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SAEM Clinical Images Series: A Dangerous Cause of Abdominal Pain

ALiEM - Pharm Pearls

The most common pathogen is Klebsiella pneumoniae, and diabetes mellitus is the most common risk factor. Consider it especially in the patient with abdominal pain with diabetes mellitus. 2012 Oct;55(7):930-9. Epub 2012 Jun 19. Additional Images Physical Exam Vitals : BP 172/71; HR 127; T 35.9°C; mg/dL Ketone body : 5.9

Diabetes 161
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SAEM Clinical Images Series: A Case of Painful Skin Lesions

ALiEM - Pharm Pearls

A 50-year-old Caucasian female with a history of hypertension, coronary artery disease, and insulin-dependent diabetes mellitus presents to the emergency department with a complaint of painful sores on the top of her left foot. It may be equally common in patients without diabetes, hence was renamed without the term “diabeticorum”.

Diabetes 161
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Towards a new understanding of cardiovascular risk in diabetes

pharmaphorum

A new post-hoc analysis from Novo Nordisk of their SUSTAIN 6 and PIONEER 6 studies into semaglutide is looking to help ‘individualise’ treatment for diabetes patients by better predicting their cardiovascular lifetime risk. The two studies included 6,480 people with type 2 diabetes with high cardiovascular risk aged between 50-90 years.

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SAEM Clinical Images Series: Penile Lesion with a Poor Prognosis

ALiEM - Pharm Pearls

Penile calciphylaxis is a rare finding that often portends a poor prognosis with a high mortality rate. References Nunley JR. Calcinosis cutis. link] Vedvyas, C., Winterfield, L. S., & Vleugels, R. Calciphylaxis: a systematic review of existing and emerging therapies. Journal of the American Academy of Dermatology, 67(6), e253–e260.

Hospitals 152
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Novo Nordisk bulks up in rare diseases with $1.2bn Prothena deal

pharmaphorum

Diabetes giant Novo Nordisk has opened a new front in its rare disease R&D, thanks to an acquisition agreement with Prothena focusing on drugs for ATTR amyloidosis. All told, the deal could be worth up to $1.2 In ATTR amyloidosis, transthyretin (TTR) protein misfolds and accumulates as amyloid deposits throughout the body.

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Why Balancing Blood Sugar is Vital for Hashimoto’s Health

The Thyroid Pharmacist

A review paper published in 2010 that discussed the relationship between thyroid dysfunction and metabolic disorders, highlighted the fact that patients with diabetes were up to three times more likely to develop a thyroid disorder. (7). Hypoglycemia is an early risk factor for developing diabetes. Type 2 Diabetes.

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NICE unlocks use of Amarin’s Vazkepa in 425k NHS patients

pharmaphorum

The drug has also been approved for primary prevention of MACE in people with diabetes and cardiovascular risk factors, but NICE said the data suggest that Vazkepa is “unlikely to be cost effective for primary prevention” so is not recommended for these patients. .”