pharmaphorum

MARCH 24, 2022

There’s a rich history of finding useful medicines from fungi, from the antibiotic penicillin to immune suppressant cyclosporine and cholesterol drug lovastatin. The examples remain few and far between, however, as in recent decades the pharma industry has turned its attention to synthetic molecules and biologics like antibodies.

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Pharmaceutical Technology

JUNE 12, 2023

CB1 is predominantly found in the central and peripheral nervous system, whereas CB2 is primarily located in immune cells. However, 2017 saw the discontinuation of nabiximols from Phase III development in the US for cancer pain, due to lack of efficacy.

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Immunity Immunization Drug Development 143

LifeProNow

APRIL 11, 2023

Nirsevimabhas been developed to offer newborns and infants direct RSV protection via an antibody to help prevent lower respiratory tract disease (LRTD) caused by RSV.Monoclonal antibodies do not require the activation of the immune system to help offer timely, rapid and direct protection against disease.

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Immunity Immunization 130

STAT

MARCH 6, 2023

“I’m slowly running out of options,” said Young, 62, who in November began   receiving   a five-month series of shots at a clinic near her San Francisco home; the vaccine is designed to teach her immune cells to recognize and combat tumors.

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European Pharmaceutical Review

JANUARY 26, 2023

CAR T-cell therapy engineers a patient’s own immune cells (T-cells) to detect, target and destroy cancer cells. Of those who receive a transplant, about 50 percent will ultimately relapse, stated research from 2017, published in the journal Blood. Could CAR T therapies be manufactured in one day?

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Chemotherapy Immunity Immunization 124

European Pharmaceutical Review

MAY 2, 2024

Sanofi noted that as a long-acting antibody, Beyfortus has been shown to provide rapid protection, helping to prevent lower respiratory tract disease caused by RSV without the immune system needing activation.

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Hospitals Immunity Immunization Vaccines 122

pharmaphorum

DECEMBER 21, 2020

California-based Gilead announced its strong intentions in oncology in 2017 with its $11.9 Sanofi’s acquisition builds on a partnership to develop central nervous system drugs that began in late 2017. billion buy of Kite Pharma and followed that earlier this year by acquiring immuno-oncology firm Forty Seven for $4.9

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Biosimilars Chemotherapy Immunity Immunization 126

European Pharmaceutical Review

JANUARY 26, 2024

highlighted in the paper a key milestone achieved by the vaccine industry in 2017: “the first saponin adjuvant AS01 was approved for use in a human vaccine, the highly effective shingles vaccine Shingrix (produced by GSK).” “Our Martin et al. Our study opens unprecedented opportunities for bioengineering vaccine adjuvants.

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Express Pharma

APRIL 24, 2023

Adults above 50 years of age and those suffering from chronic conditions such as diabetes, heart disease and kidney diseases are at an increased risk of developing shingles because of weakened immunity. Shingrix was approved by the US Food and Drug Administration (FDA) for the prevention of shingles in adults 50 years of age or older in 2017.

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Vaccines Diabetes Immunity Immunization 97

pharmaphorum

FEBRUARY 3, 2021

The emergence of novel base editing technologies that do not generate double-strand breaks (DSBs) offer a promising and safer alternative to fine-tune the next generation of immune cell therapies, especially as our need to perform complex multi-gene alterations increases. Another area for potential improvement is the source of immune cells.

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Immunity Immunization Vaccines 98

Pharmaceutical Technology

DECEMBER 8, 2022

Kite Pharma and Daiichi Sankyo have updated a partnership agreement signed in 2017 for the former’s CAR T-cell therapy, Yescarta (axicabtagene ciloleucel). Directed against a cell membrane protein called CD19, Yescarta uses the immune system of the patient to destroy cancer.

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Communication Immunity Immunization Hospitals 122

The Thyroid Pharmacist

AUGUST 12, 2022

This means that our immune system recognizes the thyroid gland as a foreign invader and begins to attack it, eventually leading to the destruction of our thyroid tissue. Left unbalanced, the immune system may go on to attack different parts of the body, leading to the development of other autoimmune conditions.

Immunity 122

Immunity Immunization Adverse Reactions 122

European Pharmaceutical Review

OCTOBER 21, 2022

A two-dose version of the vaccine was approved by the US Food and Drug Administration (FDA) in 2017. HIV patients have a higher chance of liver-related illnesses and death when additionally infected with HBV, due to lower immune response. The clinical trial is estimated to be completed in March 2023.

