pharmaphorum

NOVEMBER 29, 2022

By enabling strong CD8 T-cell infiltration in cold tumor tissues, NT-I7, a compound developed by NeoImmuneTech, is capable of promoting a microenvironment that contributes to clinical efficacy, when combined with a CPI. Dr Se Hwan Yang, PhD, President and Chief Executive Officer, founded NeoImmuneTech in January 2014. Creation: Jan.

Immunization 105

Immunization Immunity Chemotherapy Compounding 105

Express Pharma

JUNE 28, 2024

In 2014, the market size for Ayurveda products was around $3 billion. He shared that this growth is underpinned by robust regulatory frameworks, often mirroring US standards and a holistic approach to isolating compounds in traditional medicines. By 2021, a survey revealed the market size had surged to $18.2

Hospitals 73

Hospitals Compounding 73

PharmaShots

FEBRUARY 22, 2023

In the US, Trulicity is protected by a compound patent (2027) and by biologics data protection (2026). million patients’ journeys with type 2 diabetes since 2014. Active Ingredient: dulaglutide Dosage Forms & Strengths: Injection: 0.75 mL, 3 mg/0.5 Trulicity has been a part of over 2.8

Diabetes 64

Diabetes Compounding Dosage Communication 64

PharmD Live

MAY 30, 2024

The side effects can compound, resulting in a greater negative impact on a patient’s health than the individual effects of one medication alone. US Emergency Department Visits for Outpatient Adverse Drug Events, 2013-2014. Adverse Drug Reactions (ADRs) Adverse drug reactions are a major concern in polypharmacy. Campbell, N.

Clinical Pharmacology 119

Clinical Pharmacology Hospitals Long-Term Care Facilities Dosage 119

Pharmacy Joe

OCTOBER 25, 2023

The removal appears to be in response to the publication of a 2021 article in the International Journal of Pharmaceutical Compounding. The list was originally compiled and updated by John Mitchell, PharmD, who passed away on June 10, 2014.

Dosage 111

Dosage Inpatient Packaging Documentation 111

The Happy PharmD

OCTOBER 28, 2024

billion in revenue by 2014, it paled in comparison to the colossal figures of CVS and Walgreens, which raked in $139 billion and $76 billion, respectively. Target’s overall profit margins were low, compounded by costly operational issues and the aftermath of shutting down its Canadian operations, which resulted in a $2.5

Compounding 52

Compounding Communication 52

pharmaphorum

JANUARY 9, 2023

It also has potential in NDD, although it was discontinued as a treatment of fragile X syndrome in 2014 after disappointing phase 2b trial results. The market potential of the CUD and NDD indications alone could top 2 billion euros ($2.12 billion) globally, the company noted. Lynn Durham.

Compounding 59

Compounding Drug Development 59

Digital Pharmacist

FEBRUARY 13, 2023

During this time he studied textbooks on the compounding of medicines and mastered his trade. Photo courtesy of APhA Mary Munson Runge (1928 – 2014) Mary Munson Runge was the daughter of a physician and pharmacy owner that was regarded as one of the most successful entrepreneurs in Donaldsonville, Louisiana.

Community Pharmacies 97

Community Pharmacies Hospitals Compounding 97

pharmaphorum

JULY 8, 2021

Hoos is leaving GSK after nine years, a period that saw a complete revamp of the unit including the wholesale divestment of cancer drugs to Novartis in a $16 billion deal announced in 2014 – which completed as he took over the division.

Compounding 105

Compounding 105

European Pharmaceutical Review

OCTOBER 23, 2023

In most cases, formulation compounds represent a fixed starting point from which any changes can be implemented, whereas tableting process parameters as well as machine condition, can be managed and optimised to their best, combining the knowledge of the machine manufacturer with the experience of the pharmaceutical industry.

Compounding 98

Compounding Pharmaceutical Manufacturing 98

Pharmaceutical Technology

JANUARY 23, 2023

Out of the seven biologics approved to treat moderate to severe CD in adults, only the anti-TNFαs, Remicade (infliximab), and Humira (adalimumab), have been approved for paediatric patients, with Humira receiving the most recent approval in 2014.

Compounding 59

Compounding Labelling Drug Development 59

pharmaphorum

JANUARY 23, 2023

AbbVie paid Morphic $100 million upfront to claim a share of the programme in 2018, and stumped up another $20 million to opt into specific compounds in 2020, but pulled out altogether last year. The collaboration was focused on development of alpha V beta 6 drugs for fibrotic diseases, including idiopathic pulmonary fibrosis (IPF).

Compounding 52

Compounding 52

The Thyroid Pharmacist

AUGUST 18, 2023

Benefits and Uses of Curcumin Turmeric’s medicinal benefits can mostly be attributed to compounds called curcuminoids. Combining curcumin with piperine, an alkaloid found in black pepper, extends the life of curcumin in the body, making its compounds more therapeutically effective. 2014 Jul;69:182-201 [2] Prasad S, Aggarwal BB.

