European Pharmaceutical Review

JANUARY 26, 2024

It is a key component of human vaccines for shingles, malaria, coronavirus disease 2019 and others under development.” Bioengineering vaccine adjuvants The paper explained: “QS-21 is a potent vaccine adjuvant currently sourced by extraction from the Chilean soapbark tree. Martin et al. Martin et al.

Vaccines 98

Vaccines Compounding Immunity Immunization 98

ALiEM - Pharm Pearls

NOVEMBER 1, 2023

 Deferoxamine binds with ferric iron (Fe3+) to form ferrioxamine, a water-soluble compound excreted in the urine. As McGraw-Hill Education; 2019 Madiwale T, Liebelt E. Iron toxicity treated with deferoxamine Background Deferoxamine is the treatment for severe iron toxicity [1]. Deferoxamine Blake Froberg, Bryan Judge, and Louise Kao.

Clinical Pharmacology 161

Clinical Pharmacology Dosage Compounding 161

pharmaphorum

NOVEMBER 12, 2020

The company was founded as a spin-off of the University of Bern and Swiss research institute NCCR TransCure in April 2019, and is focused on the development of a new class of drugs that work on endocannabinoids, a type of neurotransmitter that bind to the receptors in the brain targeted by cannabinoid compounds.

Drug Development 106

Drug Development Compounding 106

pharmaphorum

NOVEMBER 24, 2020

The blank cheque company or ‘special purpose acquisition company’ (SPAC) that provides funding is GigCapital2, which raised $150 million in its public offering in June 2019. The merger is expected to be completed in the first quarter of 2021, subject to the usual closing conditions.

Packaging 138

Packaging Compounding 138

Pharmaceutical Technology

SEPTEMBER 9, 2022

Initially, the companies partnered to identify new targets for respiratory and cardiovascular diseases using Gatehouse Bio’s artificial intelligence (AI)-powered platform in December 2019. It is expected to expedite the development of a wide range of new therapeutics using the small non-coding area of the genome that is not explored.

Compounding 98

Compounding 98

pharmaphorum

FEBRUARY 3, 2022

It said the medical cannabis market in Germany is valued at approximately €122 million, growing at around 25% last year and with a compound annual growth rate estimated at 55 % since the market was liberalised in 2017.

Compounding 119

Compounding 119

pharmaphorum

AUGUST 17, 2022

The deal will see Atomwise identify, synthesize, and advance lead compounds for up to five drug targets that will then be exclusively Sanofi’s to develop. In 2019 they struck a major deal with China’s Hansoh pharmaceuticals. “At Additional payments will be tied to specific research, development, and sales milestones.

Compounding 97

Compounding Drug Development 97

RX Note

MARCH 23, 2023

Today, stability information can be obtained from manufacturer’s labelling information (such as in the package insert), the USP compounding monographs, or peer-reviewed articles and references , such as articles in American Journal of Health-System Pharmacy, the International Journal of Pharmaceutical Compounding.

Compounding 52

Compounding Sterile Compounds Packaging Labelling 52

pharmaphorum

JUNE 27, 2022

billion takeover of Clementia Pharma in 2019 – and erosion of its sales for top-selling acromegaly and neuroendocrine tumour therapy Somatuline (lanreotide). “Furthermore, we are excited to bring on board epigenetic expertise and the SETD2 inhibitor, as well as several preclinical compounds into our portfolio.”

Compounding 110

Compounding 110

pharmaphorum

JULY 21, 2021

In 2019, a team at Massachusetts Institute of Technology (MIT) in the US came up with just such a model, and found that it was able to perform “better than random” at predicting the outcome of a clinical trial or development programme. The results were interesting, but the team wanted to do better.

Data Entry 105

Data Entry Drug Development Compounding 105

European Pharmaceutical Review

OCTOBER 23, 2023

In most cases, formulation compounds represent a fixed starting point from which any changes can be implemented, whereas tableting process parameters as well as machine condition, can be managed and optimised to their best, combining the knowledge of the machine manufacturer with the experience of the pharmaceutical industry. Sugar Alcohols.

Compounding 98

Compounding Pharmaceutical Manufacturing 98

European Pharmaceutical Review

AUGUST 17, 2022

billion by 2030, expanding at a compound annual growth rate (CAGR) of 7.2 For Biogen, this was a 75 percent increase in R&D expenditure from 2019. According to a recent report , the global formulation development outsourcing market size should grow to $61.4 percent from its 2022 value of $35.1

Compounding 96

Compounding Pharmaceutical Companies Pharmaceutical Companies Drug Development 96

The Thyroid Pharmacist

JUNE 30, 2023

Interview With Dr. Mark Mandel To learn more, I decided to interview Dr. Mark Mandel, PharmD, compounding pharmacist, LDN expert, and fellow Midwestern University Chicago College of Pharmacy grad, on the effects of LDN in people with Hashimoto’s and autoimmunity. The transdermal formulation is recommended for children with autism.

