ALiEM - Pharm Pearls

OCTOBER 21, 2024

A 5-year-old generally healthy fully immunized boy presented to the ED with worsening left ear redness, swelling, and tenderness that his family noticed the day before presentation. 2019 Aug;276(8):2199-2203. Epub 2019 May 11. His family had also recently noticed an abrasion over that ear. Klug TE, Holm N, Greve T, Ovesen T.

Medical Schools 169

Medical Schools Immunity Immunization 169

NY Times

FEBRUARY 28, 2021

The company’s coming trials will also involve pregnant women and people whose immune systems are compromised.

Immunization 144

Immunization Immunity Vaccines 144

NY Times

APRIL 15, 2021

Many cannot produce enough infection-fighting cells to fend off the coronavirus. But researchers are testing one therapy that may help: monoclonal antibodies.

Immunity 98

Immunity Immunization Vaccines 98

NY Times

DECEMBER 8, 2021

The antibody drug, Evusheld, was found to be strongly effective in preventing Covid in a clinical trial that enrolled mostly those at high risk.

Immunity 95

Immunity Immunization 95

European Pharmaceutical Review

AUGUST 10, 2022

The deal includes MiroBio’s proprietary I-ReSToRE ( RE ceptor S election and T argeting t o R einstate immune E quilibrium) discovery platform and its entire portfolio of immune inhibitory receptor agonists. MB272 targets T, B and dendritic cells to inhibit or blunt activation and suppress an inflammatory immune response. . “We

Immunity 98

Immunity Immunization 98

European Pharmaceutical Review

MARCH 19, 2024

This pathway works in the innate immune system to sense cytosolic DNA by triggering a STING-dependent inflammatory response. In September 2019, IFM Due entered into an option and collaboration agreement with Novartis, who agreed to finance IFM Due’s research and development costs for the cGAS-STING programme.

Immunity 105

Immunity Immunization 105

NY Times

FEBRUARY 9, 2022

It’s not clear whether three doses of the Pfizer-BioNTech vaccine will adequately protect young children. But the F.D.A. may authorize the first two doses anyway.

Vaccines 78

Vaccines Immunity Immunization 78

pharmaphorum

AUGUST 5, 2022

MiroBio was formed in 2019 to develop checkpoint agonist antibodies for autoimmune and inflammatory disorders that can be used to apply the “natural brakes” of the immune system. 7 integrin, with three candidates in early-stage clinical development.

Immunity 105

Immunity Immunization Drug Development 105

pharmaphorum

JANUARY 18, 2021

Quadri, formerly Merck’s head of medical and scientific affairs, immune oncology, has been charged with one count of theft of trade secrets and one count of unauthorised transmission of trade secrets, some relating to the multi-billion dollar cancer immunotherapy Keytruda (pembrolizumab).

Documentation 95

Documentation Immunity Immunization Pharmaceutical Companies 95

pharmaphorum

JULY 6, 2021

While these types of tests are important, they don’t tell the whole story, as they can’t provide information on whether an individual has built an immune response to COVID-19, either through vaccination or through a previous infection. This is where antibody tests come in. ” . . The Importance of Antibody Certificates.

Immunity 111

Immunity Immunization Vaccines 111

European Pharmaceutical Review

DECEMBER 12, 2023

He discusses why NK cell therapy’s ability to generate ‘synthetic immunity’ in the body means this modality holds potential as an anti-cancer treatment. We specialise in the development of new cutting-edge immunotherapies , based on the use of therapeutic antibodies capable of activating the immune system to fight cancer.

Immunity 124

Immunity Immunization Chemotherapy Pharmaceutical Companies 124

NY Times

DECEMBER 18, 2020

The Food and Drug Administration authorized a second coronavirus vaccine for emergency use, clearing the way for millions more Americans to be immunized next week.

Vaccines 105

Vaccines Immunity Immunization Nursing Homes 105

European Pharmaceutical Review

AUGUST 2, 2023

This is an additional ingredient designed to trigger a stronger immune response. The vaccine demonstrated a strong immune response in the trial. In a clinical trial, this vaccine was shown to faciliate a strong immune response against the Omicron BA.1 1 variant, in addition to the original 2020 strain.

