ALiEM - Pharm Pearls

MARCH 29, 2023

2016 Aug; 138(2):e20154381. 2016 Jun 1;170(6):624]. JAMA Pediatr. 2019;173(4):342-351. PMID: 30776077 Gomez B, Mintegi S, Bressan S, et al. Validation of the “Step-by-Step” approach in the management of young febrile infants. The Journal of Pediatrics. PMID: 27382134 Nguyen THP, Young BR, Poggel LE, et al. Hosp Pediatr. JAMA Pediatr.

Hospitals 360

Hospitals Documentation Inpatient Immunity 360

pharmaphorum

JULY 13, 2022

In 2016 it started a $1 billion alliance with AstraZeneca to find drug candidates that could be used to treat respiratory diseases, and extended that in 2018 to include cardiovascular and metabolic disorders. The agreement includes another $12 million to Bicycle, per candidate, if Genentech decides to take a peptide further in development.

Immunity 105

Immunity Immunization Compounding 105

pharmaphorum

JUNE 1, 2021

Patients will also receive a dose of tacrolimus, an immune-suppressing drug, to guard against any immune reaction to the transplanted cells. The hope is that the spheroids will help to replenish damaged cardiomyocytes in the heart, restoring some of its ability to pump blood around the body.

Immunity 138

Immunity Immunization Diabetes 138

pharmaphorum

FEBRUARY 3, 2021

The emergence of novel base editing technologies that do not generate double-strand breaks (DSBs) offer a promising and safer alternative to fine-tune the next generation of immune cell therapies, especially as our need to perform complex multi-gene alterations increases. Another area for potential improvement is the source of immune cells.

Immunity 98

Immunity Immunization Vaccines 98

pharmaphorum

JANUARY 27, 2022

The first patient has been treated with an implantable bioelectronic device developed by Galvani Therapeutics, set up by GlaxoSmithKline and Alphabet’s Verily Life Sciences in 2016. Galvani is using its device to stimulate the splenic nerve, which sends signals to the spleen.

Immunity 110

Immunity Immunization 110

Pharmaceutical Technology

MAY 11, 2023

In 2016, BioNTech and Genentech, a part of Roche signed an agreement to develop personalised mRNA therapies in oncology. The authors of the Nature paper, too, say there is a need for new immunotherapies for patients with non-inflamed tumours that are insensitive to current treatments aimed at immune-inflamed tumours.

Vaccines 138

Vaccines Immunity Immunization 138

European Pharmaceutical Review

AUGUST 9, 2023

While injectable biologic therapies are an effective option for CSU that is uncontrolled by these drugs, less than 20 percent of patients worldwide are treated with them, according to a 2016 British Journal of Dermatology paper and research shared by Novartis. In REMIX-2, the clinical trial enrolled 455 participants with CSU.

Immunity 94

Immunity Immunization Pharmaceutical Companies Pharmaceutical Companies 94

European Pharmaceutical Review

DECEMBER 1, 2022

In order to speed up the regulatory process for advanced medicinal therapy products (ATMPS), the European Union (EU) implemented the priority medicines (PRIME) scheme in 2016. Since the COVID-19 pandemic, there has been a spike in interest in mRNA therapeutics, due to the success of mRNA vaccines treating the virus, observed GlobalData.

Vaccines 98

Vaccines Immunity Immunization 98

Pharmaceutical Technology

OCTOBER 14, 2022

In 2016, the companies entered a strategic partnership to develop novel messenger RNA (mRNA) based PCVs. The mRNA-4157/V940 has been designed to stimulate an immune response by producing T-cell responses depending on the mutational signature of a patient's tumour.

Vaccines 115

Vaccines Research Laboratories Immunity Immunization 115

European Pharmaceutical Review

JANUARY 26, 2023

CAR T-cell therapy engineers a patient’s own immune cells (T-cells) to detect, target and destroy cancer cells. Could CAR T therapies be manufactured in one day?

Chemotherapy 124

Chemotherapy Immunity Immunization 124

European Pharmaceutical Review

SEPTEMBER 22, 2023

The vaccination of patients with AN1792 led to the activation of their immune systems, which started producing endogenous anti-Abeta antibodies. Therefore, active immunotherapy to trigger the immune system to produce sustained levels of endogenous antibodies has now become far more attractive.

Immunity 97

Immunity Immunization Vaccines Communication 97

The Thyroid Pharmacist

JUNE 30, 2023

However, low doses of this medication (hence, low dose naltrexone or LDN), have been found to modulate the immune system and have shown promise in improving cases of autoimmune disease. These include Crohn’s, MS, and Hashimoto’s, as well as other immune system-related conditions such as cancer and HIV/AIDS. Doses of 1.5-4.5

Compounding 98

Compounding Immunity Immunization Compounding Pharmacies 98

pharmaphorum

SEPTEMBER 22, 2021

Texas-based Abexxa has been on the Boehringer’s radar since it was set up, as it provided seed funding for the preclinical-stage company in 2016, buying into its approach of developing antibodies against targets inside cancer cells, rather than on the cell membrane.