Compounding 98

Compounding Immunity Immunization Compounding Pharmacies 98

European Pharmaceutical Review

DECEMBER 13, 2022

2 The issue arose because sulfanilamide is an extremely bitter tasting drug and to taste-mask the elixir formulation for use in children, the compounding pharmacist used EG as it was a good solvent, sweet-tasting and cheap. 5 Both compounds are limited to ≤0.1 percent or 1,000 ppm. This is considered an essentially safe dose.

Compounding 105

Compounding Packaging 105

RX Note

JANUARY 21, 2023

Adverse Drug Reaction Drug Induced Diseases, 2018 Meyler's Side Effects of Drugs, 2015 Antibiotics The Sanford Guide to Antimicrobial Therapy, 2022 Breastfeeding Briggs' Drugs in Pregnancy and Lactation, 2021 Hale's Medications and Mothers' Milk, 2021 Clinical Practice Applied Therapeutics, 2018 Conn’s Current Therapy, 2022 Current Medical Diagnosis (..)

Compounding 40

Compounding Community Pharmacies Clinical Pharmacology Dosage 40

pharmaphorum

JULY 16, 2021

Galapagos has had to send its SIK inhibitor programme back to the drawing board after its lead compound GLPG3970 has failed two of three clinical trials, adding to a string of disappointments for the Belgian biotech. . The preclinical compounds are expected to move into the human testing stage next year.

Mayo Clinic 59

Mayo Clinic Compounding 59

European Pharmaceutical Review

OCTOBER 19, 2023

With alpha particles, you must be very careful how the drug is made to ensure that the compound remains stable between manufacturing and use. Dr Hoppin began working with Dr John Babich and Noria Therapeutics in 2018, joining their board of directors in 2019 and supporting the subsequent creation and funding of subsidiary PSMA Therapeutics.

Chemotherapy 105

Chemotherapy Compounding Immunity Immunization 105

Pharmaceutical Business Review

AUGUST 31, 2023

A small molecular compound and a novel type of calcimimetics discovered by Mitsubishi Tanabe Pharma Corporation, Orkedia Tablets suppresses parathyroid hormone (PTH) secretion as it acts on the calcium receptors on parathyroid gland cells.

Dosage 52

Dosage Compounding 52

Pharmaceutical Technology

SEPTEMBER 15, 2022

According to GlobalData’s report, Coronavirus Disease 2019 (Covid-19) Analyst Consensus Sales Analysis and Forecast, H1 2022 , Comirnaty is the leading prophylactic Covid-19 vaccine and recorded sales of $41.3bn in 2021.

Vaccines 108

Vaccines Drug Pricing Biosimilars Documentation 108

pharmaphorum

JUNE 7, 2022

The Hong Kong-based startup – one of an emerging crop of companies which are using artificial intelligence platforms to discover and design new therapeutic compounds – took its first drug into clinical trials in February.

Compounding 52

Compounding 52

RX Note

MARCH 23, 2023

Introduction Despite the shifting of pharmacy focus to pharmaceutical care, the practice of compounding pharmaceutical formulations remains an essential skill for pharmacists. Ora-Blend Ora-Blend is a flavoured oral suspending vehicle used to simplify the process involved in the extemporaneous compounding of oral suspensions.

Compounding 52

Compounding Health and Personal Care Stores Hospitals Dosage 52

Eye on FDA

AUGUST 2, 2022

The characterization of investigative data resulted in a violation related to promotion of an unapproved compound. Correspondingly, the instances of promotion of an unapproved use has diminished and was last named as a violation in 2019.

Communication 88

Communication Pharmaceutical Companies Pharmaceutical Companies Documentation 88

pharmaphorum

MAY 11, 2021

Healthcare systems the world over have been facing the same challenges for some time – and the pandemic has only served to compound them. The NHS AI Lab, set up in 2019 in partnership with the Accelerated Access Collaborative, was designed to change that. Embracing AI potential.

Compounding 119

Compounding Hospitals 119

pharmaphorum

DECEMBER 21, 2022

The GLP-1 agonist was the first drug in the partnership – which spans multiple compounds and therapeutic categories – to be selected for clinical development in 2019. For now, Rybelsus will be in Pfizer and Sosei Heptares’ sights, but there’s no word from them yet on why PF-07081532 could offer an improved profile.