Vaccines 98

Vaccines Immunity Immunization 98

European Pharmaceutical Review

MAY 17, 2023

The viral therapy “aims to awaken the patient’s immune system and trigger a healing from within,” Dr Fueyo commented. After injection, patients that respond well develop inflammation inside the tumour, triggering an immune response that first kills the virus.” This makes it difficult to treat the cancer with immunotherapy.

Immunity 98

Immunity Immunization Chemotherapy 98

NY Times

DECEMBER 30, 2021

Regulators will also allow even younger children with immune deficiencies to get an extra shot.

Immunity 98

Immunity Immunization Vaccines 98

pharmaphorum

JANUARY 10, 2023

Since then, the two partners have developed multiple AI-based applications including a platform for selecting neoantigens for use in individualised cancer vaccines and an early warning system for high risk SARS-CoV-2 variants based on how well they can evade the immune system and their transmissibility.

Immunity 116

Immunity Immunization Vaccines 116

pharmaphorum

JUNE 16, 2022

The result isn’t a big surprise – Roche terminated two phase 3 trials of crenezumab in people with prodromal to mild sporadic Alzheimer’s in early 2019 after interim analyses found it would be futile to continue – but is another blow to the amyloid hypothesis.

Immunity 111

Immunity Immunization 111

Express Pharma

OCTOBER 16, 2024

Messenger ribonucleic acid (mRNA)-based innovator pharmaceuticals saw a staggering 800 per cent increase in licensing agreement deal values from 2019 to 2024YTD, driven by the remarkable success of mRNA vaccines during the COVID-19 pandemic. Bristol Myers Squibb formed a multi-year, $1.87

Vaccines 102

Vaccines Immunity Immunization Diabetes 102

Express Pharma

JULY 19, 2023

million children missed out on one or more vaccines delivered through routine immunization services, compared to 24.4 million children who missed out in 2019 before pandemic-related disruptions, underscoring the need for ongoing catch-up, recovery and system strengthening efforts. million children in 2019.

Vaccines 96

Vaccines Immunity Immunization Communication 96

pharmaphorum

APRIL 28, 2021

Between just February and May 2020, submissions to Elsevier’s journals alone went up by 58% compared to the same period in 2019. “Text mining was also able to highlight new insights into the mechanisms of pancreatic cancer’s immune evasion, which refers to cancer cells’ ability to evade an immune response” .

Immunity 105

Immunity Immunization 105

NY Times

MARCH 23, 2022

The company said the vaccine produced a strong immune response in children younger than 6, but proved only about 40 percent effective in preventing symptomatic Covid-19.

Vaccines 94

Vaccines Immunity Immunization 94

pharmaphorum

JUNE 15, 2022

Cytokines have long been investigated for their potential as cancer treatments – selectively stimulate tumour-fighting immune cells – with varying levels of success. The company came to Boehringer’s attention in 2019, when it took part in the drugmaker’s BI Innovation Prize competition.

Immunity 98

Immunity Immunization Vaccines 98

pharmaphorum

JUNE 21, 2021

It would be easy to forget that back in 2019, BioNTech was an early-stage biotech firmly focused on cancer vaccines, before being catapulted onto the world-stage with its COVID-19 shot.

Vaccines 145

Vaccines Immunity Immunization 145

European Pharmaceutical Review

NOVEMBER 18, 2022

This is almost three times the 2019 market volume (5.8 billion), nearly three-and-a-half times the 2019 market value ($38 billion). Achieving Immunization Agenda 2030 goals. The document showed that in 2021, approximately 16 billion vaccine doses, worth $141 billion, were supplied across 47 vaccines and 94 manufacturers.

Vaccines 98

Vaccines Immunity Immunization Documentation 98

European Pharmaceutical Review

JULY 13, 2023

The field of immunotherapy is constantly evolving with the ultimate goal to develop new treatments that help the body’s immune system fight cancer. Immune cells, such as T cells and natural killer (NK) cells, have the inherent ability to combat diseases, including cancer, but are often inhibited by the body’s own suppressive mechanisms.

