World Pharma News

FEBRUARY 25, 2025

Vaccines to treat cancers have been around since 2010, the first being approved for prostate cancer, and another in 2015 for melanoma. One hurdle is the difficulty in finding antigens in tumors that look foreign enough to trigger an immune response.

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Vaccines Immunity Immunization 50

LifeProNow

MARCH 24, 2023

Since launching the first biosimilar in the US in 2015, Sandoz has proven biosimilars create early and expanded patient access to life-altering medicines while increasing healthcare savings and creating competition that fuels innovation and development of new and enhanced treatments in areas of unmet need.

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Biosimilars Immunity Immunization 130

pharmaphorum

NOVEMBER 17, 2020

Lead Pharma has signed a potential 260 million euro ($308 million) deal with Roche to develop small molecule drugs for immune diseases. The company has been working with Sanofi since 2015 on a small molecule targeting ROR gamma, a regulator of T-helper 17 immune cells. Roche last year signed a $792.5 The US biotech got $42.5

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Immunity Immunization Biosimilars 72

pharmaphorum

MARCH 24, 2022

There’s a rich history of finding useful medicines from fungi, from the antibiotic penicillin to immune suppressant cyclosporine and cholesterol drug lovastatin. The examples remain few and far between, however, as in recent decades the pharma industry has turned its attention to synthetic molecules and biologics like antibodies.

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Compounding Immunity Immunization Drug Development 105

Pharmaceutical Business Review

NOVEMBER 24, 2023

A therapy platform developed by T3 Pharma using engineered Yersinia enterocolitica bacteria, delivers immune-modulating proteins to cancer cells and tumour micro-environments, sparing healthy tissues. T3 Pharma was founded in 2015 as a spin-off from the Biozentrum of the University of Basel.

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Immunity Immunization 59

STAT

JULY 24, 2023

Breast cancer has also shown an  accelerating increase  among women under 50, rising only slightly from 2000 to 2015 but increasing by 2 percent a year from 2015 to 2019. The rise is seen “in both men and women and in all races and ethnicities and around the world,” said Ng, of Dana-Farber.

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Medical Schools Hospitals Chemotherapy Immunity 246

European Pharmaceutical Review

APRIL 10, 2024

While this approach has shown to be safe and efficient in Clostridium difficile, the variability between donors may lead to random outcomes and responses in patients for immune-mediated diseases. Notably, from one donor to another, significant variations exist.

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Immunity Immunization Chemotherapy Diabetes 95

pharmaphorum

JANUARY 26, 2023

More specifically, CAR-T cell therapy engineers a patient’s own immune cells (T-cells) to detect, target, and destroy cancer cells. CAR-T cell therapy is an individualised treatment for patients, currently licensed for people living with some types of blood cancer.

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Chemotherapy Immunity Immunization Hospitals 96

European Pharmaceutical Review

AUGUST 26, 2022

According to Moderna, the chemical modification avoids provoking an undesirable immune response when mRNA is introduced into the body and has been worked on by scientist at the company since 2010 and first validated by Moderna in human trials in 2015. ” But why sue now?

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Vaccines Immunization Immunity 98

The Thyroid Pharmacist

JUNE 30, 2023

In 2015, I conducted a survey of over 2000 readers with Hashimoto’s , asking for the most helpful interventions in their health journeys. However, low doses of this medication (hence, low dose naltrexone or LDN), have been found to modulate the immune system and have shown promise in improving cases of autoimmune disease. Doses of 1.5-4.5

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Compounding Immunity Immunization Compounding Pharmacies 98

European Pharmaceutical Review

MARCH 11, 2024

In fact, a study published in 2023 in The Lancet HIV revealed that women and men with HIV at age 40 had an average of 39 and 37 years of life left, respectively – only a few years less than that of the general population – if they started antiretroviral therapy (ART) after 2015. World Health Organization. The Global Health Observatory.

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Immunity Immunization Clinical Pharmacology Drug Development 98

pharmaphorum

SEPTEMBER 13, 2022

Crucially, he observed a connection between certain tumours and inflammation, noting that neoplastic tissues were often covered with leukocytes of the immune system. Building on the success of cytokine-based immunotherapies, scientists continued to seek other areas where the immune system could be leveraged against tumours.

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Chemotherapy Immunity Immunization Documentation 98

European Pharmaceutical Review

SEPTEMBER 5, 2024

2 These are cells commonly found in the stroma of the tumour, which play an important role in inhibiting the body’s own immune response to the tumour, mediated through CD8+ T-cells (tumour-infiltrating lymphocytes). 2015; 23(5):358–74. Phase II data in squamous cell carcinoma of the head and neck (SCCHN) was announced in May this year.

