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Sosei Heptares’ longstanding alliance with Pfizer has advanced a first candidate into phase 2 testing: an oral GLP-1 agonist for diabetes and obesity that will try to take on established rivals from Novo Nordisk and Eli Lilly. The post Sosei nets $10m Pfizer milestone as diabetes/obesity drug starts phase 2 appeared first on.
A review paper published in 2010 that discussed the relationship between thyroid dysfunction and metabolic disorders, highlighted the fact that patients with diabetes were up to three times more likely to develop a thyroid disorder. (7). Hypoglycemia is an early risk factor for developing diabetes. Type 2 Diabetes.
Introduction I still remember, during university years, there is a long list of recommended reading for each subject, which we might or might not give it a read. Regardless, this post is solely created as a collection of recommended reference.
I knew he was right — sugar can contribute to a yeast overgrowth, lowered immunity, blood sugar issues, weight gain, diabetes, and a whole host of health problems (1-3) — but I was a sugar addict, and it was devastating to think that I would have to let go of this old friend and not have any sweetness in my life. What is Stevia?
However, aging also brings about physiological and pathological changes that increase the risk of developing multiple chronic diseases, such as cardiovascular disease, stroke, and diabetes. This demographic shift is likely to increase the prevalence of chronic diseases, further boosting polypharmacy rates.
Pycnogenol ® is much more than just an ingredient First and foremost, Pycnogenol ® stands apart from single compounds. Pycnogenol ® French maritime pine bark extract’s unique blend of active compounds cannot be found in any other plant extract. Each of its compounds provides a different way of acting in the body.
The drugs available at Malaysia is not available at US drug market and hence would not be covered in this book, such as benserazide/ levodopa combination (Madopar) in Parkinson disease and gliclazide in diabetes management. Compounding and dispensing competencies. The books are arranged in alphabetical order.
Introduction In parallel with industrialization, the focus of pharmacists' practice has evolved from compounding and dispensing medications to the provision of professional services for patients. 2015) showed that NHS costs were significantly lower when patients were treated for minor ailments through community pharmacies.
Uses and Benefits of Black Seed Oil Many of the medicinal properties of black seed oil are attributed to the compounds it contains, including thymoquinone (TQ), thymohydroquinone (THQ) and dihydrothymoquinone (DHTQ). Black seed oil also contains the antifungal compounds thymol and THQ. 2015; 95-96: 138-58. doi: 10.1016/j.phrs.2015.03.011
It was at this time they set their site at Sandwich in the UK, initially just to finish processing compounds imported from America, but due to tariffs on imported products the company rapidly expanded the plant to accommodate producing medicines from scratch. The 1990s and 2000s would soon take this blockbuster-based success to new levels.
Apart from Malaysian Clinical Practice Guidelines , other recommended local references include: ADR Reporters Guide Ampang Protocol, 2012 Anticoagulation MTAC Protocol, 2020 Antidote Quick Guide, 2022 Cancer Drug Counselling A Guide for Pharmacist, 2017 Clinical Pharmacokinetics Pharmacy Handbook, 2019 Code of Ethics for Pharmacists, 2018 Critical (..)
Myo-inositol has been found to provide many valuable health effects, including anti-inflammatory, anti-oxidant, anti-diabetic, and anticancer effects. (7). The authors of this study also pointed out that these two compounds were safe, with no side effects seen as part of their data collection. Recommended Dosage and Precautions.
Recommendations for Those on T4/T3 Combination Medications If you’re taking a combination medication that contains both T4 and T3 (such as Armour, Nature-Throid, WP Thyroid, or compounded T4/T3), the timing of your tests does matter and may make a huge difference in getting you on an appropriate medication dose. 2007;115(04):261-267.
Studies connect chronic inflammation with many modern human diseases, including cardiovascular disease, type 2 diabetes , and cancer. 24] Type 2 Diabetes Inflammation (along with oxidative stress) plays a crucial role in the development of insulin resistance and type 2 diabetes. 2015 Jan 1;20:872-91; Yi D, Hou Y, Xiao H, et al.
