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JAMA 2016; 316(20): 2115-25.) Risks of Polypharmacy Polypharmacy is associated with several categories of adverse effects, each with significant implications for patient health, safety and total cost of care. JAMA 2016; 316(20): 2115-25. Shehab et al. This dependency can affect their self-esteem and quality of life. Hilmer, S.
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