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Vaccines Immunity Immunization 96

pharmaphorum

OCTOBER 28, 2021

The two companies have been working together since 2017, with Takeda pledging $100 million to help GammaDelta advance its cell therapy platform as part of a “build-to-buy” arrangement. T cells, a class of lymphocytes that play a role in a host of immune responses and immunopathologies.

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Immunity Immunization 98

European Pharmaceutical Review

MAY 4, 2023

Overall, the mechanisms of action for amivantamab include ligand blocking, receptor degradation, and immune cell-mediated activity. 4 BsMAb amivantamab was designed to enhance adherence of tumour cells to macrophages and natural killer cells, to improve immune-cell mediated killing of cancer cells. 2017; 8(43): 75712–26.

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Immunity Immunization Chemotherapy 98

European Pharmaceutical Review

MAY 23, 2024

Since 2017, six CAR-T cell therapies have been approved by the US Food and Drug Administration (FDA) for the treatment of blood cancers, including lymphomas, some forms of leukaemia, and, most recently, multiple myeloma. CAR T Cells: Engineering Immune Cells to Treat Cancer [Internet]. References National Cancer Institute. Cancer.gov.

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Medical Schools Chemotherapy Immunization Immunity 110

pharmaphorum

APRIL 30, 2021

Janssen entered into a worldwide collaboration and license agreement for cilta-cel with the drug’s originator – China’s Legend Biotech – in December 2017. BMS and bluebird had been hoping for a label allowing third-line use.

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Immunity Immunization Labelling 82

pharmaphorum

JANUARY 19, 2023

Biotech Vaxxas has announced a partnership agreement with the 2017-established Coalition for Epidemic Preparedness Innovations (CEPI), in order to advance the development of Vaxxas’ needle-free vaccine-patch delivery technology with preclinical testing of an mRNA vaccine patch.

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Vaccines Immunity Immunization 105

pharmaphorum

JUNE 7, 2021

Kymriah (tisagenlecleucel) was approved for relapsed/refractory ALL in 2017, but its label covers use in children and young adults aged up to 25, who account for the bulk of cases of the blood cancer. Around a quarter of patients treated with Tecartus had a severe immune reaction, and there were two deaths in the trial.

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Labelling Immunity Immunization 105

Pharmaceutical Technology

AUGUST 1, 2022

AMR occurs when disease-causing bacteria become resistant or immune to the antibiotics used to treat them. A 2017 article in Health Policy estimates that the cost of developing an antibiotic is around $1.5bn, while according to a 2020 article in Nature, the average revenue generated from an antibiotic’s sale is about $46m a year.

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Express Pharma

MARCH 20, 2023

India is preparing to include human papillomavirus (HPV) vaccines as part of the government-driven public immunization program popularly known as the Universal Immunization Program (UIP). The Indian government will float a global tender in April 2023 to procure HPV vaccines.

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Pharmaceutical Technology

NOVEMBER 7, 2022

AstraZeneca Vaccines and Immune Therapies executive vice-president Iskra Reic said: “Beyfortus is the first single-dose preventative option against the respiratory syncytial virus to gain approval in Europe and is also the first and only preventative option approved for a broad infant population. . “The

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Dosage Immunity Immunization Vaccines 64

The Thyroid Pharmacist

OCTOBER 28, 2022

This irritation can interrupt the immune system’s ability to regulate itself, and put the body into a perpetual “attack mode” that is counterproductive to healing. Immune system health and gut health are linked. They can help improve digestion and nutrient extraction from the foods we eat, and can also balance the immune system.

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Health and Personal Care Stores Immunity Immunization Grocery Stores 105

European Pharmaceutical Review

MARCH 11, 2024

For example, broadly neutralising antibodies (bNAbs), capsid inhibitors and maturation inhibitors all might play a role in fighting HIV from the initial binding and fusion of HIV into immune cells, to where it integrates into the cell, out to its assembly and maturation. Internet] 2017. Lancet HIV. 2023;10(5):e295-e307.

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Immunity Immunization Clinical Pharmacology Drug Development 98

European Pharmaceutical Review

AUGUST 1, 2022

The microparticles are made from PLGA using a microfabrication technique they first described in 2017 in the journal Science. This approach could also be used to deliver a range of other therapeutics , including cancer drugs, hormone therapy and biologic drugs, the researchers added.