Benefits and Uses of Curcumin Turmeric’s medicinal benefits can mostly be attributed to compounds called curcuminoids. Combining curcumin with piperine, an alkaloid found in black pepper, extends the life of curcumin in the body, making its compounds more therapeutically effective. Curcumin is the active component in turmeric.
Herbal Bitters includes: Ginger : The spicy warmth of ginger comes from gingerol and shogaol, compounds called gingeroids. These compounds are responsible for most of ginger’s beneficial effects on digestion, such as ameliorating occasional indigestion, bloating, belching, and discomfort after meals. Diabetic nephropathy.
In my 2015 survey, 81 percent of my readers with Hashimoto’s said they felt better on this diet!) Research has shown glutamine to be effective in restoring insulin response in diabetics. [23] Myo-inositol for insulin resistance, metabolic syndrome, polycystic ovary syndrome and gestational diabetes. Nutr Metab (Lond).
Diabetic Neuropathy Diabetic neuropathy, a common complication of long-term high blood sugar and insulin resistance, can cause constipation. 40] Additionally, some diabetes medications can contribute to this issue. According to a 2015 research review, 100 milligrams of ginger extract may increase bowel movements. [63]
I’ve seen a number of airborne toxins showing up as frequent triggers/exacerbating factors for my clients’ autoimmune conditions — mold, volatile organic compounds (VOCs), and artificial/synthetic fragrances, in particular. For cleaning products, only compounds need to be identified. Volatile Organic Compounds (VOCs) .
In 2015, 80 percent of my clients who hit a plateau with nutrition and took the gut tests I recommended, tested positive for at least one gut infection. Thymoquinone (TQ), one of the active compounds found in black seed oil, acts as a biofilm disruptor, meaning that it can break free from the protective coating that H. J Diabetes Res.
Selenium intake may also cause side effects in those with diabetes. One study found that people who took 200 micrograms a day of selenium, were 50 percent more likely to develop type 2 diabetes. (64) Exp Clin Endocrinol Diabetes. Exp Clin Endocrinol Diabetes. Krysiak R, Szkróbka W, Okopie?. 2018 Jul 30. 2018 Jul 30.
Other plants also contain this organic compound, but aloe vera contains an especially large amount, with over 12 different anthraquinones. Not only did fasting blood sugar levels drop, but triglyceride levels (levels of fat in the blood, which are associated with type 2 diabetes ) did as well. (8). Infections. Immune Health.
Chemically, protein is composed of amino acids , which are organic compounds made of carbon, hydrogen, nitrogen, oxygen, or sulfur. Effects of glutamine on glycemic control during and after exercise in adolescents with type 1 diabetes: a pilot study. Diabetes Care. 2015 Mar 24;7(4):2101-8. Published 2015 Jan 21.
Abnormal levels of thyroid hormone are associated with blood sugar abnormalities (and poor insulin control), and abnormal levels of pancreatic hormones have been linked to metabolic disorders, as well as diabetes. [2] Again, having low stomach acid further compounds this by providing an environment that is not well defended against bacteria.
A 2015 study in Sicily found that people living closer to a petrochemical complex, and thus are subject to its pollution, were more likely to have a greater frequency of thyroid nodules as well as Hashimoto’s. [15] Thyroid dysfunction in patients with diabetes: clinical implications and screening strategies. Endokrynol Pol.
One study found increased obsessive-compulsive symptoms in men with type 1 diabetes. Another found that OCD patients had a higher risk of developing type 2 diabetes. Obsessive-compulsive symptoms were also found to be positively correlated with blood levels of HbA1c, a commonly used diagnostic measure of type 2 diabetes.
I’ve seen people gain hundreds of pounds in the course of a year, become diabetic, lethargic, and withdrawn, and develop irreversible, involuntary movements and painful muscle contractions, from using antipsychotic medications. Published 2015 Jul 23. 2015;7(8):6055-6072. doi:10.3390/nu7085270. Wani AL, Bhat SA, Ara A. Integr Med Res.