Dosage 98

Dosage Compounding Labelling Diabetes 98

Pharmacy Joe

OCTOBER 25, 2023

The removal appears to be in response to the publication of a 2021 article in the International Journal of Pharmaceutical Compounding. The list was originally compiled and updated by John Mitchell, PharmD, who passed away on June 10, 2014.

Dosage 52

Dosage Inpatient Packaging Documentation 52

Eye on FDA

AUGUST 2, 2022

And since 2014 the Office of Prescription Drug Promotion (OPDP) has broken double digits only 3 times, producing only 6 letters in both 2020 an 2021. The characterization of investigative data resulted in a violation related to promotion of an unapproved compound. In 1998, there were 156 letters issued in a single year.

Communication 88

Communication Pharmaceutical Companies Pharmaceutical Companies Documentation 88

European Pharmaceutical Review

JANUARY 18, 2024

Insomnia market Dual orexin receptor antagonists (DORAs) [dual orexin receptor antagonists (DORAs)]… offer a new mechanism of action [in treating insomnia]” Across the seven major markets, the insomnia market is anticipated to grow at a compound annual growth rate (CAGR) of 2.6 percent from $3.2 billion in 2022 to $4.1

Drug Pricing 98

Drug Pricing Biosimilars Compounding 98

pharmaphorum

JANUARY 27, 2023

An additional note of optimism is that UK biotechs achieved pivotal milestones in their development, with Verona Pharma reporting a successful phase 3 trial for Ensifentrine, the first novel compound in over 10 years to address the ongoing needs of more than 380 million patients worldwide suffering from Chronic Obstructive Pulmonary Disease (COPD).

Compounding 52

Compounding Pharmaceutical Companies Pharmaceutical Companies 52

European Pharmaceutical Review

SEPTEMBER 25, 2023

NMR relaxation methods distinguish between components (phases or compounds) that have different molecular mobilities For monoclonal antibodies, identification methodologies can employ chromatography, spectroscopy, isoelectric focusing, capillary electrophoresis and peptide mapping techniques. 2014; 53(48): 7515–22. Chromatography.

Compounding 98

Compounding Pharmaceutical Companies Pharmaceutical Companies 98

RX Note

JUNE 5, 2023

Phenylketonuria Risk Aspartame is catabolized to phenylalanine among other compounds, making it unsafe for consumption in individuals with phenylketonuria. Stability at High Temperature Aspartame is unstable at high temperatures and cannot be used for baking or cooking.

Packaging 52

Packaging Compounding Diabetes 52

RX Note

APRIL 7, 2024

Wart paints containing salicylic acid or similar compounds Acts by softening and destroying the lesion by chemically burning, thus mechanically removing affected tissue. Topical salicylic acid and liquid nitrogen cryotherapy have the best evidence for efficacy. The former is less painful. Surgical removal (e.g.

Compounding 52

Compounding Immunization Immunity Community Pharmacies 52

pharmaphorum

MAY 7, 2021

For nearly 25 years, Jeremy has focused on aiding the biopharmaceutical and health sciences industry in the development of key compounds and new therapies. He has been reporting on the pharma industry since 2014 and has worked at a number of leading publications in the UK. About the interviewee. Jeremy Edwards is CEO of Xperiome.

Drug Development 126

Drug Development Compounding 126

European Pharmaceutical Review

DECEMBER 21, 2022

Organic compounds are arguably the foundation of the pharmaceutical industry. All traditional small molecule pharmaceuticals include carbon building blocks” Organic compounds are arguably the foundation of the pharmaceutical industry. Chem Commun 2014, 50, 9650‒9652. Org Process Res Dev 2022, 26, 9, 2685–2693.

Compounding 97

Compounding Pharmaceutical Manufacturing Pharmaceutical Companies Pharmaceutical Companies 97

pharmaphorum

JULY 9, 2014

The global pharmaceutical market passes a significant milestone in 2014: reaching one trillion US dollars in total value.

Compounding 52

Compounding 52

PharmD Live

MAY 13, 2024

It is estimated that approximately 90% of seniors aged 65 and older take at least one medication, 42% take five or more medications, and at least 18% are on ten or more drugs chronically. Data from the U.S. shows that the proportion of older adults taking five or more medications tripled from 13.8% in 1994 to 42.4%

Long-Term Care Facilities 105

Long-Term Care Facilities Diabetes Nursing Homes Prescription Filling 105

pharmaphorum

JANUARY 8, 2021

According to the figures compiled in the third quarter of last year, pharma brands were projected to spend around $10 billion in 2020 on digital advertising aimed at all groups including doctors, a compound annual growth rate of more than 13% since 2014.

