The Happy PharmD

OCTOBER 28, 2024

A significant data breach in 2013 compromised the credit and debit card information of millions, shaking consumer trust. Target’s overall profit margins were low, compounded by costly operational issues and the aftermath of shutting down its Canadian operations, which resulted in a $2.5 billion loss.

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European Pharmaceutical Review

OCTOBER 19, 2023

With alpha particles, you must be very careful how the drug is made to ensure that the compound remains stable between manufacturing and use. FAP is expressed in cancer-associated fibroblasts across nearly all epithelial-derived cancers, which includes breast, pancreatic, and gastrointestinal cancers.

Chemotherapy 105

Chemotherapy Compounding Immunity Immunization 105

European Pharmaceutical Review

SEPTEMBER 25, 2023

NMR relaxation methods distinguish between components (phases or compounds) that have different molecular mobilities For monoclonal antibodies, identification methodologies can employ chromatography, spectroscopy, isoelectric focusing, capillary electrophoresis and peptide mapping techniques. 2013; 102(1): 52–61. J Pharm Sci.

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ID Stewardship

APRIL 16, 2023

This number was as high as 95% in 2013 so over the past decade we have seen close to a 20% drop in the pass rate. First time pass rates across all American College of Pharmaceutical Education (ACPE) accredited programs has dropped to 80% in 2022 with all attempt pass rates dipping to 78%. Why is this happening?

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Compounding 98

Express Pharma

NOVEMBER 1, 2024

Streamlined regulatory pathways One of the biggest enablers of drug repurposing is the regulatory framework designed to expedite approvals for already-approved compounds. For repurposed drugs, early-stage trials such as Phase 1 or 2 might be sufficient, provided there is existing safety data on the compound,” Vyas explains.

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pharmaphorum

FEBRUARY 18, 2021

Eli Lilly’s Humalog compound and formulation patents expired in 2013 and 2014, respectively. 6 The stakes were extremely high, with annual costs of insulin reaching $736 per patient in 2013, up threefold since 2002. In late 2017, the FDA approved Admelog, Sanofi’s biosimilar of Humalog.

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RX Note

APRIL 16, 2023

Introduction Vitamins are chemically unrelated families of organic compounds that are essential in small amounts for normal metabolism. Because vitamins (with the exception of vitamin D 3 , vitamin K 2 and B 12 ) cannot be synthesized by humans , they need to be ingested in the diet to prevent disorders of metabolism.

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PharmD Live

MAY 30, 2024

The side effects can compound, resulting in a greater negative impact on a patient’s health than the individual effects of one medication alone. US Emergency Department Visits for Outpatient Adverse Drug Events, 2013-2014. Adverse Drug Reactions (ADRs) Adverse drug reactions are a major concern in polypharmacy. Neurology (2015).

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Clinical Pharmacology Hospitals Long-Term Care Facilities Dosage 119

European Pharmaceutical Review

FEBRUARY 28, 2023

Pathways for N-Nitroso Compound Formation: Secondary Amines and Beyond. 2022; 35(11): 1997–2013. 1,2 Of the limited number of N -nitrosamines in the Lhasa Cancer Potency Database (LCPD), less than four percent are NDSRIs. EMA/409815/2020 Rev.13. López-Rodríguez R, McManus JA, Murphy NS, et al. Org Proc Res Dev. 2020; 24(9): 1558–1585.

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Compounding 98

Pharmaceutical Technology

OCTOBER 25, 2022

From 1990 through 2013, the FDA approved 131 FDC products, on average 5.7 Recognising that cost savings, lower risk, and accelerated timelines can be achieved by partnering with a CDMO that has a proven track record of successfully producing FDC products is an important next step. More FDC products flowing into pharma pipelines.

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Dosage Pharmaceutical Companies Pharmaceutical Companies Packaging 52

pharmaphorum

FEBRUARY 12, 2021

This may be compounded by a misconception that the field is mature, with the first discoveries having been made in the 1970s. The company was acquired by Ipsen in July 2013 where John became Head of Discovery for Ipsen Neurosciences and Site Head for the Ipsen Research facility near Oxford. It’s also extremely complex.

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Compounding 105

RX Note

AUGUST 4, 2023

Apart from Malaysian Clinical Practice Guidelines , other recommended local references include: ADR Reporters Guide Ampang Protocol, 2012 Anticoagulation MTAC Protocol, 2020 Antidote Quick Guide, 2022 Cancer Drug Counselling A Guide for Pharmacist, 2017 Clinical Pharmacokinetics Pharmacy Handbook, 2019 Code of Ethics for Pharmacists, 2018 Critical (..)

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Hospitals Inpatient Community Pharmacies Dosage 52

The Thyroid Pharmacist

NOVEMBER 4, 2022

While the human body (via the liver and kidneys) can produce up to 4 g/day of inositol, it has been found that the overly processed, high glucose (and low fiber) Western diets that many people follow, only provide about 1 g/day of the compound. (7). doi:10.1155/2013/424163. 2013 Feb;17(4):537-40. Journal of Thyroid Research.