Vaccines 92

Vaccines Immunity Immunization 92

pharmaphorum

JANUARY 7, 2022

Sanofi and Exscientia first started working together in 2016, initially on a fairly small-scale programme focused on bispecific small-molecule drugs for metabolic diseases, with a total value of around $275 million. The French drugmaker is paying $100 million upfront in the deal, but the total value could swell to a massive $5.2

Immunity 110

Immunity Immunization 110

Pharmaceutical Technology

FEBRUARY 3, 2023

Starting in 2016, the South African Uhambo HVTN 702 study, studied the ALVAC vaccine followed by a different booster , but the trial was unsuccessful. We believe we’re going to need multiple different vaccines that will gently coax the immune system to make these bNAbs,” he says.

Vaccines 117

Vaccines Immunity Immunization 117

pharmaphorum

DECEMBER 14, 2022

The vaccine primes the immune system to attack the tumour cells, while Keytruda blocks an immunological ‘brake’ that protects the cancer. In October, Merck took up an option on the personalised RNA-based cancer vaccine with an upfront payment of $250 million as part of a collaboration first agreed in 2016 and expanded in 2018.

Vaccines 98

Vaccines Immunity Immunization 98

pharmaphorum

JUNE 17, 2021

Last September, Roche/Genentech and AC Immune reported a comprehensive failure for their anti-tau antibody semorinemab at the interim stage of the phase 2 TAURIEL trial in patients with early-stage Alzheimer’s.

Immunity 98

Immunity Immunization 98

pharmaphorum

SEPTEMBER 13, 2022

Crucially, he observed a connection between certain tumours and inflammation, noting that neoplastic tissues were often covered with leukocytes of the immune system. Building on the success of cytokine-based immunotherapies, scientists continued to seek other areas where the immune system could be leveraged against tumours.

Chemotherapy 98

Chemotherapy Immunity Immunization Documentation 98

European Pharmaceutical Review

SEPTEMBER 5, 2024

2 These are cells commonly found in the stroma of the tumour, which play an important role in inhibiting the body’s own immune response to the tumour, mediated through CD8+ T-cells (tumour-infiltrating lymphocytes). Research in the last few years has shown NOX4 in tumour cells is linked to the growth of cancer-associated fibroblasts (CAFs).

Immunity 59

Immunity Immunization Diabetes 59

European Pharmaceutical Review

DECEMBER 20, 2022

This technology is creating an entirely new class of molecules to induce synthetic immunity against cancer by harnessing NK cell effector functions against cancer cells and also providing proliferation and activation signals targeted to NK cells. Building on Sanofi’s and Innate Pharma’s original license agreement.

Immunity 98

Immunity Immunization 98

pharmaphorum

JANUARY 8, 2021

This highlights a potential early window for treatment where the sickest patients may gain the most benefit from immune modulation treatment,” he added. “A crucial difference may be that in our study, critically ill patients were enrolled within 24 hours of starting organ support.

Hospitals 105

Hospitals Immunity Immunization 105

European Pharmaceutical Review

AUGUST 26, 2022

Moderna has filed patent infringement lawsuits alleging that Pfizer and BioNTech’s COVID-19 vaccine Comirnaty ® infringes patents Moderna filed between 2010 and 2016 covering its foundational messenger RNA (mRNA) technology. ” But why sue now?

Vaccines 98

Vaccines Immunity Immunization 98

European Pharmaceutical Review

JUNE 13, 2023

In IgAN, autoimmune reaction to an abnormal form of IgA results in formation of immune complexes that deposit in the kidney. These immune complexes trigger inflammation and kidney damage. This then leads to progressive loss of renal function, according to a 2016 paper published in Nature Reviews Disease Primers. The post £2.5b

Immunity 52

Immunity Immunization 52

pharmaphorum

SEPTEMBER 2, 2020

Vopratelimab is a monoclonal antibody that binds to and activates the Inducible T Cell CO-Stimulator (ICOS), a protein on the surface of certain T cells that is believed to stimulate an immune response against a patient’s cancer. In 2016 Celgene signed a $2.6

Immunity 71

Immunity Immunization 71

The Thyroid Pharmacist

OCTOBER 14, 2022

It’s also a wonderful tool to boost immunity. (4). boulardii has been shown to help raise secretory IgA, an immunoglobulin (antibody) that plays a critical role in the immune function of the mucosal linings of the body, and helps to provide a protective barrier (SIgA is the first line of defense for the respiratory and GI tract). (4)