In 2015, I did a survey of my readers consisting of 2232 people having Hashimoto’s. In my 2015 survey, 60 percent of respondents felt better when they removed soy from their diet, and there was a 34 percent reduction in antibodies. You can read more about removing dairy here. That ended up being gut infections!
A 2015 case report documented the thyroid labs of a man who had recurrent hyperthyroid episodes after three of his wife’s pregnancies! In fact, in 2006, the Centers for Disease Control reported that the average American has 116 out of the 148 commonly tested synthetic compounds in their body. January 8, 2015. Updated 2021.
Many facts that you are going to read below, are based on the insights shared by over 2000 of my clients and readers, whom I surveyed back in 2015. A 2015 study out of England reported that people in an area with fluoridated drinking water were twice as likely as those in a non-fluoridated area to report hypothyroidism. [16]
Not only did my compounding pharmacist assure me that adrenal dysfunction was real, but also helped me realize that I had it. Please note that electrolyte imbalances may be compounded by intense exercise, living in a hot or dry climate, and drinking caffeine or alcohol. I’ll discuss ways to increase your levels below!)
11] In fact, the 2015–2020 Dietary Guidelines for Americans removed the recommendations to restrict dietary cholesterol to 300 mg/day. Sulfur: In the case of relative estrogen dominance, cruciferous vegetables, which contain glucosinolates (sulfur-rich compounds), are a great way to reduce estrogen levels in the body. J Chem Neuroanat.
Scientists in Bosnia first published this connection in 2015, though I’ve seen it clinically since 2013. (1). In 2015, 35 percent of my clients reported testing positive for Blasto. Berberine contains compounds called alkaloids that have broad-spectrum antimicrobial and antiparasitic properties. (33). Published 2015 Jul 30.
In 2015, some 80 percent of my clients who took the gut tests that I recommended, tested positive for at least one gut infection!) In fact, a 2015 Polish study found the Epstein-Barr virus in the thyroid cells of 80 percent of people with Hashimoto’s, while controls did not have EBV present in their thyroid gland. [46] In: StatPearls.
I subsequently learned that the risk of having carpal tunnel increases during pregnancy as well as in people with hypothyroidism, rheumatoid arthritis, diabetes, obesity, and other inflammatory and metabolic health conditions. I know so many people who have had surgery for carpal tunnel syndrome, but I was hoping to avoid surgery if I could.
A 2015 study published in Endokrynologia Polska found the Epstein-Barr virus in the thyroid cells of 80 percent of people with Hashimoto’s and 62.5 Some individuals may be sensitive to anthraquinone compounds, which are present in aloe latex (taken from the outer skin of the plant) and aloe whole leaf extracts.
In my survey of over 2,000 readers, 76 percent reported improved energy while taking compounded T3/T4, 74 percent while taking Armour Thyroid*, 74 percent with Cytomel, and 72 percent with Nature-Throid. The diet can lower your risk of developing diabetes, heart disease, and some cancers as well. (34-37). Diabetes Metab Res Rev.
7] (This is also linked to the type 2 diabetes epidemic.). I started talking to Carter Black, RPh, my compounding pharmacist, about the symptoms I was experiencing, and he suggested that I have my adrenals tested. Published 2015 Nov 1. National Institute of Diabetes and Digestive and Kidney Diseases. Inflammation.
Some report more weight loss with T4/T3 combinations (Armour*, Nature-Throid, compounded medications) versus T4 medications (Synthroid, Levoxyl, Tirosint) alone. Sixty-three percent of 2332 readers that I surveyed in 2015 reported positive weight changes when they tried the AIP diet! Price diet, or the Mediterranean diet. 2007-2404. [3]
In 2015, my team and I analyzed the data from 298 clients and participants enrolled in our Hashimotos Self-Management Program (HSMP) who took the GI-MAP. Low levels of this beneficial bacteria are associated with metabolic dysfunction, inflammation, type 2 diabetes, and obesity. [8] Published 2015 Apr 2. Published 2015 Apr 2.
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