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Immunity Immunization Diabetes 59

The Thyroid Pharmacist

DECEMBER 28, 2022

Then in 2015, I realized that we, the thyroid community, have the power to conduct our own research! In this article (which was originally published in 2015), we’ll dive into the results of the survey and discuss some important considerations for those with Hashimoto’s, including: How stress contributes to Hashimoto’s.

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Immunity Immunization Clinical Pharmacology Doctor of Pharmacy 111

The Thyroid Pharmacist

OCTOBER 28, 2022

This irritation can interrupt the immune system’s ability to regulate itself, and put the body into a perpetual “attack mode” that is counterproductive to healing. Immune system health and gut health are linked. They can help improve digestion and nutrient extraction from the foods we eat, and can also balance the immune system.

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Health and Personal Care Stores Immunity Immunization Grocery Stores 105

The Thyroid Pharmacist

DECEMBER 15, 2023

2] Food sensitivities – Proteins that are not properly broken down, are more likely to induce an antigenic response from our immune system, leading to food sensitivities (especially to gluten and dairy ). [3] Infect Immun. Food allergy: immune mechanisms, diagnosis and immunotherapy. World Journal of Gastroenterology.

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Immunity Immunization Dosage 98

pharmaphorum

NOVEMBER 2, 2021

The more targeted, bispecific functionality of bsAbs broadens the reach of antibody-mediated therapies against both solid and haematological cancers, creating novel approaches that can induce a tumour-specific immune response, target immune checkpoints, or improve payload delivery to tumour cells (Fig. Targeted delivery of payloads.

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Immunity Immunization 52

Safe Biologics

NOVEMBER 12, 2023

The product is an interleukin-6 (IL-6) receptor antagonist that targets specific inflammatory proteins to suppress the immune system. This is the first biosimilar approved to treat systemic juvenile idiopathic arthritis, and the 43rd biosimilar approved by the FDA since 2015. It is administered via intravenous infusion.

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Biosimilars Drug Pricing Packaging Labelling 130

pharmaphorum

FEBRUARY 9, 2021

The Series B funding has come more than five years after InteRNA’s first-round, which raised just over $10 million in 2015, and nine months after the biotech was cleared to start trials of INT-1B3 in the Netherlands and Belgium. Dutch biotech InteRNA Technologies has raised €18.5

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Immunity Immunization 59

pharmaphorum

SEPTEMBER 22, 2020

The biotech’s R&D focus has been on inflammasomes – intracellular groups of proteins that act as part of the innate immune system to respond to pathogens but can also run amok and cause inflammatory diseases.

Immunity 59

Immunity Immunization 59

pharmaphorum

DECEMBER 6, 2022

The debit facility is being provided by Summit’s co-chief executives Bob Duggan and Maky Zanganeh, both veterans of Pharmacyclics who pocketed rich rewards when the company was sold to AbbVie for $21 billion in 2015.

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Chemotherapy Immunity Immunization 52

The Thyroid Pharmacist

NOVEMBER 17, 2022

Her body was making numerous inflammatory immune complexes to EVERY protein she was eating! She also began using systemic enzymes (enzymes that are taken away from food and break down inflammatory immune complexes), and started noticing that her eyes and face were less swollen — within a few weeks.

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Health and Personal Care Stores Immunity Immunization Compounding 98

Pharmaceutical Technology

AUGUST 26, 2022

A 2015 study showed that both routes of administration (ROA) produce similar immune responses but that intradermal ROA produced more swelling at the injection site.) The EUA also allows subcutaneous administration to individuals under 18 years old who are at high risk of monkeypox.

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Vaccines Immunity Immunization 52

pharmaphorum

JANUARY 10, 2022

In theory at least, that should make them easier to administer and less likely to stimulate an immune reaction in the recipient, overcoming two challenges with gene-editing therapies. .” The California biotech has been attracting attention from other pharma groups because the enzymes used in its CRISPR platform – Cas14 and Cas?

Immunity 52

Immunity Immunization 52

pharmaphorum

AUGUST 28, 2020

Cassiopea is also developing clascoterone as a topical solution for hair loss in men and women, which could also be a big market opportunity if planned phase 3 studies are successful, and has an immune modulator drug for genital warts in mid-stage testing. Cassiopea spun out of Ireland-domiciled Cosmo Pharma in 2015.

