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Chickenpox

RX Note

NOTE: Chickenpox typically presents in children. Use varicella zoster immune globulin (VariZIG) as postexposure prophylaxis in immunocompromised patients, pregnant women, premature infants, and neonates born to mothers with evidence of infection if able to give within 96 hours of exposure to varicella (preferably within 48 hours).

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NICE recommends first CAR-T cell therapy on NHS in England

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More specifically, CAR-T cell therapy engineers a patient’s own immune cells (T-cells) to detect, target, and destroy cancer cells. In 2018, England was the first country in Europe to provide access to a CAR-T cell therapy to treat these blood cancers, enabled via the Cancer Drugs Fund (CDF).

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Casting aside CRISPR scissors and making a point with base editors

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The emergence of novel base editing technologies that do not generate double-strand breaks (DSBs) offer a promising and safer alternative to fine-tune the next generation of immune cell therapies, especially as our need to perform complex multi-gene alterations increases. Another area for potential improvement is the source of immune cells.

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Gilead licenses Jounce immunotherapy for $800m

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Vopratelimab is a monoclonal antibody that binds to and activates the Inducible T Cell CO-Stimulator (ICOS), a protein on the surface of certain T cells that is believed to stimulate an immune response against a patient’s cancer.

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AbbVie, Calico raise their age-related disease alliance funding to $3.5bn

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billion in funding and extended in 2018 with another $1 billion top up – has already resulted in three clinical trial-stage projects for immuno-oncology and neurological diseases, and 20 early-stage programmes. The collaboration with Google sister company Calico – formed in 2014 with $1.5

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Rheumatoid Arthritis

RX Note

Prior to starting DMARD therapy: Screen for hepatitis B, hepatitis C, and latent tuberculosis infections Give all age-/risk-appropriate immunizations before DMARDs or biologics. Management Disease-modifying antirheumatic drugs (DMARDs) are recommended as first-line therapy and should be started early in the diseases course.

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Beyond the pandemic: the potential of mRNA technology

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Further than that, the company has been invested and involved in the area for a few years, after its partnership with BioNTech was agreed back in 2018. Prior to the pandemic, biotech had a market cap of around $6.5bn whereas, at present, it is now valued at approximately $144bn. Biotech leading the charge.

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