Health and Personal Care Stores 105

Health and Personal Care Stores Immunity Immunization Dosage 105

The Thyroid Pharmacist

DECEMBER 28, 2022

Vitamin D supports the immune system by enhancing the pathogen-fighting effects of white blood cells, which are important parts of immune defense. Supplementing with vitamin D can especially help to improve mood and cognitive function during the winter months, as well as improve immune function. I recommend doses of 1.5

Immunity 111

Immunity Immunization Clinical Pharmacology Doctor of Pharmacy 111

pharmaphorum

NOVEMBER 4, 2020

A PD-L1 class checkpoint inhibitor, Tecentriq works by calling in an attack from the patient’s immune system and since hitting the market in 2016 has already picked up US approvals in a range of oncology indications including lung and bladder cancer.

Adverse Reactions 64

Adverse Reactions Biosimilars Immunity Immunization 64

pharmaphorum

JUNE 9, 2021

After transplant, the 10 subjects in the study will take immunosuppressant drugs to prevent their immune system from rejecting the transplant. They will be followed up for two years, looking at safety, tolerability, the survival of the cells and the impact on Parkinson’s symptoms, with final results due in November 2023.

Immunity 91

Immunity Immunization 91

Pharmaceutical Technology

FEBRUARY 8, 2023

Since 2016, the facility has been manufacturing lentiviral vectors (LVV) and drug product for the ongoing programmes of Genenta. Under the deal, AGC Biologics will be responsible for manufacturing the cell therapy lentivirus-based product for the ongoing clinical programmes of Genenta Science.

Immunity 52

Immunity Immunization 52

pharmaphorum

JANUARY 6, 2023

While cTTP represents a tiny patient population for TAK-755, Takeda is also running trials of the drug in other indications, including a phase 2 study in acquired or immune-mediated TTP (iTTP) and phase 1 in sickle cell disease (SCD), which if positive could expand the number of patients eligible for treatment.

Immunity 59

Immunity Immunization 59

pharmaphorum

OCTOBER 7, 2022

TauRx was an early proponent of the notion that tau protein could be a legitimate drug target in Alzheimer’s, since it was taken up by a lot of larger companies, including Roche/UCB , Johnson & Johnson/AC Immune , and Eisai , amongst others.

Immunity 85

Immunity Immunization 85

The Thyroid Pharmacist

JUNE 16, 2023

6] It is also antimicrobial, antifungal and anti-inflammatory, and can modulate the immune system. Thyroid Function Although there is a lot of data on black seed oil, there had been little study in the Hashimoto’s population, until a 2016 Iranian study looked at the therapeutic use of black seed oil in people with Hashimoto’s thyroiditis. [7]

Diabetes 116

Diabetes Dosage Compounding Immunity 116

pharmaphorum

MARCH 11, 2022

For now, people in England without COVID symptoms can order one pack of seven LFTs every three days – previously it was one per day – until free access ends at the end of the month for anyone aged under 75 or with weakened immune systems. The situation isn’t clear in other areas of the UK.

Immunity 59

Immunity Immunization 59

European Pharmaceutical Review

FEBRUARY 22, 2023

Of the 175 new drugs approved by the US Food and Drug Administration (FDA) between 2016 and 2019, most were biologics. Biologics represent an increasingly large part of the pharmaceutical industry. 2 Most biotherapeutics are delivered parenterally, with some exceptions being ocular or inhaled formulations.

Biosimilars 105

Biosimilars Diabetes Immunity Immunization 105

pharmaphorum

MARCH 29, 2021

We are even at a point where some cancer medicines are created for each individual patient using their own immune system. “We have gone from making drugs for breast cancer to making drugs that are targeted to just specific types of breast cancer that express certain genetic markers.

Drug Development 93

Drug Development Immunity Immunization 93

pharmaphorum

SEPTEMBER 22, 2020

The biotech’s R&D focus has been on inflammasomes – intracellular groups of proteins that act as part of the innate immune system to respond to pathogens but can also run amok and cause inflammatory diseases.

Immunity 59

Immunity Immunization 59

The Thyroid Pharmacist

AUGUST 19, 2022

8) In very simple terms, this theory hypothesizes that our immune system begins to attack our own thyroid gland because we are infected with a pathogenic organism (like a bacterium, parasite , or virus ), that looks similar to components of the thyroid gland. Molecular mimicry is one of the leading theories of autoimmune disease. (8)

Health and Personal Care Stores 98

Health and Personal Care Stores Immunity Immunization Dosage 98