Diabetes 52

Diabetes Compounding 52

European Pharmaceutical Review

JUNE 24, 2022

The review was impacted by Brexit and the COVID-19 pandemic, which compounded existing issues surrounding high drug pricing and patient access that had been brewing since 2016 and highlighted several shortcomings in the EU’s pharmaceutical system. Amsterdam: Gupta Strategists; 2019. Available from: [link].

Compounding 105

Compounding Drug Development Drug Pricing Dosage 105

pharmaphorum

OCTOBER 10, 2022

The global digital health market is expected to make a compound annual growth rate of almost 25% from 2019 to 2025. Although the health technology industry is experiencing a funding lull right now, the current climate won’t last forever.

Compounding 111

Compounding Hospitals 111

PharmD Live

MAY 13, 2024

These guidelines are often based on the best available evidence for treating individual diseases but may not fully consider the implications of multimorbidity (American Geriatrics Society, 2019). “Medication Management in Long-Term Care,” Clinical Interventions in Aging , 2019). Reference: Jones, R.

Long-Term Care Facilities 105

Long-Term Care Facilities Diabetes Nursing Homes Prescription Filling 105

pharmaphorum

NOVEMBER 24, 2022

Dr Catherine Kettleborough, lead of the LifeArc Chronic Respiratory Infection Translational Challenge, said: “Repurposing an existing drug or compound is a faster way of getting new treatments to patients. In 2019, the charity received a windfall of nearly $1.3 Travel to hospital for regular check-ups is frequently needed.

Hospitals 59

Hospitals Compounding Drug Development 59

pharmaphorum

JANUARY 8, 2021

According to the figures compiled in the third quarter of last year, pharma brands were projected to spend around $10 billion in 2020 on digital advertising aimed at all groups including doctors, a compound annual growth rate of more than 13% since 2014. compared with 2019, and the digital spend is forecast to increase to $11.25

Communication 98

Communication Compounding 98

Eye on FDA

JULY 5, 2022

by mid-year 2019, there were only 13 approvals of new entities but the year netted out with a respectable 48. But one could also surmise that AdComms are reserved for circumstances where FDA wants outside counsel because an investigative compound is exploring new territory.

Compounding 81

Compounding 81

pharmaphorum

AUGUST 31, 2021

His departure comes after a tricky period for Galapagos, which van de Stolpe alludes to in his retirement announcement, saying: “despite recent setbacks, we continue to progress a deep pipeline of novel target-based compounds, while the commercial roll-out of our first approved product is underway.”

Compounding 52

Compounding 52

pharmaphorum

APRIL 10, 2022

10,808,039) covering ADCs that include auristatin compounds coupled to an antibody via a linker molecule. billion licensing deal for the drug in 2019. Seagen claims Enhertu (trastuzumab deruxtecan) – an antibody-drug conjugate (ADC) targeting HER2 – infringes a patient it holds (No.

Compounding 52

Compounding 52

Pharmaceutical Technology

JUNE 15, 2023

The deal gives Astellas the option to exclusively license its rights for clinical development and commercialisation for any protein degrader compounds developed within the lead programme. Since 2019, the company has raised $106m in three financing rounds to push the development of its uSMITE platform.

Compounding 52

Compounding 52

pharmaphorum

MAY 14, 2021

In 2019, the biopharma teamed up with Skyhawk Therapeutics to try to find small-molecule drugs that could modulate RNA splicing, focusing on candidates for neurological disorders like multiple sclerosis and SMA. It’s not the first partnership for Biogen in the RNA splicing area.

Compounding 60

Compounding 60

pharmaphorum

SEPTEMBER 30, 2020

The first closed in late 2019, involving Chardan Healthcare Acquisition and BiomX, a microbiome specialist, and since then five others have been announced, including Vesper Healthcare Acquisition which was unveiled earlier this month and is being led by former Allergan chief executive Brent Saunders.

Compounding 64

Compounding 64

European Pharmaceutical Review

FEBRUARY 21, 2023

As well as having potential in helping to treat conditions such as chronic pain, developments in the field show the compound could help treat a wider variety of conditions. Advising companies, he emphasised that those “manufacturing cannabis-based medicines should not underestimate the scale of the challenge.”

Pharmaceutical Companies 132

Pharmaceutical Companies Pharmaceutical Companies Compounding Drug Development 132

Pharmaceutical Technology

JANUARY 23, 2023

In addition to Skyrizi’s recent supplementary CD indication, both Tremfya and Skyrizi received US FDA approval in psoriasis in 2017 and in 2019, respectively. These developments were compounded by Lilly’s announcement that it has discontinued development of mirikizumab for psoriasis in April of last year.

Labelling 59

Labelling Compounding Drug Development 59