Communication 84

Communication Compounding 84

European Pharmaceutical Review

JULY 5, 2022

Introducing an irinotecan tablet formulation, in combination with other effective oral compounds, provides the opportunity for patients to receive an all-oral, metronomic chemotherapy with better efficacy in a more convenient and cost-effective regimen. accessdata.fda.gov/drugsatfda_docs/label/2014/020571s048lbl.pdf [Accessed 25.01.22].

Chemotherapy 104

Chemotherapy Dosage Labelling Compounding 104

Quality Matters

MARCH 1, 2024

USP has a long-standing history of healthcare standards including those for compounding preparations that are tailored to meet the unique needs of patients who may not otherwise have access to their medications. Washington (DC): 2014; pharmacogenomics working group whose mission is to develop a 56. Nature 520, 609–611 (2015).

Labelling 52

Labelling Compounding 52

pharmaphorum

FEBRUARY 18, 2021

Eli Lilly’s Humalog compound and formulation patents expired in 2013 and 2014, respectively. The history of insulin captures one of the mystifying complexities of the pharmaceutical market — how long-standing drugs become more expensive with time and competition fails to hold down prices.

Prescription Filling 52

Prescription Filling Drug Pricing Biosimilars Compounding 52

European Pharmaceutical Review

FEBRUARY 28, 2023

Pathways for N-Nitroso Compound Formation: Secondary Amines and Beyond. 1,2 Of the limited number of N -nitrosamines in the Lhasa Cancer Potency Database (LCPD), less than four percent are NDSRIs. EMA/409815/2020 Rev.13. López-Rodríguez R, McManus JA, Murphy NS, et al. Org Proc Res Dev. 2020; 24(9): 1558–1585. Cross KP, Ponting DJ.

Compounding 98

Compounding 98

pharmaphorum

JANUARY 18, 2021

This has been compounded with the looming spectre of Brexit, which has meant the NHS lost some of its valuable workforce from overseas. Karina founded Acumentice in 2014, with a view to share this expertise through the development of clear and sustainable methodologies and frameworks.

Compounding 79

Compounding Hospitals 79

European Pharmaceutical Review

JULY 4, 2024

The intricate nature of botanical products further compounds the challenge, demanding a paradigm shift in regulatory interpretation and QC standards. In the UK, the dichotomy between traditional herbal registration and MA delineates the regulatory framework for herbal medicines, catering to both minor and major health conditions.

Drug Development 103

Drug Development Biosimilars Documentation Labelling 103

The Pharmacist Blog

MARCH 28, 2015

compound interest with higher debt working against the pharmacist not accounted for). missed opportunity for compound interest). missed opportunity for free money and compound interest). Key take aways: save early, invest early, compound interest is your friend, minimize debt, live smart, and avoid being sucked into consumerism.

Pharmacy Technician 52

Pharmacy Technician Hospitals Compounding Inpatient 52

pharmaphorum

DECEMBER 2, 2020

It was at this time they set their site at Sandwich in the UK, initially just to finish processing compounds imported from America, but due to tariffs on imported products the company rapidly expanded the plant to accommodate producing medicines from scratch. Likewise, tanezumab, an anti-osteoarthritic, failed in trials.

Compounding 128

Compounding Vaccines Biosimilars Diabetes 128

European Pharmaceutical Review

JANUARY 29, 2024

22,23 Dissolution In EPR Issue 4 2023 the “key role that dissolution testing has in the quality control of pharmaceutical drug products, its relevance for poorly soluble compounds, and how its limitations can impact determination of bioavailability” 24 was examined. 21 Similar strategies were applied by FDA and other regulatory agencies.

Drug Development 111

Drug Development Vaccines Compounding 111

European Pharmaceutical Review

JULY 13, 2023

While this is essential in the interrogation of novel compounds for which we know very little about their efficacy and safety, it is also true that some biomedical research is highly wasteful. 3 Moreover, some studies have suggested that co-administration of these compounds can modulate the effects of one another at a receptor level.

Compounding 98

Compounding Drug Development Clinical Pharmacology Documentation 98

The Thyroid Pharmacist

FEBRUARY 17, 2023

A study in 2014 investigated NAC’s effectiveness in preventing the formation of biofilms, as well as in the destruction of existing ones. NAC’s sulfurous compounds can often cause a “rotten-egg” smell — but that is normal! 2014 Oct;18(19):2942-8. [20] Amino Acids. 2017;49(12):1915-1929. A systematic review. 2017;19(1):11-17.

Diabetes 98

Diabetes Immunity Immunization Dosage 98

The Thyroid Pharmacist

NOVEMBER 15, 2024

Compounding pharmacies will sometimes repackage these drugs, or create lower or different concentrations than what’s typically available. Berberine Berberine is a natural compound found in several plants, including goldenseal and barberry. Supports Gut Health Berberine’s alkaloid compounds may help support a balanced gut microbiome.

Diabetes 68

Diabetes Immunization Immunity Compounding 68