Immunity 98

Immunity Immunization Hospitals 98

Express Pharma

FEBRUARY 22, 2024

Takeda entered into multiple cell therapy collaborations for the development of CAR-T therapies with organisations like Memorial Sloan Kettering Cancer Center (MSK), Noile-Immune Biotech, and Crescendo Biologics in 2019 to advance the company’s novel immuno-oncology portfolio.

Immunity 105

Immunity Immunization 105

European Pharmaceutical Review

JULY 12, 2022

By binding to both CD19, an antigen expressed on B-cells, and to the CD3 receptor on T-cells, TNB-486 activates and recruits T-cells to CD19-expressing tumours where they can elicit an immune response. “By The post AstraZeneca to acquire TeneoTwo and its blood-cancer therapeutic appeared first on European Pharmaceutical Review.

Immunity 98

Immunity Immunization Chemotherapy 98

pharmaphorum

APRIL 8, 2022

Once within the tumour, it stimulates receptors on immune cells to mount an attack on the cancer. It was launched as Intron A by Schering-Plough (now Merck & Co) in the 1980s before being discontinued by the company in 2019 based on evaluation of its clinical activity and the emergence of alternative therapies.

Immunity 105

Immunity Immunization 105

NY Times

MARCH 29, 2022

Those 12 and older with certain immune deficiencies are also eligible. People in the age group can get the additional shot at least four months after their first booster.

Immunity 87

Immunity Immunization Vaccines 87

STAT

MARCH 6, 2023

“I’m slowly running out of options,” said Young, 62, who in November began   receiving   a five-month series of shots at a clinic near her San Francisco home; the vaccine is designed to teach her immune cells to recognize and combat tumors.

Vaccines 246

Vaccines Bioethics Immunity Immunization 246

ALiEM - Pharm Pearls

MARCH 29, 2023

2019 Mar; 2(3). Biondi EA, Lee B, Ralston SL, et al. Prevalence of Bacteremia and Bacterial Meningitis in Febrile Neonates and Infants in the Second Month of Life: A Systematic Review and Meta-analysis. JAMA Network Open. PMID: 30901044. Baker MD, Avner JR, Bell LM. Pediatrics. 1990;85(6):1040–1043.

Hospitals 360

Hospitals Documentation Inpatient Immunity 360

pharmaphorum

MARCH 11, 2021

VX-880 (formerly known as STx-02) derives from Vertex’ near $1 billion acquisition of Semma in 2019, and has started enrolling patients in a phase 1/2 study in the US. As this won’t be used in the initial phase 1/2 trial, patients will have to receive immunosuppressive drugs to dampen down the immune response.

Diabetes 98

Diabetes Immunity Immunization 98

pharmaphorum

MARCH 9, 2021

SARS-CoV-2 is likely to stay endemic in the human population for the foreseeable future, ExeVir noted, with variants capable of evading immunity the most likely cause of the disease in the future as global vaccination programmes begin to take effect. Ablynx, which is now a subsidiary of Sanofi following a $4.8

Immunity 98

Immunity Immunization Vaccines 98

NY Times

MAY 11, 2022

Antibody levels rose in the children who received it, suggesting the vaccine protects against infection. But the data were gathered before the arrival of Omicron.

Vaccines 62

Vaccines Immunity Immunization 62

STAT

JULY 24, 2023

Breast cancer has also shown an  accelerating increase  among women under 50, rising only slightly from 2000 to 2015 but increasing by 2 percent a year from 2015 to 2019. percent a year from 2017 to 2019; the yearly increase among women was 2.4 percent from 2000 to 2019.

Medical Schools 246

Medical Schools Hospitals Chemotherapy Immunization 246

pharmaphorum

AUGUST 31, 2022

Kaiku’s DPPM platform has also attracted the attention of other big pharma groups, including Roche which has been working with the company since 2019 on personalised support modules for patients taking its PD-L1 inhibitor Tecentriq (atezolizumab).

Chemotherapy 116

Chemotherapy Immunity Immunization Hospitals 116

European Pharmaceutical Review

APRIL 25, 2023

This signals the cell to the immune system and so it targets and kills the myeloma cell. A promising treatment for myeloma DVD was first rolled out in 2019 after it was approved through the Cancer Drugs Fund.

Immunity 98

Immunity Immunization 98