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European Pharmaceutical Review

JANUARY 16, 2023

MALDI-TOF works on the basis of the ionisation of chemical compounds and measurements of their mass to charge (m/z) ratio. Prior to November 2013 he worked for Merck Research Laboratories in Summit, New Jersey as the Senior Principal Scientist in early phase drug development.

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Vaccines Research Laboratories Documentation Compounding 128

The Thyroid Pharmacist

OCTOBER 25, 2022

Interestingly, these foods can also contain estrogen-mimicking compounds, which can contribute to estrogen dominance. A 2018 study found that a compound called zearalenone, an estrogen-like fungi, can colonize wheat, corn, and other grains. I first reached out to Magdalena in 2013, after publishing my book Hashimoto’s: The Root Cause.

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Compounding Mayo Clinic Labelling Immunity 57

The Thyroid Pharmacist

AUGUST 18, 2023

Benefits and Uses of Curcumin Turmeric’s medicinal benefits can mostly be attributed to compounds called curcuminoids. Combining curcumin with piperine, an alkaloid found in black pepper, extends the life of curcumin in the body, making its compounds more therapeutically effective. Published 2013 Dec 6. 2013;2(4):636-652.

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The Thyroid Pharmacist

JULY 8, 2022

In one study done in 2013, patients with autoimmune thyroiditis were split into two groups, with one group being treated with 600 mg of myo-inositol and 83 mcg of selenium (selenomethionine) per day for 6 months, and the other being treated with just 83 mcg of selenium. doi:10.1155/2013/424163. doi:10.1155/2013/424163.

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The Thyroid Pharmacist

OCTOBER 28, 2022

Spore Flora contains five targeted Bacillus strains, which have the natural ability to produce a multitude of enzymes, secretory proteins (proteins secreted by cells), antimicrobial compounds, vitamins, and carotenoids (beneficial antioxidants). Published 2013 Apr 18. doi:10.1155/2013/767482. ScientificWorldJournal.

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Health and Personal Care Stores Immunization Immunity Grocery Stores 105

The Thyroid Pharmacist

JULY 1, 2022

Raw greens and wild plants such as collard greens, turnips, spinach, dandelion, arugula and mustard greens, that contain bitter compounds, can stimulate all aspects of digestion, including bile secretion, pancreatic enzyme secretion, and stomach acid secretion. (21, 2013 ; 51(5):293-296. Published 2013 Dec 6. Acta Med Iran.

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The Thyroid Pharmacist

JULY 29, 2022

I’ve seen a number of airborne toxins showing up as frequent triggers/exacerbating factors for my clients’ autoimmune conditions — mold, volatile organic compounds (VOCs), and artificial/synthetic fragrances, in particular. For cleaning products, only compounds need to be identified. Volatile Organic Compounds (VOCs) .

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Health and Personal Care Stores Compounding Immunity Immunization 52

The Thyroid Pharmacist

SEPTEMBER 20, 2024

63] Many of the benefits of ginger are due to gingerol and shogaol, compounds called gingeroids, which may also help with bloating, belching, and discomfort after meals. [64] Published December 2013. According to a 2015 research review, 100 milligrams of ginger extract may increase bowel movements. [63] Accessed June 6, 2023.

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Health and Personal Care Stores Diabetes Chemotherapy Medication Therapy Management (MTM) 64

The Thyroid Pharmacist

DECEMBER 6, 2023

22] Nightshades contain alkaloids, which are chemical compounds that can be reactive substances in some people. Published 2013 Apr 18. doi:10.1155/2013/219840 [13] Eswaran S, Muir J, Chey WD. Forty-seven percent of readers found removing nightshades relieved their joint aches, pain, swelling, tingling, and numbness.

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Pharmaceutical Technology

OCTOBER 10, 2022

Since the publication of the fifth Diagnostic and Statistical Manual of Mental Disorders in 2013, both conditions are grouped under the term FSIAD, which includes reduced arousal and interest. One Phase II trial was completed back in 2013, as per ClinicalTrials.gov. These two combinations serve different purposes.

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The Thyroid Pharmacist

SEPTEMBER 2, 2022

A 2013 study showed supplementation with myo-inositol and D-chiro-inositol led to a significant improvement in insulin sensitivity in those with PCOS. A study conducted in 2012-2013 showed a decrease in HBA1c (average blood sugar) levels in those who took 4000 IU of vitamin D daily, compared to the group that took a placebo. (53)

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Diabetes Health and Personal Care Stores Immunity Immunization 98

The Thyroid Pharmacist

OCTOBER 21, 2022

In general, the anti-bacterial compounds derived from plant sources tend to spare the healthy gut bacteria more so than pharmacological antibiotics, which may decrease the risk of diarrhea and other digestive complications. doi:10.1155/2013/606212. Asian Pac J Trop Biomed. 2013;3(7):505-514. doi:10.1016/S2221-1691(13)60105-7.