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Immunity Immunization 52

The Thyroid Pharmacist

DECEMBER 6, 2023

Limiting the Intake of Fish High in Mercury Levels Seafood is rich in omega-3 fatty acids, which can help restore immune balance and reduce inflammation. 9] Seventy percent of readers in my 2015 survey found that bone broth helped them feel better. You will be able to improve your tolerance to carbohydrates as you heal.

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Immunization Immunity Adverse Reactions Packaging 98

pharmaphorum

JANUARY 17, 2022

In 2015, Martin Shkreli, former chief executive of Turing Pharmaceuticals, which is now known as Vyera, obtained the exclusive rights to Daraprim , which is used to treat toxoplasmosis, a parasitic disease that most commonly affects pregnant women and people with Aids, malaria and cancer.

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Immunity Immunization Drug Pricing 45

pharmaphorum

OCTOBER 30, 2022

The two groups were also separated by a sizeable time difference, with data from the control group ranging between 1990 and 2015, while Study 03-133 started enrolling patients in 2004. Changes in standard and supportive care over the time period could also have skewed the results, said the FDA reviewer. .

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Documentation Labelling Immunity Immunization 52

pharmaphorum

JUNE 8, 2021

If we work closely with government stakeholders and possibly collaborate on developing innovative access schemes for rare diseases, cancers, immune and inflammatory disorders, we can encourage greater participation by established biopharmas and stimulate the growth of entrepreneurial local companies in the region.”. million in 2030.

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Chemotherapy Pharmaceutical Companies Pharmaceutical Companies Immunity 105

Pharmacy Friday Pearls

MARCH 9, 2022

Crotalidae Polyvalent Immune FAB (Ovine). Crotalidae Immune F(ab’)2 (Equine). Patients can develop delayed or recurrent hematologic symptoms up to a week after treatment cessation, especially following a severe envenomation. Pharmacology. in the treatment group vs 7.4 in the control group (95% CI 0.1 – 2.3; 2020;77(3):175-187.

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Immunity Immunization Packaging Labelling 40

pharmaphorum

JULY 9, 2021

Ampersand Health has been working in the space since 2015 and has seen it evolve from a niche approach with limited acceptance to widespread acceptance and deployment across disease areas in a matter of years. Dr Bu Hayee is a consultant gastroenterologist at King’s College Hospital and has been chief of service since 2015.

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Hospitals Communication Immunity Immunization 69

RX Note

AUGUST 4, 2023

Apart from Malaysian Clinical Practice Guidelines , other recommended local references include: ADR Reporters Guide Ampang Protocol, 2012 Anticoagulation MTAC Protocol, 2020 Antidote Quick Guide, 2022 Cancer Drug Counselling A Guide for Pharmacist, 2017 Clinical Pharmacokinetics Pharmacy Handbook, 2019 Code of Ethics for Pharmacists, 2018 Critical (..)

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Hospitals Inpatient Community Pharmacies Dosage 52

RX Note

MARCH 28, 2023

Each episode of infection induces a life-long protective immunity to the homologous serotype but confers only partial and transient protection against other serotypes. External Links CDC - Dengue Dengue and Severe Dengue WHO Handbook for Clinical Management of Dengue CPG Management of Dengue Infection in Adults, 2015

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Vaccines Clinic Management Diabetes Immunity 52

pharmaphorum

MARCH 21, 2022

Like PD-1, LAG-3 is a negative regulator of T cells, suppressing their activity against cancer cells, so when that brake is released the immune system can attack and kill tumours. months, versus 4.6 months for Opdivo alone.

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Biosimilars Immunity Immunization 52

The Thyroid Pharmacist

AUGUST 19, 2022

8) In very simple terms, this theory hypothesizes that our immune system begins to attack our own thyroid gland because we are infected with a pathogenic organism (like a bacterium, parasite , or virus ), that looks similar to components of the thyroid gland. Molecular mimicry is one of the leading theories of autoimmune disease. (8)

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Health and Personal Care Stores Immunization Immunity Dosage 98

The Thyroid Pharmacist

NOVEMBER 10, 2023

Food sensitivities differ from allergies in that they activate separate branches of the immune system. While food allergies are generated by the IgE branch of the immune system, food sensitivities are generated by the IgG, IgA, and IgM branches, and reactions do not appear immediately. Published 2015 Feb 27. 2015;7(3):1565-1576.

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Immunity Immunization Labelling 105

FDA Law Blog: Biosimilars

NOVEMBER 1, 2023

Counterarguments abound, many of which were detailed in 2015 in a publication by counsel for the American Clinical Laboratory Association ( here ). Even so, the entry of a stay pending final judgment may not be sufficient to immunize parties who rely on LDTs from the PR’s consequences.

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Hospitals Immunity Immunization 81