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A major strategy for OV development is genetic manipulation to weaken virus pathogenicity, enhance target selectivity, reduce adversereactions, and/or insert exogenous therapeutic genes into the virus genome. OVs can be attenuated natural viruses or recombinant viruses.
A new test is being developed for MAP detection in support of a vaccine for Crohn’s disease; it has been in clinical trials, and looks very promising. Testing The GI-MAP test provides Secretory IgA (SIgA) levels with a normal range between 510 to 2010 ug/g. This can often be due to mold (or other environmental toxins) in the new home.
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