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The Thyroid Pharmacist

DECEMBER 7, 2022

A few of the most common types of flame retardants include: Halogenated compounds (containing bromine and/or chlorine and known as polychlorinated biphenyls, polybrominated diphenyl ethers, etc.). The PBDEs consisted of several commercial mixtures known as octa-BDE, penta-BDE, and deca-BDE (all phased out by 2013 in the U.S.;

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The Thyroid Pharmacist

AUGUST 19, 2022

A 2013 Chinese study found a rate of H. Thymoquinone (TQ), one of the active compounds found in black seed oil, acts as a biofilm disruptor, meaning that it can break free from the protective coating that H. Evidence-Based Complementary and Alternative Medicine 2013, Article ID 263805, 8 pages, 2013. pylori is treated. (2-7).

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Health and Personal Care Stores Immunization Immunity Dosage 98

The Thyroid Pharmacist

AUGUST 4, 2023

I first started taking methylation support in 2013, and I attribute proper methylation support to my remission from Hashimoto’s symptoms. Compound heterozygous variation – You have one normal 677 and 1298 gene, and one variation on both the 677 and 1298 genes.

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Insurance Coverage and Processing Immunization Immunity Dosage 105

Putting Patients First Blog

MARCH 27, 2024

This is due to the persistent disbelief in the words of female patients, and it can be compounded and worsened for non-white patients who must content with both sexism and racism when they are seeking care. Diagnosing women accurately appears to be a challenge in medicine that has continued for centuries.

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The Thyroid Pharmacist

NOVEMBER 29, 2024

Some report more weight loss with T4/T3 combinations (Armour*, Nature-Throid, compounded medications) versus T4 medications (Synthroid, Levoxyl, Tirosint) alone. A 2013 study explored the effects of myo-inositol and D-chiro-inositol supplementation on metabolic health in individuals with PCOS. [3] 2013 Feb;17(4):537-40. [4]

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Health and Personal Care Stores Diabetes Immunity Immunization 98

The Thyroid Pharmacist

SEPTEMBER 23, 2022

Other plants also contain this organic compound, but aloe vera contains an especially large amount, with over 12 different anthraquinones. The active compounds found in aloe vera have been found to have immune-modulating benefits. This may be due to the plant’s high amino acid content. Immune Health. Precautions.

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Immunization Immunity Compounding Diabetes 98

The Thyroid Pharmacist

NOVEMBER 3, 2023

9] When the body is exposed to an allergen, histamine production increases and turns on inflammatory processes to protect the body from that compound. A full, extended stomach may put pressure on the lower esophageal sphincter (LES), the muscle that keeps stomach acid from backing up into the esophagus, causing reflux. [8]

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Immunity Immunization Dosage Mayo Clinic 98

The Thyroid Pharmacist

FEBRUARY 1, 2023

This is because coffee lowers the intestinal absorption of both inorganic and organic compounds, and seems to physically interact with thyroid medications. [5] In addition to the varied amount of caffeine in such substances, the other compounds found in these substances tend to affect how a person reacts to the caffeine.

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The Thyroid Pharmacist

SEPTEMBER 29, 2023

A 2013 study found that H. 38] Berberine is a natural plant compound that has blood-sugar balancing properties, and also contains alkaloids that have broad-spectrum antimicrobial and antiparasitic properties, making it effective in helping to clear gut infections and overgrowths of pathogenic bacteria. [39] 2013 Nov 11;8(11):e80042.

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The Thyroid Pharmacist

OCTOBER 27, 2023

I started talking to Carter Black, RPh, my compounding pharmacist, about the symptoms I was experiencing, and he suggested that I have my adrenals tested. Garlic Oil Garlic is another natural compound that provides a host of health benefits. Published 2013 Dec 26. 2013-3950. [30] Adv Exp Med Biol. 2019;1182:1-37.

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The Thyroid Pharmacist

JANUARY 6, 2023

Around 60 percent of readers whom I surveyed, reported an improved mood after switching to a T3/T4 combo medication like Nature-Throid, WP Thyroid, Armour, or a compounded T4/T3 version. Published 2013 Nov 15. Published 2013 Nov 11. Hum Psychopharmacol. 2022;37(6):e2852. doi:10.1002/hup.2852. Syed EU, Wasay M, Awan S.

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The Thyroid Pharmacist

MAY 26, 2023

Again, having low stomach acid further compounds this by providing an environment that is not well defended against bacteria. Published 2013 May 30; Pancreatic elastase. Published 2013. The lack of thyroxine (free T4), as seen in Hashimoto’s, also decreases liver cholesterol metabolism. [14] Acta Med Iran. 2013;51(5):293-296.

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Health and Personal Care Stores Diabetes Dosage Immunization 98