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Vaccines Immunization Immunity 105

pharmaphorum

FEBRUARY 9, 2021

It interacts with signalling pathways involved in the proliferation of cancer cells and impairs their ability to spread, whilst driving them into programmed cell death (apoptosis) and encouraging a T cell-mediated immune response. Regulus meanwhile remains a microRNA player, but has suffered a number of setbacks.

Immunity 59

Immunity Immunization 59

pharmaphorum

JUNE 8, 2021

If we work closely with government stakeholders and possibly collaborate on developing innovative access schemes for rare diseases, cancers, immune and inflammatory disorders, we can encourage greater participation by established biopharmas and stimulate the growth of entrepreneurial local companies in the region.”. About the author.

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Chemotherapy Pharmaceutical Companies Pharmaceutical Companies Immunization 105

pharmaphorum

JULY 14, 2021

There’s another key difference as well, according to the biotech, which is developing the new shot with big pharma partner Astellas under the terms of an agreement signed in 2017. ASP3772 was also pitted against the combination of Prevnar 13 and Merck’s older polysaccharide-based Pneumovax 23 vaccine.

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Vaccines Immunity Immunization 52

STAT

JULY 24, 2023

percent a year from 2017 to 2019; the yearly increase among women was 2.4 ” The community of microbes that live in the intestines, known as the gut microbiome, is critical to health, and plays a role in digestion and in stimulating the immune system. Wolpin, director of the Gastrointestinal Cancer Center at Dana-Farber.

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Medical Schools Hospitals Chemotherapy Immunization 246

pharmaphorum

OCTOBER 12, 2022

Similar to how we injected mRNA into people to trigger an immune response and train their immune system against COVID-19, genomic medicine repairs cellular or molecular mechanisms that are dysfunctional and cause disease.”. Since 2017, Debiopharm has invested in 14 digital health companies, typically leading the investment rounds.

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Drug Development Immunity Immunization Vaccines 105

European Pharmaceutical Review

AUGUST 22, 2022

based vaccine technology to tackle diseases beyond COVID-19, such as influenza, cancer and AIDS (Acquired Immune Deficiency Syndrome), among others. Moving forward, biopharma companies are exploring the possible extension of the platform?based threatening diseases in the near future. 22(4):040903. WHO Landscape of COVID-19 Vaccine Candidates.

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Vaccines Immunization Immunity 98

Pharmaceutical Technology

AUGUST 12, 2022

Adoptive cell therapy (ACT) is a form of cancer treatment that involves the transfer of immune cells into a patient to help fight the disease, by eliminating cancer cells. They were first licensed for use in 2017 for two forms of blood cancer, acute lymphoblastic leukemia (ALL), and B-cell lymphoma (BCL). billion by the end of 2022.

Immunity 52

Immunity Immunization Chemotherapy Compounding 52

The Thyroid Pharmacist

OCTOBER 14, 2022

It’s also a wonderful tool to boost immunity. (4). I have tested around 300 clients using the GI-MAP test between 2017 and 2019, and 49 percent of people had low secretory IgA.). Essentially, it calms an overactive immune response in the digestive system. Because of the immune and gut-protective benefits of S.

Health and Personal Care Stores 105

Health and Personal Care Stores Immunity Immunization Dosage 105

LifeProNow

APRIL 6, 2023

Imfinzi Imfinzi (durvalumab) is a human monoclonal antibody that binds to the PD-L1 protein and blocks the interaction of PD-L1 with the PD-1 and CD80 proteins, countering the tumour’s immune-evading tactics and releasing the inhibition of immune responses.

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Chemotherapy Immunity Immunization 100

pharmaphorum

DECEMBER 21, 2020

It’s the first major partnership for Janux, which was set up in 2017, and could be the last to be organised by Merck’s R&D head Roger Perlmutter who is retiring from the big pharma company at the end of the year.

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Immunity Immunization 59

RX Note

AUGUST 4, 2023

Alternatively, you may download some of the bookmarked important Malaysia pharmacy reference here.

Hospitals 52

Hospitals Inpatient Community Pharmacies Dosage 52

European Pharmaceutical Review

OCTOBER 19, 2023

Granzyme B is an enzyme released by activated immune cells and using this as a in vivo imaging biomarker has great potential to monitor immune cell activation in a variety of inflammatory diseases, autoimmune diseases, cancer and infections. References Meeting rising demands of a new radiotheranostic era. Internet] Jaafar-Thiel, L.

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