already the sixth for an immune drug developer this year, the most since 2021.

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Immunity Immunization Drug Development 60

pharmaphorum

JANUARY 10, 2023

Other IgG proteases are being developed to tackle the issue of pre-existing immunity against AAV, but according to Selecta chief executive Carsten Brun these tend to be derived from common human pathogens – which means they themselves can be the target of existing antibodies.

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Immunity Immunization Drug Development 119

European Pharmaceutical Review

JULY 13, 2022

Our work is establishing whether it is possible to use allogeneic innate immune cells from a healthy donor to support the immune system of a person with cancer in combatting the condition. T cells are the first line of defence in the immune system to eradicate diseases. such as a chimeric antigen receptor (CAR). In response, ??

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Immunity Immunization Chemotherapy 97

pharmaphorum

SEPTEMBER 22, 2022

When exposed to a virus, one’s immune system develops antibodies in response to foreign antigens, with or without a vaccine. However, a vaccine trains the immune system to recognise that familiar virus and kill it more rapidly. Osivax’s technology, oligoDOM, trains the T-cell immune response to recognise the nucleoprotein.

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Vaccines Immunity Immunization 97

European Pharmaceutical Review

JULY 12, 2022

By binding to both CD19, an antigen expressed on B-cells, and to the CD3 receptor on T-cells, TNB-486 activates and recruits T-cells to CD19-expressing tumours where they can elicit an immune response. “By

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Immunity Immunization Chemotherapy 98

pharmaphorum

NOVEMBER 28, 2021

— Sajid Javid (@sajidjavid) November 27, 2021. BioNTech said in a statement that it is waiting on more data from lab tests, due in the next couple of weeks, to see if Omicron could be an “escape variant” – a strain of SARS-CoV-2 that could evade the immune responses stimulated by current vaccines.

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