Remove 2001 Remove Chemotherapy Remove Dosage
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PROTAC development gains momentum, but clinical performance is poor

Pharmaceutical Technology

The first concept for a PROTAC was published in 2001, and recently these protein degraders have gained rapid momentum as a promising novel modality. This makes early R&D less risky, as many lead compounds are discontinued due to inadequate pharmacokinetic profiles and require excessively high dosages to be pharmaceutically active.

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How Myo-inositol Can Improve Hashimoto’s Symptoms

The Thyroid Pharmacist

For example, having people take therapeutic dosages of two nutrients, selenium and myo-inositol , in addition to working to balance their blood sugar, can work wonders at reducing their anxiety and OCD symptoms, as well as reducing their thyroid antibodies and thyroid symptoms. Recommended dosage and precautions. Endokrynol Pol.

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Solutions for Constipation Relief

The Thyroid Pharmacist

Chemotherapy agents: Chemotherapy agents can lead to constipation in a variety of ways such as slowing the movements of the intestinal tract or creating inflammation that disrupts digestive function. Be sure to work with your doctor or practitioner to determine the right supplements and dosages for you. Published January 2001.

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How Does Carnitine Support Hashimoto’s?

The Thyroid Pharmacist

In one 6-month study published in 2001, fifty women were given a fixed dose of TSH-suppressive L-T(4) therapy. My experience, as well as current research, mirrors findings relayed in the 2001 Basel Thyroid Study. (37) 2001 Aug;86(8):3579-94. Role of carnitine in cancer chemotherapy-induced multiple organ toxicity.